PDB ID 3GB8     CHAIN A
Protein name Exportin-1
Uniprot Accession O14980
The number of similar proteins 12
The number of binding states 6
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3GB8 (CHAIN: A)
1 O95149  
2 Monomeric state
3 P62826  
4 O95149   P62826  
5 Q6P5F9   O95149   P62826  
6 P0AEX9   O95149   P62826  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   MPAIMTMLAD   HAARQLLDFS   QKLDINLLDN   VVNCLYHGEG   AQQRMAQEVL   50
51   THLKEHPDAW   TRVDTILEFS   QNMNTKYYGL   QILENVIKTR   WKILPRNQCE   100
101   GIKKYVVGLI   IKTSSDPTCV   EKEKVYIGKL   NMILVQILKQ   EWPKHWPTFI   150
151   SDIVGASRTS   ESLCQNNMVI   LKLLSEEVFD   FSSGQITQVK   SKHLKDSMCN   200
201   EFSQIFQLCQ   FVMENSQNAP   LVHATLETLL   RFLNWIPLGY   IFETKLISTL   250
251   IYKFLNVPMF   RNVSLKCLTE   IAGVSVSQYE   EQFVTLFTLT   MMQLKQMLPL   300
301   NTNIRLAYSN   GKDDEQNFIQ   NLSLFLCTFL   KEHDQLIEKR   LNLRETLMEA   350
351   LHYMLLVSEV   EETEIFKICL   EYWNHLAAEL   YRESPFSTSA   SPLLSGSQHF   400
401   DVPPRRQLYL   PMLFKVRLLM   VSRMAKPEEV   LVVENDQGEV   VREFMKDTDS   450
451   INLYKNMRET   LVYLTHLDYV   DTERIMTEKL   HNQVNGTEWS   WKNLNTLCWA   500
501   IGSISGAMHE   EDEKRFLVTV   IKDLLGLCEQ   KRGKDNKAII   ASNIMYIVGQ   550
551   YPRFLRAHWK   FLKTVVNKLF   EFMHETHDGV   QDMACDTFIK   IAQKCRRHFV   600
601   QVQVGEVMPF   IDEILNNINT   IICDLQPQQV   HTFYEAVGYM   IGAQTDQTVQ   650
651   EHLIEKYMLL   PNQVWDSIIQ   QATKNVDILK   DPETVKQLGS   ILKTNVRACK   700
701   AVGHPFVIQL   GRIYLDMLNV   YKCLSENISA   AIQANGEMVT   KQPLIRSMRT   750
751   VKRETLKLIS   GWVSRSNDPQ   MVAENFVPPL   LDAVLIDYQR   NVPAAREPEV   800
801   LSTMAIIVNK   LGGHITAEIP   QIFDAVFECT   LNMINKDFEE   YPEHRTNFFL   850
851   LLQAVNSHCF   PAFLAIPPTQ   FKLVLDSIIW   AFKHTMRNVA   DTGLQILFTL   900
901   LQNVAQEEAA   AQSFYQTYFC   DILQHIFSVV   TDTSHTAGLT   MHASILAYMF   950
951   NLVEEGKIST   SLNPGNPVNN   QIFLQEYVAN   LLKSAFPHLQ   DAQVKLFVTG   1000
1001   LFSLNQDIPA   FKEHLRDFLV   QIKEFAGEDT   SDLFLEEREI   ALRQADEEKH   1050
1051   KRQMSVPGIF   NPHEIPEEMC   D       1100

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
200_ASN SER 8.3kJPN
chr2:61726040
rs1051821670
- 0.0001 0.0543 -
203_SER LEU 8.3kJPN
chr2:61726031
-
- 0.0001 0.4014 -
271_ILE VAL 8.3kJPN
chr2:61724091
-
- 0.0001 0.1584 -
539_ILE VAL 8.3kJPN
chr2:61719568
rs758975202
- 0.0001 0.1584 -
571_GLU LYS ClinVar
chr2:61719472
rs1057520009
Likely pathogenic - 0.9997 Neoplasm of the large intestine|Prostate adenocarcinoma|Malignant neoplasm of body of uterus|Breast neoplasm|B-cell chronic lymphocytic leukemia [Human Phenotype Ontology:HP:0100834,MONDO:MONDO:0005335,MeSH:D015179,MedGen:C0009404|MONDO:MONDO:0005082,MedGen:C0007112|MedGen:C0153574|Human Phenotype Ontology:HP:0010623,Human Phenotype Ontology:HP:0100013,MONDO:MONDO:0021100,MeSH:D001943,MedGen:C1458155|Human Phenotype Ontology:HP:0005550,Human Phenotype Ontology:HP:0006734,Human Phenotype Ontology:HP:0006760,MONDO:MONDO:0004948,MeSH:D015451,MedGen:C0023434,OMIM:151400,Orphanet:67038]
571_GLU VAL ClinVar
chr2:61719471
rs1057520010
Likely pathogenic - 0.9989 Prostate adenocarcinoma|Breast neoplasm|B-cell chronic lymphocytic leukemia|Malignant neoplasm of body of uterus|Neoplasm of the large intestine [MONDO:MONDO:0005082,MedGen:C0007112|Human Phenotype Ontology:HP:0010623,Human Phenotype Ontology:HP:0100013,MONDO:MONDO:0021100,MeSH:D001943,MedGen:C1458155|Human Phenotype Ontology:HP:0005550,Human Phenotype Ontology:HP:0006734,Human Phenotype Ontology:HP:0006760,MONDO:MONDO:0004948,MeSH:D015451,MedGen:C0023434,OMIM:151400,Orphanet:67038|MedGen:C0153574|Human Phenotype Ontology:HP:0100834,MONDO:MONDO:0005335,MeSH:D015179,MedGen:C0009404]
571_GLU ALA ClinVar
chr2:61719471
rs1057520010
Likely pathogenic - 0.997 Malignant neoplasm of body of uterus|Prostate adenocarcinoma|Breast neoplasm|Neoplasm of the large intestine|B-cell chronic lymphocytic leukemia [MedGen:C0153574|MONDO:MONDO:0005082,MedGen:C0007112|Human Phenotype Ontology:HP:0010623,Human Phenotype Ontology:HP:0100013,MONDO:MONDO:0021100,MeSH:D001943,MedGen:C1458155|Human Phenotype Ontology:HP:0100834,MONDO:MONDO:0005335,MeSH:D015179,MedGen:C0009404|Human Phenotype Ontology:HP:0005550,Human Phenotype Ontology:HP:0006734,Human Phenotype Ontology:HP:0006760,MONDO:MONDO:0004948,MeSH:D015451,MedGen:C0023434,OMIM:151400,Orphanet:67038]
653_LEU VAL 8.3kJPN
chr2:61717842
-
- 0.0001 0.4194 -
659_LEU SER 8.3kJPN
chr2:61717823
-
- 0.0001 0.1465 -
767_ASN SER gnomAD
chr2:61715313
rs146348437
- 0.000135302 0.0532 -
767_ASN SER 8.3kJPN
chr2:61715313
rs146348437
- 0.0001 0.0532 -
856_ASN SER 8.3kJPN
chr2:61711182
rs768499033
- 0.0001 0.1162 -
915_TYR HIS 8.3kJPN
chr2:61710161
rs764886204
- 0.0001 0.5593 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.