PDB ID 3RO2     CHAIN A
Protein name G-protein-signaling modulator 2
Uniprot Accession Q8VDU0
The number of similar proteins 12
The number of binding states 6
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3RO2 (CHAIN: A)
1 Monomeric state
2 Q9P202  
3 Q5SYB0  
4 Q14CM0  
5 Q1MX18  
6 P81274   P81274   Q14980   Q14980  

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Only interaction residues
#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   GSASCLELAL   EGERLCKSGD   CRAGVSFFEA   AVQVGTEDLK   TLSAIYSQLG   50
51   NAYFYLHDYA   KALEYHHHDL   TLARTIGDQL   GEAKASGNLG   NTLKVLGNFD   100
101   EAIVCCQRHL   DISRELNDKV   GEARALYNLG   NVYHAKGKSF   GCPGPQDTGE   150
151   FPEDVRNALQ   AAVDLYEENL   SLVTALGDRA   AQGRAFGNLG   NTHYLLGNFR   200
201   DAVIAHEQRL   LIAKEFGDKA   AERRAYSNLG   NAYIFLGEFE   TASEYYKKTL   250
251   LLARQLKDRA   VEAQSCYSLG   NTYTLLQDYE   KAIDYHLKHL   AIAQELKDRI   300
301   GEGRACWSLG   NAYTALGNHD   QAMHFAEKHL   EISREVGD     350

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
19_GLU VAL 8.3kJPN
chr1:109439506 		-
- 0.0001 -
39_PHE LEU ClinVar
chr1:109439567 		rs755804651
Pathogenic/Likely pathogenic - Deafness|Hearing loss, autosomal recessive [MedGen:C0011053|MONDO:MONDO:0019588,MedGen:C1846647,OMIM:607197,OMIM:PS220290,Orphanet:90635,Orphanet:90636]
74_ALA PRO 8.3kJPN
chr1:109439670 		-
- 0.0001 -
94_GLU ASP 8.3kJPN
chr1:109440138 		-
- 0.0002 -
120_ARG TER ClinVar
chr1:109440214 		rs267606854
Pathogenic - Chudley-McCullough syndrome|Hearing loss, autosomal recessive [MONDO:MONDO:0011411,MedGen:C1858695,OMIM:604213,Orphanet:314597|MONDO:MONDO:0019588,MedGen:C1846647,OMIM:607197,OMIM:PS220290,Orphanet:90635,Orphanet:90636]
120_ARG GLN gnomAD
chr1:109440215 		rs41279678
- 0.0832305 -
196_ARG CYS 8.3kJPN
chr1:109441313 		rs1380637881
- 0.0001 -
196_ARG HIS 8.3kJPN
chr1:109441314 		rs146446929
- 0.0001 -
226_LYS GLU gnomAD
chr1:109441516 		rs142923222
- 0.000183543 -
244_ALA THR 8.3kJPN
chr1:109441570 		-
- 0.0002 -
266_ARG GLN 8.3kJPN
chr1:109444432 		rs77121685
- 0.0023 -
271_ARG TER ClinVar
chr1:109444446 		rs762285081
Pathogenic - Chudley-McCullough syndrome [MONDO:MONDO:0011411,MedGen:C1858695,OMIM:604213,Orphanet:314597]
271_ARG GLN gnomAD
chr1:109444447 		rs190381417
- 0.00170276 -
275_ALA SER 8.3kJPN
chr1:109444458 		rs753366137
- 0.0007 -
311_ARG TER ClinVar
chr1:109444566 		-
Likely pathogenic - not provided [MedGen:CN517202]
319_TRP TER ClinVar
chr1:109445771 		rs1060499797
Pathogenic - Hearing loss, autosomal recessive|Chudley-McCullough syndrome [MONDO:MONDO:0019588,MedGen:C1846647,OMIM:607197,OMIM:PS220290,Orphanet:90635,Orphanet:90636|MONDO:MONDO:0011411,MedGen:C1858695,OMIM:604213,Orphanet:314597]
333_GLN GLU 8.3kJPN
chr1:109445812 		rs1456625996
- 0.0005 -
334_ALA THR gnomAD
chr1:109445815 		rs727505313
- 0.000111469 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.