| PDB ID | 3VTV
|
CHAIN | A |
|---|---|---|---|
| Protein name | Optineurin, microtubule-associated proteins 1A/1B light chain 3B | ||
| Uniprot Accession | Q96CV9 | ||
| The number of similar proteins | 41 | ||
| The number of binding states | 7 | ||
| The number of binding partners | 4 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 3VTV (CHAIN: A) | |
| 1 | Monomeric state |
| 2 |
Q9GZQ8
|
| 3 |
Q5ZUV9
|
| 4 |
Q9Y4P1
|
| 5 |
Q9GZQ8
Q9GZQ8
|
| 6 |
Q0PF16
Q0PF16
|
| 7 |
Q9GZQ8
Q9GZQ8
Q9GZQ8
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 18_SER | LEU |
gnomAD chr16:87426041 rs536459957 |
- | 0.00125792 | - | - | |
| 18_SER | TRP |
8.3kJPN chr16:87426041 rs536459957 |
- | 0.0008 | - | - | |
| 29_GLU | LYS |
gnomAD chr12:117013787 rs192133007 |
- | 0.000135191 | - | - | |
| 35_VAL | ILE |
8.3kJPN chr16:87432438 - |
- | 0.0001 | - | - | |
| 37_LEU | PHE |
8.3kJPN chr12:117013811 - |
- | 0.0001 | - | - | |
| 40_GLU | GLN |
gnomAD chr16:87432453 rs113610787 |
- | 0.0060481 | - | - | |
| 42_HIS | TYR |
8.3kJPN chr20:33147050 - |
- | 0.0001 | - | - | |
| 47_PRO | SER |
8.3kJPN chr12:117013841 - |
- | 0.0001 | - | - | |
| 49_ILE | MET |
8.3kJPN chr16:87435786 rs1158904097 |
- | 0.0001 | - | - | |
| 53_TYR | HIS |
8.3kJPN chr12:117013859 rs200048902 |
- | 0.0078 | - | - | |
| 55_GLY | SER |
8.3kJPN chr16:87435802 rs200880487 |
- | 0.0001 | - | - | |
| 58_GLN | HIS |
8.3kJPN chr12:117013876 - |
- | 0.0001 | - | - | |
| 61_VAL | LEU |
8.3kJPN chr20:33147190 - |
- | 0.0001 | - | - | |
| 65_THR | SER |
gnomAD chr20:33147203 rs755865335 |
- | 0.000283569 | - | - | |
| 75_MET | LEU |
8.3kJPN chr12:117013925 - |
- | 0.0001 | - | - | |
| 80_LYS | GLU |
8.3kJPN chr16:87435877 rs760756783 |
- | 0.0001 | - | - | |
| 82_ILE | SER |
8.3kJPN chr20:33147254 - |
- | 0.0001 | - | - | |
| 83_ARG | THR |
gnomAD chr12:117013950 rs775368545 |
- | 0.000111334 | - | - | |
| 84_ARG | LYS |
gnomAD chr12:117013953 rs144234011 |
- | 0.00322073 | - | - | |
| 84_ARG | GLY |
8.3kJPN chr20:33147541 - |
- | 0.0001 | - | - | |
| 85_ARG | CYS |
8.3kJPN chr12:117013955 - |
- | 0.0001 | - | - | |
| 91_ASN | HIS |
8.3kJPN chr16:87436551 rs1420825485 |
- | 0.0004 | - | - | |
| 100_GLY | GLU |
8.3kJPN chr16:87436579 - |
- | 0.0001 | - | - | |
| 106_VAL | PHE |
8.3kJPN chr16:87436596 - |
- | 0.0001 | - | - | |
| 122_GLY | SER |
8.3kJPN chr20:33147655 rs1347928984 |
- | 0.0001 | - | - | |
| 127_VAL | ILE |
8.3kJPN chr12:117014081 - |
- | 0.0001 | - | - | |
| 128_CYS | TYR |
gnomAD chr12:117014085 rs111327250 |
- | 0.0059828 | - | - | |
| 128_TYR | CYS |
gnomAD chr16:87436663 rs200708875 |
- | 0.00128707 | - | - | |
| 132_GLU | VAL |
gnomAD chr12:117014097 rs142080200 |
- | 0.00322113 | - | - | |
| 133_THR | ALA |
gnomAD chr12:117014099 rs113585095 |
- | 0.00611404 | - | - |