PiSITE

PDB ID	4UM8	CHAIN	A
Protein name	INTEGRIN ALPHA-V
Uniprot Accession	P06756
The number of similar proteins	13
The number of binding states	4
The number of binding partners	5

Binding state	Binding partners
	4UM8 (CHAIN: A)
1	P18564
2	P06756 P26012
3	P18564 9CZA 9CZA
4	P18564 P01137 P01137

Molecule viewer

Only interaction residues

#binding
partners

	3
	2
	1
	0

Sequence information

1

FNLDVDSPAE

YSGPEGSYFG

FAVDFFVPSA

SSRMFLLVGA

PKANTTQPGI

50

51

VEGGQVLKCD

WSSTRRCQPI

EFDATGNRDY

AKDDPLEFKS

HQWFGASVRS

100

101

KQDKILACAP

LYHWRTEMKQ

EREPVGTCFL

QDGTKTVEYA

PCRSQDIDAD

150

151

GQGFCQGGFS

IDFTKADRVL

LGGPGSFYWQ

GQLISDQVAE

IVSKYDPNVY

200

201

SIKYNNQLAT

RTAQAIFDDS

YLGYSVAVGD

FNGDGIDDFV

SGVPRAARTL

250

251

GMVYIYDGKN

MSSLYNFTGE

QMAAYFGFSV

AATDINGDDY

ADVFIGAPLF

300

301

MDRGSDGKLQ

EVGQVSVSLQ

RASGDFQTTK

LNGFEVFARF

GSAIAPLGDL

350

351

DQDGFNDIAI

AAPYGGEDKK

GIVYIFNGRS

TGLNAVPSQI

LEGQWAARSC

400

401

PPSFGYSMKG

ATDIDKNGYP

DLIVGAFGVD

RAILYRARPV

ITVNAGLEVY

450

451

PSILNQDNKT

CSLPGTALKV

SCFNVRFCLK

ADGKGVLPRK

LNFQVELLLD

500

501

KLKQKGAIRR

ALFLYSRSPS

HSKNMTISRG

GLMQCEELIA

YLRDESEFRD

550

551

KLTPITIFME

YRLDYRTAAD

TTGLQPILNQ

FTPANISRQA

HILLDTGGLE

600

601

VLFQGPGENA

QLEKELQALE

KENAQLEWEL

QALEKELAQT

TGWRGGHVVE

650

651

GLAGELEQLR

ARLEHHPQGQ

REPAGHHHHH

H

700

Binding partner information

P18564

INTEGRIN BETA-6

Binding partner information

	P06756	Integrin alpha-V
	P26012	Integrin beta-8

Binding partner information

	P18564	Integrin beta-6
	9CZA	17E6 Fab heavy chain
	9CZA	17E6 Fab light chain

Binding partner information

	P18564	Integrin beta-6
	P01137	Transforming growth factor beta-1
	P01137	Transforming growth factor beta-1

Variants

Residue	AA	Source / dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	AlphaMissense pathogenicity	Disease name
14_PRO	ARG	8.3kJPN chr2:187455196 rs748486456	-	0.0002	0.1346	-
26_PHE	LEU	gnomAD chr2:187455233 rs201076250	-	0.000193425	0.9138	-
44_ASN	THR	8.3kJPN chr2:187466783 -	-	0.0001	0.5411	-
58_LYS	ARG	8.3kJPN chr2:187466825 rs754337745	-	0.0001	0.0812	-
60_ASP	ALA	8.3kJPN chr2:187466831 -	-	0.0001	0.1678	-
64_THR	PRO	gnomAD chr2:187466842 rs750649139	-	0.00326009	0.048	-
66_ARG	GLN	gnomAD chr2:187466849 rs201909609	-	0.000124443	0.0664	-
66_ARG	TRP	8.3kJPN chr2:187466848 rs200516634	-	0.0001	0.136	-
66_ARG	GLN	8.3kJPN chr2:187466849 rs201909609	-	0.0004	0.0664	-
77_ASN	ASP	8.3kJPN chr2:187487068 rs1168435795	-	0.0001	0.0814	-
79_ASP	GLU	gnomAD chr2:187487076 rs200368244	-	0.000123465	0.1683	-
108_CYS	TYR	8.3kJPN chr2:187490204 -	-	0.0001	0.9996	-
113_HIS	ARG	8.3kJPN chr2:187490219 rs1336656683	-	0.0001	0.5841	-
114_TRP	CYS	ClinVar chr2:187490223 rs1357935457	Pathogenic	-	-	ITGAV deficiency\|Immune dysregulation, neurodevelopmental defects, and colitis [\|MONDO:MONDO:0980702,MedGen:CN380017,OMIM:621375]
192_VAL	ILE	8.3kJPN chr2:187500841 rs200647242	-	0.0004	0.0612	-
211_ARG	GLN	gnomAD chr2:187500899 rs376680231	-	0.000108022	0.1084	-
211_ARG	TRP	8.3kJPN chr2:187500898 rs372449821	-	0.0001	0.2997	-
231_PHE	ILE	8.3kJPN chr2:187501815 -	-	0.0001	0.7417	-
232_ASN	SER	gnomAD chr2:187501819 rs184114187	-	0.000159086	0.0713	-
250_LEU	SER	8.3kJPN chr2:187503040 -	-	0.0001	0.537	-
255_ILE	MET	8.3kJPN chr2:187503144 -	-	0.0001	0.3268	-
328_THR	MET	8.3kJPN chr2:187506229 rs375790223	-	0.0001	0.0788	-
349_ASP	VAL	ClinVar chr2:187506292 rs1443125036	Pathogenic	-	-	ITGAV deficiency\|Immune dysregulation, neurodevelopmental defects, and colitis [\|MONDO:MONDO:0980702,MedGen:CN380017,OMIM:621375]
359_ALA	VAL	gnomAD chr2:187511419 rs145167954	-	0.000178155	0.6616	-
373_VAL	ILE	gnomAD chr2:187511460 rs569411702	-	0.000196765	0.0788	-
375_ILE	VAL	VAR_024289 rs3738918	LB/B	-	0.137	-
375_ILE	VAL	gnomAD chr2:187511466 rs3738918	-	0.0248177	0.137	-
375_ILE	VAL	8.3kJPN chr2:187511466 rs3738918	-	0.0594	0.137	-
408_MET	VAL	8.3kJPN chr2:187511565 -	-	0.0004	0.1091	-
414_ILE	THR	8.3kJPN chr2:187511584 rs757308379	-	0.0001	0.3841	-
414_ILE	MET	8.3kJPN chr2:187511585 -	-	0.0001	0.1929	-
423_ILE	THR	8.3kJPN chr2:187514573 -	-	0.0001	0.6515	-
431_ARG	LEU	gnomAD chr2:187514597 rs750343053	-	0.000569832	0.3663	-
441_ILE	THR	8.3kJPN chr2:187516723 rs201241523	-	0.0002	0.9287	-
444_ASN	SER	8.3kJPN chr2:187516732 rs755750941	-	0.0002	0.0725	-
452_SER	GLY	8.3kJPN chr2:187516755 -	-	0.0004	0.0912	-
453_ILE	ASN	8.3kJPN chr2:187516759 -	-	0.0001	0.6816	-
458_ASN	SER	gnomAD chr2:187516774 rs200705825	-	0.000115445	0.0829	-
465_GLY	ALA	gnomAD chr2:187516795 rs147403786	-	0.000657533	0.1547	-
465_GLY	TER	8.3kJPN chr2:187516794 -	-	0.0001	-	-
518_SER	ALA	VAR_055970 rs2230615	LB/B	-	0.1033	-
518_SER	ALA	gnomAD chr2:187521051 rs2230615	-	0.000203823	0.1033	-
520_SER	GLY	8.3kJPN chr2:187521057 rs200088164	-	0.0001	0.0841	-
522_SER	PHE	gnomAD chr2:187521064 rs146565475	-	0.000100032	0.1442	-
531_GLY	VAL	8.3kJPN chr2:187521091 rs185792013	-	0.0001	0.1843	-
540_ALA	VAL	gnomAD chr2:187521118 rs199670325	-	0.000190019	0.3764	-
548_PHE	LEU	8.3kJPN chr2:187523779 -	-	0.0001	0.9969	-
577_ILE	VAL	8.3kJPN chr2:187523864 -	-	0.0001	0.1019	-
582_THR	MET	gnomAD chr2:187523880 rs150474737	-	0.000137055	0.106	-

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Sequence information

Binding partner information

Binding partner information

Binding partner information

Binding partner information

Variants

Reference