PDB ID 5CVO     CHAIN A
Protein name WD repeat-containing protein 48
Uniprot Accession Q8TAF3
The number of similar proteins 12
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
5CVO (CHAIN: A)
1 P62068   P0CG47  
2 Monomeric state
3 O75317  
4 O94782  
5 Q8TBZ3   P62068  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   MAAHHRQNTA   GRRKVQVSYV   IRDEVEKYNR   NGVNALQLDP   ALNRLFTAGR   50
51   DSIIRIWSVN   QHKQDPYIAS   MEHHTDWVND   IVLCCNGKTL   ISASSDTTVK   100
101   VWNAHKGFCM   STLRTHKDYV   KALAYAKDKE   LVASAGLDRQ   IFLWDVNTLT   150
151   ALTASNNTVT   TSSLSGNKDS   IYSLAMNQLG   TIIVSGSTEK   VLRVWDPRTC   200
201   AKLMKLKGHT   DNVKALLLNR   DGTQCLSGSS   DGTIRLWSLG   QQRCIATYRV   250
251   HDEGVWALQV   NDAFTHVYSG   GRDRKIYCTD   LRNPDIRVLI   CEEKAPVLKM   300
301   ELDRSADPPP   AIWVATTKST   VNKWTLKGIH   NFRASGDYDN   DCTNPITPLC   350
351   TQPDQVIKGG   ASIIQCHILN   DKRHILTKDT   NNNVAYWDVL   KACKVEDLGK   400
401   VDFEDEIKKR   FKMVYVPNWF   SVDLKTGMLT   ITLDESDCFA   AWVSAKDAGF   450
451   SSPDGSDPKL   NLGGLLLQAL   LEYWPRTHVN   PMDEEENEVN   HVNGEQENRV   500
501   QKGNGYFQVP   PHTPVIFGEA   GGRTLFRLLC   RDSGGETESM   LLNETVPQWV   550
551   IDITVDKNMP   KF         600

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
19_TYR CYS 8.3kJPN
chr3:39104548
rs771625308
- 0.0001 0.6143 -
29_ASN THR 8.3kJPN
chr3:39104578
-
- 0.0001 0.8604 -
80_ASP ASN 8.3kJPN
chr3:39107350
rs544855511
- 0.0001 0.9027 -
92_SER PRO 8.3kJPN
chr3:39108044
rs1197256810
- 0.0001 0.9998 -
94_SER ALA gnomAD
chr3:39108050
rs148407227
- 0.00305306 0.9014 -
128_ASP ASN 8.3kJPN
chr3:39108267
-
- 0.0001 0.5221 -
159_VAL ALA 8.3kJPN
chr3:39108361
-
- 0.0001 0.9991 -
173_SER ILE 8.3kJPN
chr3:39110298
rs777746881
- 0.0001 0.9955 -
301_GLU ASP 8.3kJPN
chr3:39118635
-
- 0.0001 0.5231 -
309_PRO LEU 8.3kJPN
chr3:39118658
rs770868944
- 0.0002 0.0995 -
311_ALA VAL 8.3kJPN
chr3:39118664
rs1451464199
- 0.0001 0.1615 -
347_THR SER 8.3kJPN
chr3:39119694
-
- 0.0001 0.0741 -
374_HIS PRO 8.3kJPN
chr3:39121247
-
- 0.0001 0.9936 -
535_GLY SER 8.3kJPN
chr3:39130744
-
- 0.0001 0.5432 -
540_MET VAL 8.3kJPN
chr3:39130759
rs753370972
- 0.0001 0.1287 -
543_ASN HIS 8.3kJPN
chr3:39130768
-
- 0.0002 0.2085 -
561_LYS ARG gnomAD
chr3:39133129
rs139870313
- 0.00105435 0.1416 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.