| PDB ID | 4PLM
|
CHAIN | A |
|---|---|---|---|
| Protein name | Netrin-1 | ||
| Uniprot Accession | Q90922 | ||
| The number of similar proteins | 11 | ||
| The number of binding states | 6 | ||
| The number of binding partners | 4 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 4PLM (CHAIN: A) | |
| 1 | Monomeric state |
| 2 |
Q90922
|
| 3 |
P70211
|
| 4 |
P43146
|
| 5 |
Q7TQG5
Q6NW40
|
| 6 |
Q90922
P97798
P97798
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 41_ASP | ASN |
8.3kJPN chr17:8925805 - |
- | 0.0001 | - | - | |
| 63_GLY | ALA |
8.3kJPN chr17:8925872 - |
- | 0.0001 | - | - | |
| 75_PRO | LEU |
8.3kJPN chr17:8925908 rs1370917223 |
- | 0.0002 | - | - | |
| 101_PRO | SER |
8.3kJPN chr17:8925985 rs1438744633 |
- | 0.0001 | - | - | |
| 126_ASN | THR |
8.3kJPN chr17:8926061 rs200187924 |
- | 0.0002 | - | - | |
| 130_PHE | LEU |
gnomAD chr17:8926074 rs571334142 |
- | 0.000171276 | - | - | |
| 132_HIS | ARG |
8.3kJPN chr17:8926079 rs1262845727 |
- | 0.0002 | - | - | |
| 185_LYS | ARG |
8.3kJPN chr17:8926238 - |
- | 0.0001 | - | - | |
| 188_ASN | SER |
8.3kJPN chr17:8926247 rs751410364 |
- | 0.0001 | - | - | |
| 206_THR | SER |
gnomAD chr17:8926301 rs201736911 |
- | 0.000348586 | - | - | |
| 212_MET | VAL |
gnomAD chr17:8926318 rs199674301 |
- | 0.000397357 | - | - | |
| 213_ARG | SER |
gnomAD chr17:8926321 rs34079256 |
- | 0.000202272 | - | - | |
| 244_VAL | ALA |
8.3kJPN chr17:8926415 - |
- | 0.0004 | - | - | |
| 264_GLU | ALA |
8.3kJPN chr17:8926475 rs751977350 |
- | 0.0015 | - | - | |
| 274_TYR | CYS |
8.3kJPN chr17:8926505 - |
- | 0.0001 | - | - | |
| 298_ARG | GLY |
8.3kJPN chr17:8926576 - |
- | 0.0001 | - | - | |
| 298_ARG | HIS |
8.3kJPN chr17:8926577 rs748734505 |
- | 0.0002 | - | - | |
| 307_ASP | ASN |
8.3kJPN chr17:8926603 rs868254012 |
- | 0.0002 | - | - | |
| 348_HIS | ARG |
8.3kJPN chr17:9066148 - |
- | 0.0001 | - | - | |
| 350_ARG | TRP |
8.3kJPN chr17:9066153 rs375204917 |
- | 0.0001 | - | - | |
| 364_ARG | HIS |
8.3kJPN chr17:9066196 rs558564980 |
- | 0.0001 | - | - | |
| 374_ARG | HIS |
8.3kJPN chr17:9066226 rs1331242639 |
- | 0.0001 | - | - | |
| 377_THR | PRO |
gnomAD chr17:9066234 rs765779295 |
- | 0.00141255 | - | - | |
| 402_ALA | THR |
8.3kJPN chr17:9066309 rs1257370869 |
- | 0.0001 | - | - | |
| 447_ARG | HIS |
8.3kJPN chr17:9083250 - |
- | 0.0001 | - | - |