PDB ID 4OY9     CHAIN A
Protein name Cadherin-3
Uniprot Accession P22223
The number of similar proteins 26
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
4OY9 (CHAIN: A)
1 Monomeric state
2 P22223  
3 P22223   5JYM  
4 6ZTR   6ZTR  

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Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   DWVVAPISVP   ENGKGPFPQR   LNQLKSNKDR   DTKIFYSITG   PGADSPPEGV   50
51   FAVEKETGWL   LLNKPLDREE   IAKYELFGHA   VSENGASVED   PMNISIIVTD   100
101   QNDHKPKFTQ   DTFRGSVLEG   VLPGTSVMQV   TATDEDDAIY   TYNGVVAYSI   150
151   HSQEPKDPHD   LMFTIHRSTG   TISVISSGLD   REKVPEYTLT   IQATDMDGDG   200
201   STTTAVAVVE   ILD         250

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
3_VAL ALA 8.3kJPN
chr16:68712119 		-
- 0.0001 -
28_LYS ARG 8.3kJPN
chr16:68712417 		-
- 0.0001 -
30_ARG LYS gnomAD
chr16:68712423 		rs200737028
- 0.000147654 -
46_PRO SER 8.3kJPN
chr16:68712470 		rs779790678
- 0.0001 -
53_VAL ILE 8.3kJPN
chr16:68712491 		rs761132411
- 0.0002 -
68_ARG GLN 8.3kJPN
chr16:68712537 		-
- 0.0001 -
75_GLU ASP 8.3kJPN
chr16:68712559 		-
- 0.0001 -
98_VAL MET ClinVar
chr16:68712731 		-
Likely pathogenic - not provided [MedGen:C3661900]
112_THR SER 8.3kJPN
chr16:68712774 		rs768894285
- 0.0001 -
114_ARG TER ClinVar
chr16:68712779 		rs761941770
Pathogenic - not provided|Congenital hypotrichosis with juvenile macular dystrophy [MedGen:C3661900|MONDO:MONDO:0011107,MedGen:C1832162,OMIM:601553,Orphanet:1573]
130_VAL MET VAR_031929 rs17854171
LB/B - -
142_TYR TER ClinVar
chr16:68713757 		rs1597807758
Pathogenic - Hypotrichosis with juvenile macular dystrophy|not provided [|MedGen:C3661900]
162_MET LEU gnomAD
chr16:68713815 		rs36038900
- 0.00410377 -
170_GLY ASP ClinVar
chr16:68713840 		rs1597807897
Likely pathogenic - Hypotrichosis with juvenile macular dystrophy [-]
189_LEU VAL gnomAD
chr16:68714889 		rs565345878
- 0.000202807 -
192_GLN TER ClinVar
chr16:68714898 		rs866290802
Pathogenic - not provided [MedGen:CN517202]
196_MET ILE gnomAD
chr16:68714912 		rs148535251
- 0.00106989 -
204_THR MET 8.3kJPN
chr16:68714935 		rs527796702
- 0.0001 -
211_ILE VAL 8.3kJPN
chr16:68714955 		rs1222076087
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.