PDB ID 3JUA     CHAIN A
Protein name Transcriptional enhancer factor TEF-3
Uniprot Accession Q62296
The number of similar proteins 30
The number of binding states 6
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3JUA (CHAIN: A)
1 P46938  
2 Monomeric state
3 Q62296  
4 Q99NC0  
5 Q80V24  
6 Q15561   P46937  

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Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   SMRSIASSKL   WMLEFSAFLE   RQQDPDTYNK   HLFVHISQSS   PSYSDPYLET   50
51   VDIRQIYDKF   PEKKGGLKEL   FERGPSNAFF   LVKFWADLNT   NIDDEGSAFY   100
101   GVSSQYESPE   NMIITCSTKV   CSFGKQVVEK   VETEYARYEN   GHYLYRIHRS   150
151   PLCEYMINFI   HKLKHLPEKY   MMNSVLENFT   ILQVVTNRDT   QETLLCIAYV   200
201   FEVSASEHGA   QHHIYRLVKE         250

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
210_ARG CYS 8.3kJPN
chr11:12904598 		rs375371397
- 0.0001 -
212_VAL MET gnomAD
chr12:3129871 		rs367723028
- 0.00027783 -
213_ALA VAL 8.3kJPN
chr12:3129875 		-
- 0.0001 -
218_ARG HIS gnomAD
chr11:12904623 		rs188077520
- 0.000218702 -
218_ARG HIS 8.3kJPN
chr11:12904623 		rs188077520
- 0.0124 -
232_PRO LEU gnomAD
chr12:3129932 		rs71583736
- 0.010958 -
232_PRO LEU 8.3kJPN
chr12:3129932 		rs71583736
- 0.0003 -
234_SER LEU 8.3kJPN
chr11:12904671 		rs140310944
- 0.0001 -
237_LYS GLU 8.3kJPN
chr12:3131016 		-
- 0.0001 -
241_VAL GLU 8.3kJPN
chr12:3131029 		rs1415302307
- 0.0001 -
256_GLU LYS 8.3kJPN
chr12:3131073 		rs762656664
- 0.0002 -
260_ILE VAL 8.3kJPN
chr12:3131085 		rs761078905
- 0.0001 -
261_ARG CYS gnomAD
chr12:3131088 		rs141718322
- 0.0014752 -
264_TYR CYS 8.3kJPN
chr12:3131098 		rs765302453
- 0.0001 -
272_GLY SER 8.3kJPN
chr12:3131121 		-
- 0.0001 -
279_GLU LYS 8.3kJPN
chr12:3131142 		-
- 0.0001 -
281_GLY CYS 8.3kJPN
chr11:12923625 		-
- 0.0001 -
284_ASN ASP 8.3kJPN
chr12:3131157 		-
- 0.0001 -
289_VAL ILE 8.3kJPN
chr11:12923649 		rs1243570522
- 0.0001 -
316_PRO SER gnomAD
chr12:3147203 		rs11550887
- 0.0377523 -
316_PRO SER 8.3kJPN
chr12:3147203 		rs11550887
- 0.0006 -
317_GLU LYS 8.3kJPN
chr12:3147206 		rs987014448
- 0.0001 -
322_THR ILE gnomAD
chr12:3147222 		rs200483208
- 0.00041392 -
323_CYS SER gnomAD
chr12:3147225 		rs371946304
- 0.000302507 -
344_ARG CYS gnomAD
chr12:3149285 		rs143259791
- 0.000354153 -
353_ARG CYS gnomAD
chr12:3149312 		rs148295237
- 0.000174978 -
353_ARG GLN 8.3kJPN
chr11:12951761 		-
- 0.0001 -
353_ARG HIS 8.3kJPN
chr12:3149313 		rs1172939530
- 0.0002 -
356_ARG GLN 8.3kJPN
chr12:3149322 		rs1326238086
- 0.0001 -
359_MET VAL 8.3kJPN
chr11:12951778 		rs764902614
- 0.0001 -
384_GLU GLY 8.3kJPN
chr11:12951854 		-
- 0.0001 -
391_VAL LEU 8.3kJPN
chr11:12958656 		rs549211479
- 0.0001 -
398_GLN ARG 8.3kJPN
chr12:3149553 		rs1279803067
- 0.0001 -
412_ASN SER 8.3kJPN
chr11:12958720 		-
- 0.0001 -
422_TYR HIS ClinVar
chr11:12958749 		rs11567847
Pathogenic - Helicoid peripapillary chorioretinal degeneration [MONDO:MONDO:0007176,MedGen:C1862382,OMIM:108985,Orphanet:86813]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.