| PDB ID | 3E4Z
|
CHAIN | A |
|---|---|---|---|
| Protein name | Insulin-degrading enzyme | ||
| Uniprot Accession | Q5T5N2 | ||
| The number of similar proteins | 63 | ||
| The number of binding states | 14 | ||
| The number of binding partners | 11 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 3E4Z (CHAIN: A) | |
| 1 |
P01344
|
| 2 | Monomeric state |
| 3 |
P01308
|
| 4 |
P10147
|
| 5 |
P16860
|
| 6 |
P14735
|
| 7 |
P0CG48
|
| 8 |
P10997
|
| 9 |
P01135
|
| 10 |
2G47
|
| 11 |
4M1C
P05067
|
| 12 |
5CJO
5CJO
|
| 13 |
P14735
5WOB
|
| 14 |
5UOE
5UOE
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 50_ILE | THR |
8.3kJPN chr10:94297257 rs780598235 |
- | 0.0009 | - | - | |
| 51_GLY | ARG |
8.3kJPN chr10:94297255 - |
- | 0.0001 | - | - | |
| 66_GLY | GLU |
8.3kJPN chr10:94297209 - |
- | 0.0001 | - | - | |
| 67_LEU | PRO |
8.3kJPN chr10:94297206 - |
- | 0.0001 | - | - | |
| 128_SER | ASN |
gnomAD chr10:94294443 rs528804574 |
- | 0.000246684 | - | - | |
| 181_ARG | LYS |
8.3kJPN chr10:94291624 rs1346925336 |
- | 0.0001 | - | - | |
| 191_GLU | LYS |
8.3kJPN chr10:94291595 - |
- | 0.0001 | - | - | |
| 202_PHE | LEU |
8.3kJPN chr10:94291562 - |
- | 0.0001 | - | - | |
| 212_LYS | ASN |
gnomAD chr10:94291530 rs116003953 |
- | 0.00093918 | - | - | |
| 235_ILE | VAL |
8.3kJPN chr10:94274758 - |
- | 0.0001 | - | - | |
| 254_MET | THR |
gnomAD chr10:94274700 rs200118524 |
- | 0.000111665 | - | - | |
| 260_GLY | SER |
gnomAD chr10:94274683 rs192563243 |
- | 0.00016069 | - | - | |
| 260_GLY | SER |
8.3kJPN chr10:94274683 rs192563243 |
- | 0.0008 | - | - | |
| 276_SER | ALA |
8.3kJPN chr10:94269878 - |
- | 0.0001 | - | - | |
| 381_GLU | ASP |
gnomAD chr10:94267880 rs200246238 |
- | 0.000112052 | - | - | |
| 402_ARG | LEU |
8.3kJPN chr10:94267372 rs775329426 |
- | 0.0007 | - | - | |
| 443_TYR | HIS |
8.3kJPN chr10:94264654 rs1275159763 |
- | 0.0001 | - | - | |
| 477_ARG | TRP |
8.3kJPN chr10:94264552 rs759169186 |
- | 0.0001 | - | - | |
| 484_SER | CYS |
gnomAD chr10:94250332 rs117251230 |
- | 0.00130238 | - | - | |
| 484_SER | TYR |
8.3kJPN chr10:94250332 rs117251230 |
- | - | - | - | |
| 490_ASP | ASN |
8.3kJPN chr10:94250315 - |
- | - | - | - | |
| 498_THR | ILE |
8.3kJPN chr10:94250290 - |
- | 0.0003 | - | - | |
| 499_GLN | HIS |
8.3kJPN chr10:94250286 - |
- | 0.0001 | - | - | |
| 524_LEU | PHE |
8.3kJPN chr10:94247039 rs1471469075 |
- | 0.0004 | - | - | |
| 539_PRO | LEU |
8.3kJPN chr10:94246993 rs147012131 |
- | 0.0004 | - | - | |
| 560_TRP | ARG |
8.3kJPN chr10:94243073 - |
- | 0.0001 | - | - | |
| 644_LYS | ASN |
8.3kJPN chr10:94235704 - |
- | 0.0001 | - | - | |
| 662_ILE | MET |
gnomAD chr10:94235650 rs774291118 |
- | 0.000141085 | - | - | |
| 687_ARG | HIS |
8.3kJPN chr10:94234654 rs746163475 |
- | 0.0002 | - | - | |
| 722_ARG | GLN |
8.3kJPN chr10:94230054 rs1212879700 |
- | 0.0003 | - | - | |
| 722_ARG | TRP |
8.3kJPN chr10:94230055 rs76587725 |
- | 0.0001 | - | - | |
| 765_ARG | TRP |
8.3kJPN chr10:94228663 rs760053435 |
- | 0.0003 | - | - | |
| 778_VAL | LEU |
8.3kJPN chr10:94225589 - |
- | 0.0001 | - | - | |
| 865_ALA | THR |
8.3kJPN chr10:94223656 rs761870451 |
- | 0.0002 | - | - | |
| 878_THR | ALA |
gnomAD chr10:94223617 rs145451690 |
- | 0.000183009 | - | - | |
| 891_ILE | VAL |
8.3kJPN chr10:94223578 rs753087364 |
- | 0.0001 | - | - | |
| 916_TYR | CYS |
8.3kJPN chr10:94223502 rs1279397450 |
- | 0.0001 | - | - | |
| 936_ILE | THR |
8.3kJPN chr10:94220964 rs145220987 |
- | 0.0001 | - | - | |
| 956_VAL | ILE |
8.3kJPN chr10:94216146 rs375559999 |
- | 0.0016 | - | - | |
| 1010_PRO | LEU |
8.3kJPN chr10:94214232 - |
- | 0.0001 | - | - |