PDB ID 4YFD     CHAIN A
Protein name Receptor-type tyrosine-protein phosphatase delta
Uniprot Accession Q64487
The number of similar proteins 7
The number of binding states 5
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
4YFD (CHAIN: A)
1 Q61730  
2 Q64487  
3 Q810C0  
4 Q96NI6  
5 Q8BYM5  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   ETPPRFTRTP   VDQTGVSGGV   ASFICQATGD   PRPKIVWNKK   GKKVSNQRFE   50
51   VIEFDDGSGS   VLRIQPLRTP   RDEAIYECVA   SNNVGEISVS   TRLTVLREDQ   100
101   IPRGFPTIDM   GPQLKVVERT   RTATMLCAAS   GNPDPEITWF   KDFLPVDTSN   150
151   NNGRIKQLRS   ESIGGTPIRG   ALQIEQSEES   DQGKYECVAT   NSAGTRYSAP   200
201   ANLYVRELRE   VRRVPPRFSI   PPTNHEIMPG   GSVNITCVAV   GSPMPYVKWM   250
251   LGAEDLTPED   DMPIGRNVLE   LNDVRQSANY   TCVAMSTLGV   IEAIAQITVK   300
301   ALPKPPGTPV   VTESTATSIT   LTWDSGNPEP   VSYYIIQHKP   KNSEEPYKEI   350
351   DGIATTRYSV   AGLSPYSDYE   FRVVAVNNIG   RGPASEPVLT   QTSEQAPSSA   400
401   PRDVQARMLS   STTILVQWKE   PEEPNGQIQG   YRVYYTMDPT   QHVNNWMKHN   450
451   VADSQITTIG   NLVPQKTYSV   KVLAFTSIGD   GPLSSDIQVI   T   500

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
38_VAL ILE gnomAD
chr9:8636818 		rs146973770
- 0.000278503 -
39_ASP ASN 8.3kJPN
chr9:8636815 		-
- 0.0001 -
44_SER PRO 8.3kJPN
chr9:8636800 		-
- 0.0001 -
96_THR ILE 8.3kJPN
chr9:8633403 		rs1208308933
- 0.0001 -
196_ARG LYS 8.3kJPN
chr9:8526629 		-
- 0.0001 -
227_PRO SER gnomAD
chr9:8524946 		rs567730036
- 0.000398632 -
239_ARG CYS 8.3kJPN
chr9:8521544 		-
- 0.0001 -
249_PRO LEU gnomAD
chr9:8521513 		rs139719908
- 0.000171676 -
260_VAL ILE 8.3kJPN
chr9:8521481 		rs760428875
- 0.0001 -
280_ALA VAL 8.3kJPN
chr9:8521420 		rs746204840
- 0.0001 -
283_LEU VAL 8.3kJPN
chr9:8521412 		-
- 0.0001 -
310_VAL ALA 8.3kJPN
chr9:8521330 		rs188344530
- 0.0001 -
365_HIS TYR 8.3kJPN
chr9:8518319 		rs762218066
- 0.0001 -
446_LYS ARG 8.3kJPN
chr9:8518075 		-
- 0.0001 -
454_GLN GLU gnomAD
chr9:8518052 		rs10977171
- 0.0455171 -
454_GLN GLU 8.3kJPN
chr9:8518052 		rs10977171
- 0.1067 -
471_ASN LYS 8.3kJPN
chr9:8517999 		-
- 0.0001 -
479_ALA THR 8.3kJPN
chr9:8517977 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.