| PDB ID | 3TGX
|
CHAIN | A |
|---|---|---|---|
| Protein name | Interleukin-21 receptor | ||
| Uniprot Accession | Q9HBE5 | ||
| The number of similar proteins | 5 | ||
| The number of binding states | 5 | ||
| The number of binding partners | 4 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 3TGX (CHAIN: A) | |
| 1 |
Q9HBE4
|
| 2 | Monomeric state |
| 3 |
P31785
Q9HBE4
|
| 4 |
7KQ7
7KQ7
|
| 5 |
P31785
9E2T
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 3_ASP | ASN |
8.3kJPN chr16:27445682 rs149169230 |
- | 0.0002 | 0.081 | - | |
| 5_VAL | ILE |
8.3kJPN chr16:27445688 rs201895589 |
- | 0.0002 | 0.0812 | - | |
| 24_HIS | TYR |
8.3kJPN chr16:27445745 rs749807140 |
- | 0.0001 | 0.0975 | - | |
| 27_THR | MET |
gnomAD chr16:27445755 rs137946070 |
- | 0.00446133 | 0.0759 | - | |
| 48_LEU | PHE |
8.3kJPN chr16:27448855 - |
- | 0.0001 | 0.2211 | - | |
| 51_SER | LEU |
8.3kJPN chr16:27448865 rs780430063 |
- | 0.0001 | 0.1209 | - | |
| 55_ALA | VAL |
8.3kJPN chr16:27448877 - |
- | 0.0001 | 0.125 | - | |
| 56_THR | LYS |
8.3kJPN chr16:27448880 - |
- | 0.0001 | 0.4753 | - | |
| 90_CYS | PHE |
8.3kJPN chr16:27448982 - |
- | 0.0001 | 0.6877 | - | |
| 107_VAL | MET |
8.3kJPN chr16:27454306 rs374621384 |
- | 0.0001 | 0.4411 | - | |
| 120_ARG | CYS |
gnomAD chr16:27454345 rs146177564 |
- | 0.000624846 | 0.1026 | - | |
| 120_ARG | CYS |
8.3kJPN chr16:27454345 rs146177564 |
- | 0.0051 | 0.1026 | - | |
| 126_PRO | SER |
8.3kJPN chr16:27454363 rs749503528 |
- | 0.0018 | 0.0949 | - | |
| 133_GLY | ASP |
8.3kJPN chr16:27454385 rs775935919 |
- | 0.0001 | 0.1129 | - | |
| 137_TYR | TER |
ClinVar chr16:27454398 rs2141306468 |
Pathogenic | - | - | Cryptosporidiosis-chronic cholangitis-liver disease syndrome [MONDO:MONDO:0014082,MedGen:C3554687,OMIM:615207,Orphanet:357329] | |
| 172_ARG | CYS |
VAR_014360
rs3093370 |
LB/B | - | 0.1348 | - | |
| 172_ARG | CYS |
gnomAD chr16:27455926 rs3093370 |
- | 0.000158512 | 0.1348 | - | |
| 182_ARG | LEU |
VAR_069899
rs397514685 |
LP/P | - | 0.868 | Immunodeficiency 56 (IMD56) [MIM:615207] | |
| 182_ARG | LEU |
ClinVar chr16:27455957 rs397514685 |
Pathogenic | - | 0.868 | Cryptosporidiosis-chronic cholangitis-liver disease syndrome [MONDO:MONDO:0014082,MedGen:C3554687,OMIM:615207,Orphanet:357329] | |
| 183_ALA | VAL |
gnomAD chr16:27455960 rs147673485 |
- | 0.00012989 | 0.509 | - | |
| 183_ALA | GLU |
8.3kJPN chr16:27455960 - |
- | 0.0001 | 0.9209 | - | |
| 186_MET | ILE |
gnomAD chr16:27455970 rs201566028 |
- | 0.000327251 | 0.2225 | - | |
| 200_ASP | ASN |
8.3kJPN chr16:27456010 rs1049770600 |
- | 0.0001 | 0.1043 | - |