PDB ID 3SCK     CHAIN A
Protein name Angiotensin-converting enzyme 2 chimera
Uniprot Accession Q56NL1
The number of similar proteins 78
The number of binding states 6
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3SCK (CHAIN: A)
1 P59594  
2 Monomeric state
3 Q9BYF1  
4 Q56NL1   P59594  
5 7E7E   7E7E  
6 Q9BYF1   Q6Q1S2  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   STTEELAKTF   LETFNYEAQE   LSYQSSVASW   NYNTNITEEN   VQNMNNAGDK   50
51   WSAFLKEQST   LAQTYPLQEI   QNLTVKLQLQ   ALQQNGSSVL   SEDKSKRLNT   100
101   ILNTMSTIYS   TGKVCNPDNP   QECLLLEPGL   NEIMANSLDY   NERLWAWESW   150
151   RSEVGKQLRP   LYEEYVVLKN   EMARANHYED   YGDYWRGDYE   VNGVDGYDYS   200
201   RGQLIEDVEH   TFEEIKPLYE   HLHAYVRAKL   MNAYPSYISP   IGCLPAHLLG   250
251   DMWGRFWTNL   YSLTVPFGQK   PNIDVTDAMV   DQAWDAQRIF   KEAEKFFVSV   300
301   GLPNMTQGFW   ENSMLTDPGN   VQKAVCHPTA   WDLGKGDFRI   LMCTKVTMDD   350
351   FLTAHHEMGH   IQYDMAYAAQ   PFLLRNGANE   GFHEAVGEIM   SLSAATPKHL   400
401   KSIGLLSPDF   QEDNETEINF   LLKQALTIVG   TLPFTYMLEK   WRWMVFKGEI   450
451   PKDQWMKKWW   EMKREIVGVV   EPVPHDETYC   DPASLFHVSN   DYSFIRYYTR   500
501   TLYQFQFQEA   LCQAAKHEGP   LHKCDISNST   EAGQKLFNML   RLGKSEPWTL   550
551   ALENVVGAKN   MNVRPLLNYF   EPLFTWLKDQ   NKNSFVGWST   DWSPYADHHH   600
601   HHH           650

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
19_SER PRO gnomAD
chrX:15618980
rs73635825
- 0.00025179 - -
26_LYS ARG gnomAD
chrX:15618958
rs4646116
- 0.00397098 - -
62_MET ILE 8.3kJPN
chrX:15618849
-
- 0.0001 - -
184_VAL ALA 8.3kJPN
chrX:15609868
rs758142853
- 0.001 - -
206_ASP GLY gnomAD
chrX:15607546
rs142443432
- 0.000290163 - -
211_GLY ARG gnomAD
chrX:15607532
rs148771870
- 0.0013223 - -
219_ARG CYS gnomAD
chrX:15607508
rs372272603
- 0.000322288 - -
220_GLY SER 8.3kJPN
chrX:15607505
rs774621083
- 0.0003 - -
341_LYS ARG gnomAD
chrX:15599392
rs138390800
- 0.00032679 - -
468_ILE VAL gnomAD
chrX:15593829
rs191860450
- 0.000863335 - -
468_ILE VAL 8.3kJPN
chrX:15593829
rs191860450
- 0.003 - -
470_LYS GLN 8.3kJPN
chrX:15593823
-
- 0.0001 - -
483_GLU GLN 8.3kJPN
chrX:15591584
-
- 0.0001 - -
501_ALA THR 8.3kJPN
chrX:15591530
rs140473595
- 0.0002 - -
505_HIS PRO 8.3kJPN
chrX:15591517
-
- 0.0001 - -
511_SER PRO 8.3kJPN
chrX:15591500
-
- 0.0004 - -
547_SER CYS gnomAD
chrX:15590348
rs373025684
- 0.000225114 - -
570_LEU SER 8.3kJPN
chrX:15589875
rs1305384714
- 0.0001 - -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.