| PDB ID | 4N7V
|
CHAIN | A |
|---|---|---|---|
| Protein name | Serine/threonine-protein kinase PLK4 | ||
| Uniprot Accession | O00444 | ||
| The number of similar proteins | 12 | ||
| The number of binding states | 4 | ||
| The number of binding partners | 4 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
Downdload
Molecule viewer
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Only interaction residues |
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Sequence information
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Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 592_SER | PHE |
gnomAD chr4:128811336 rs141081905 |
- | 0.000131488 | 0.1394 | - | |
| 599_LEU | TER |
ClinVar chr4:128811357 - |
Pathogenic | - | - | not provided [MedGen:C3661900] | |
| 674_SER | ARG |
8.3kJPN chr4:128812820 - |
- | 0.0001 | 0.3685 | - | |
| 682_TYR | CYS |
8.3kJPN chr4:128813526 rs778017185 |
- | 0.0004 | 0.7004 | - | |
| 716_GLU | ASP |
8.3kJPN chr4:128813629 - |
- | 0.0001 | 0.915 | - | |
| 731_VAL | ILE |
8.3kJPN chr4:128814442 rs1560699717 |
- | 0.0001 | 0.097 | - | |
| 749_SER | ALA |
8.3kJPN chr4:128814496 - |
- | 0.0001 | 0.0737 | - | |
| 775_GLY | SER |
8.3kJPN chr4:128814668 rs765323092 |
- | 0.0001 | 0.1174 | - | |
| 777_ARG | HIS |
gnomAD chr4:128814675 rs200662248 |
- | 0.000232868 | 0.0727 | - | |
| 801_ILE | VAL |
gnomAD chr4:128814746 rs142713113 |
- | 0.000168267 | 0.0693 | - |