PDB ID 4PLM     CHAIN A
Protein name Netrin-1
Uniprot Accession Q90922
The number of similar proteins 11
The number of binding states 6
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
4PLM (CHAIN: A)
1 Monomeric state
2 Q90922  
3 P70211  
4 P43146  
5 Q7TQG5   Q6NW40  
6 Q90922   P97798   P97798  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   GYPGLNMFAV   QTAQPDPCYD   EHGLPRRCIP   DFVNSAFGKE   VKVSSTCGKP   50
51   PSRYCVVTEK   GEEQVRSCHL   CNASDPKRAH   PPSFLTDLNN   PHNLTCWQSD   100
101   SYVQYPHNVT   LTLSLGKKFE   VTYVSLQFCS   PRPESMAIYK   SMDYGKTWVP   150
151   FQFYSTQCRK   MYNKPSRAAI   TKQNEQEAIC   TDSHTDVRPL   SGGLIAFSTL   200
201   DGRPTAHDFD   NSPVLQDWVT   ATDIKVTFSR   LHTFGDENED   DSELARDSYF   250
251   YAVSDLQVGG   RCKCNGHASR   CVRDRDDNLV   CDCKHNTAGP   ECDRCKPFHY   300
301   DRPWQRATAR   EANECVACNC   NLHARRCRFN   MELYKLSGRK   SGGVCLNCRH   350
351   NTAGRHCHYC   KEGFYRDLSK   PISHRKACKE   CDCHPVGAAG   QTCNQTTGQC   400
401   PCKDGVTGIT   CNRCAKGYQQ   SRSPIAPCIK   IP     450

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
41_ASP ASN 8.3kJPN
chr17:8925805 		-
- 0.0001 -
63_GLY ALA 8.3kJPN
chr17:8925872 		-
- 0.0001 -
75_PRO LEU 8.3kJPN
chr17:8925908 		rs1370917223
- 0.0002 -
101_PRO SER 8.3kJPN
chr17:8925985 		rs1438744633
- 0.0001 -
126_ASN THR 8.3kJPN
chr17:8926061 		rs200187924
- 0.0002 -
130_PHE LEU gnomAD
chr17:8926074 		rs571334142
- 0.000171276 -
132_HIS ARG 8.3kJPN
chr17:8926079 		rs1262845727
- 0.0002 -
185_LYS ARG 8.3kJPN
chr17:8926238 		-
- 0.0001 -
188_ASN SER 8.3kJPN
chr17:8926247 		rs751410364
- 0.0001 -
206_THR SER gnomAD
chr17:8926301 		rs201736911
- 0.000348586 -
212_MET VAL gnomAD
chr17:8926318 		rs199674301
- 0.000397357 -
213_ARG SER gnomAD
chr17:8926321 		rs34079256
- 0.000202272 -
244_VAL ALA 8.3kJPN
chr17:8926415 		-
- 0.0004 -
264_GLU ALA 8.3kJPN
chr17:8926475 		rs751977350
- 0.0015 -
274_TYR CYS 8.3kJPN
chr17:8926505 		-
- 0.0001 -
298_ARG GLY 8.3kJPN
chr17:8926576 		-
- 0.0001 -
298_ARG HIS 8.3kJPN
chr17:8926577 		rs748734505
- 0.0002 -
307_ASP ASN 8.3kJPN
chr17:8926603 		rs868254012
- 0.0002 -
348_HIS ARG 8.3kJPN
chr17:9066148 		-
- 0.0001 -
350_ARG TRP 8.3kJPN
chr17:9066153 		rs375204917
- 0.0001 -
364_ARG HIS 8.3kJPN
chr17:9066196 		rs558564980
- 0.0001 -
374_ARG HIS 8.3kJPN
chr17:9066226 		rs1331242639
- 0.0001 -
377_THR PRO gnomAD
chr17:9066234 		rs765779295
- 0.00141255 -
402_ALA THR 8.3kJPN
chr17:9066309 		rs1257370869
- 0.0001 -
447_ARG HIS 8.3kJPN
chr17:9083250 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.