PDB ID 3S2K     CHAIN A
Protein name Low-density lipoprotein receptor-related protein 6
Uniprot Accession O75581
The number of similar proteins 12
The number of binding states 7
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3S2K (CHAIN: A)
1 O75581   O94907  
2 Monomeric state
3 8DVM  
4 6H16  
5 O94907  
6 O94907   Q96MU8  
7 6H15   6H15  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   ADPEAFLLFS   RRADIRRISL   ETNNNNVAIP   LTGVKEASAL   DFDVTDNRIY   50
51   WTDISLKTIS   RAFMNGSALE   HVVEFGLDYP   EGMAVDWLGK   NLYWADTGTN   100
101   RIEVSKLDGQ   HRQVLVWKDL   DSPRALALDP   AEGFMYWTEW   GGKPKIDRAA   150
151   MDGSERTTLV   PNVGRANGLT   IDYAKRRLYW   TDLDTNLIES   SNMLGLNREV   200
201   IADDLPHPFG   LTQYQDYIYW   TDWSRRSIER   ANKTSGQNRT   IIQGHLDYVM   250
251   DILVFHSSRQ   SGWNECASSN   GHCSHLCLAV   PVGGFVCGCP   AHYSLNADNR   300
301   TCSAPTTFLL   FSQKSAINRM   VIDEQQSPDI   ILPIHSLRNV   RAIDYDPLDK   350
351   QLYWIDSRQN   MIRKAQEDGS   QGFTVVVSSV   PSQNLEIQPY   DLSIDIYSRY   400
401   IYWTCEATNV   INVTRLDGRS   VGVVLKGEQD   RPRAIVVNPE   KGYMYFTNLQ   450
451   ERSPKIERAA   LDGTEREVLF   FSGLSKPIAL   ALDSRLGKLF   WADSDLRRIE   500
501   SSDLSGANRI   VLEDSNILQP   VGLTVFENWL   YWIDKQQQMI   EKIDMTGREG   550
551   RTKVQARIAQ   LSDIHAVKEL   NLQEYRQHPC   AQDNGGCSHI   CLVKGDGTTR   600
601   CSCPMHLVLL   QDELSCGEPH   HHHHHHHHH       650

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
644_ARG TER ClinVar
chr12:12317329
-
Pathogenic - - not provided [MedGen:C3661900]
674_ASN SER gnomAD
chr12:12317238
rs560695053
- 0.000179254 0.1211 -
676_ILE VAL gnomAD
chr12:12317233
rs188649737
- 0.000151422 0.2113 -
681_ILE ARG 8.3kJPN
chr12:12317217
-
- 0.0001 0.9511 -
714_TRP CYS 8.3kJPN
chr12:12315264
-
- 0.0001 0.9993 -
716_GLY TRP gnomAD
chr12:12315260
rs148592779
- 0.000317969 0.9956 -
728_ARG TER ClinVar
chr12:12315224
rs1202176045
Pathogenic - - not provided [MedGen:C3661900]
735_ASP ASN gnomAD
chr12:12315203
rs149258721
- 0.000238591 0.3069 -
735_ASP ASN 8.3kJPN
chr12:12315203
rs149258721
- 0.0001 0.3069 -
740_GLN TER ClinVar
chr12:12315188
rs1591901585
Pathogenic - - Oligodontia|Tooth agenesis, selective, 7 [Human Phenotype Ontology:HP:0000677,Human Phenotype Ontology:HP:0000702,MedGen:C4082304|MONDO:MONDO:0014749,MedGen:C4225231,OMIM:616724,Orphanet:99798]; Coronary artery disease, autosomal dominant 2 [MONDO:MONDO:0012586,MedGen:C1970440,OMIM:610947]
817_SER CYS VAR_030350
rs2302686
LB/B - 0.53 -
817_SER CYS gnomAD
chr12:12312728
rs2302686
- 0.000879098 0.53 -
817_SER CYS 8.3kJPN
chr12:12312728
rs2302686
- 0.0035 0.53 -
867_THR ALA gnomAD
chr12:12311955
rs141458215
- 0.000131232 0.2813 -
890_TRP TER ClinVar
chr12:12311885
rs1555108264
Pathogenic - - not provided [MedGen:CN517202]
896_SER ARG 8.3kJPN
chr12:12311868
-
- - 0.4183 -
931_ALA VAL 8.3kJPN
chr12:12303972
-
- 0.0001 0.2099 -
933_THR MET 8.3kJPN
chr12:12303966
rs772208806
- 0.0001 0.1272 -
947_MET THR ClinVar
chr12:12303924
rs2136919683
Pathogenic - 0.9307 Tooth agenesis, selective, 7 [MONDO:MONDO:0014749,MedGen:C4225231,OMIM:616724,Orphanet:99798]
985_ARG TER ClinVar
chr12:12303811
rs745688776
Pathogenic - - not provided [MedGen:CN517202]
1026_ARG HIS gnomAD
chr12:12302005
rs146852380
- 0.000135243 0.1203 -
1026_ARG HIS 8.3kJPN
chr12:12302005
rs146852380
- 0.0001 0.1203 -
1032_CYS PHE ClinVar
chr12:12301987
-
Likely pathogenic - 0.9185 Tooth agenesis, selective, 7 [MONDO:MONDO:0014749,MedGen:C4225231,OMIM:616724,Orphanet:99798]
1036_ASN SER 8.3kJPN
chr12:12301975
rs143873199
- 0.0001 0.1511 -
1044_ASP ASN gnomAD
chr12:12301952
rs140182370
- 0.00057282 0.1401 -
1054_GLY SER 8.3kJPN
chr12:12301922
-
- 0.0001 0.1207 -
1060_ARG TER ClinVar
chr12:12301904
rs765274952
Pathogenic - - not provided [MedGen:CN517202]
1062_VAL ILE gnomAD
chr12:12301898
rs2302685
- 0.850934 - -
1062_VAL ILE 8.3kJPN
chr12:12301898
rs2302685
- 0.9493 - -
1075_ASN SER gnomAD
chr12:12300473
rs202124188
- 0.000183217 0.1627 -
1075_ASN SER 8.3kJPN
chr12:12300473
rs202124188
- 0.0001 0.1627 -
1093_ARG GLN 8.3kJPN
chr12:12300419
-
- 0.0001 0.5155 -
1093_ARG TRP 8.3kJPN
chr12:12300420
rs752896710
- 0.0001 0.8793 -
1112_ARG SER 8.3kJPN
chr12:12300361
-
- 0.0001 0.1387 -
1115_LYS ARG 8.3kJPN
chr12:12300353
rs774000955
- 0.0004 0.0908 -
1127_GLU GLY gnomAD
chr12:12300317
rs560813860
- 0.000334132 0.9714 -
1130_ASP ASN gnomAD
chr12:12300309
rs142845287
- 0.000481339 0.303 -
1135_ASN THR 8.3kJPN
chr12:12291462
-
- 0.0001 0.4933 -
1136_ARG TRP gnomAD
chr12:12291460
rs140962861
- 0.00015536 0.9607 -
1154_GLU LYS gnomAD
chr12:12291406
rs779768114
- 0.000131316 0.1317 -
1165_GLN TER 8.3kJPN
chr12:12291373
-
- 0.0001 - -
1175_ARG GLY 8.3kJPN
chr12:12291343
-
- 0.0001 0.1459 -
1176_GLU ALA gnomAD
chr12:12291339
rs145672862
- 0.000159106 0.1025 -
1196_GLU TER ClinVar
chr12:12291280
-
Likely pathogenic - - LRP6-related condition [-]
1209_GLN TER ClinVar
chr12:12288217
-
Pathogenic - - not provided [MedGen:C3661900]
1210_ASP TYR 8.3kJPN
chr12:12288214
rs372538850
- 0.0007 0.2163 -
1224_GLY SER 8.3kJPN
chr12:12288172
rs749736350
- 0.0001 0.2867 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.