PDB ID 4N7V     CHAIN A
Protein name Serine/threonine-protein kinase PLK4
Uniprot Accession O00444
The number of similar proteins 12
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
4N7V (CHAIN: A)
1 O00444   O94986  
2 K7ELX0  
3 O00444  
4 Q5VWP2  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   WGYQNRTLRS   ITSPLVAHRL   KPIRQKTKKA   VVSILDSEEV   CVELVKEYAS   50
51   QEYVKEVLQI   SSDGNTITIY   YPNGGRGFPL   ADRPPSPTDN   ISRYSFDNLP   100
101   EKYWRKYQYA   SRFVQLVRSK   SPKITYFTRY   AKCILMENSP   GADFEVWFYD   150
151   GVKIHKTEDF   IQVIEKTGKS   YTLKSESEVN   SLKEEIKMYM   DHANEGHRIC   200
201   LALESIISEE   ERKTRSAPFF   PIIIGRKPG       250

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
592_SER PHE gnomAD
chr4:128811336 		rs141081905
- 0.000131488 -
599_LEU TER ClinVar
chr4:128811357 		-
Pathogenic - not provided [MedGen:C3661900]
674_SER ARG 8.3kJPN
chr4:128812820 		-
- 0.0001 -
682_TYR CYS 8.3kJPN
chr4:128813526 		rs778017185
- 0.0004 -
716_GLU ASP 8.3kJPN
chr4:128813629 		-
- 0.0001 -
731_VAL ILE 8.3kJPN
chr4:128814442 		rs1560699717
- 0.0001 -
749_SER ALA 8.3kJPN
chr4:128814496 		-
- 0.0001 -
775_GLY SER 8.3kJPN
chr4:128814668 		rs765323092
- 0.0001 -
777_ARG HIS gnomAD
chr4:128814675 		rs200662248
- 0.000232868 -
801_ILE VAL gnomAD
chr4:128814746 		rs142713113
- 0.000168267 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.