PDB ID 4NNJ     CHAIN A
Protein name Ubiquitin-activating enzyme E1 1
Uniprot Accession P22515
The number of similar proteins 14
The number of binding states 8
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
4NNJ (CHAIN: A)
1 P22515   P0CG63  
2 Monomeric state
3 P14682  
4 P05759  
5 P52490  
6 P52490   P52490  
7 P69326   P14682  
8 P22515   P0CG63   P0CG63  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   MGSSHHHHHH   SSGENLYFQG   SHMASAAGEI   DESLYSRQLY   VLGKEAMLKM   50
51   QTSNVLILGL   KGLGVEIAKN   VVLAGVKSMT   VFDPEPVQLA   DLSTQFFLTE   100
101   KDIGQKRGDV   TRAKLAELNA   YVPVNVLDSL   DDVTQLSQFQ   VVVATDTVSL   150
151   EDKVKINEFC   HSSGIRFISS   ETRGLFGNTF   VDLGDEFTVL   DPTGEEPRTG   200
201   MVSDIEPDGT   VTMLDDNRHG   LEDGNFVRFS   EVEGLDKLND   GTLFKVEVLG   250
251   PFAFRIGSVK   EYGEYKKGGI   FTEVKVPRKI   SFKSLKQQLS   NPEFVFSDFA   300
301   KFDRAAQLHL   GFQALHQFAV   RHNGELPRTM   NDEDANELIK   LVTDLSVQQP   350
351   EVLGEGVDVN   EDLIKELSYQ   ARGDIPGVVA   FFGGLVAQEV   LKACSGKFTP   400
401   LKQFMYFDSL   ESLPDPKNFP   RNEKTTQPVN   SRYDNQIAVF   GLDFQKKIAN   450
451   SKVFLVGSGA   IGCEMLKNWA   LLGLGSGSDG   YIVVTDNDSI   EKSNLNRQFL   500
501   FRPKDVGKNK   SEVAAEAVCA   MNPDLKGKIN   AKIDKVGPET   EEIFNDSFWE   550
551   SLDFVTNALD   NVDARTYVDR   RCVFYRKPLL   ESGTLGTKGN   TQVIIPRLTE   600
601   SYSSSRDPPE   KSIPLCTLRS   FPNKIDHTIA   WAKSLFQGYF   TDSAENVNMY   650
651   LTQPNFVEQT   LKQSGDVKGV   LESISDSLSS   KPHNFEDCIK   WARLEFEKKF   700
701   NHDIKQLLFN   FPKDAKTSNG   EPFWSGAKRA   PTPLEFDIYN   NDHFHFVVAG   750
751   ASLRAYNYGI   KSDDSNSKPN   VDEYKSVIDH   MIIPEFTPNA   NLKIQVNDDD   800
801   PDPNANAANG   SDEIDQLVSS   LPDPSTLAGF   KLEPVDFEKD   DDTNHHIEFI   850
851   TACSNCRAQN   YFIETADRQK   TKFIAGRIIP   AIATTTSLVT   GLVNLELYKL   900
901   IDNKTDIEQY   KNGFVNLALP   FFGFSEPIAS   PKGEYNNKKY   DKIWDRFDIK   950
951   GDIKLSDLIE   HFEKDEGLEI   TMLSYGVSLL   YASFFPPKKL   KERLNLPITQ   1000
1001   LVKLVTKKDI   PAHVSTMILE   ICADDKEGED   VEVPFITIHL     1050

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.