PDB ID 3E4Z     CHAIN A
Protein name Insulin-degrading enzyme
Uniprot Accession Q5T5N2
The number of similar proteins 63
The number of binding states 14
The number of binding partners 11

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
3E4Z (CHAIN: A)
1 P01344  
2 Monomeric state
3 P01308  
4 P10147  
5 P16860  
6 P14735  
7 P0CG48  
8 P10997  
9 P01135  
10 2G47  
11 4M1C   P05067  
12 5CJO   5CJO  
13 P14735   5WOB  
14 5UOE   5UOE  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  >9
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MHHHHHHAAG   IPMNNPAIKR   IGNHITKSPE   DKREYRGLEL   ANGIKVLLIS   50
51   DPTTDKSSAA   LDVHIGSLSD   PPNIAGLSHF   LQHMLFLGTK   KYPKENEYSQ   100
101   FLSEHAGSSN   AFTSGEHTNY   YFDVSHEHLE   GALDRFAQFF   LSPLFDESAK   150
151   DREVNAVDSE   HEKNVMNDAW   RLFQLEKATG   NPKHPFSKFG   TGNKYTLETR   200
201   PNQEGIDVRQ   ELLKFHSAYY   SSNLMAVVVL   GRESLDDLTN   LVVKLFSEVE   250
251   NKNVPLPEFP   EHPFQEEHLK   QLYKIVPIKD   IRNLYVTFPI   PDLQKYYKSN   300
301   PGHYLGHLIG   HEGPGSLLSE   LKSKGWVNTL   VGGQKEGARG   FMFFIINVDL   350
351   TEEGLLHVED   IILHMFQYIQ   KLRAEGPQEW   VFQELKDLNA   VAFRFKDKER   400
401   PRGYTSKIAG   ILHYYPLEEV   LTAEYLLEEF   RPDLIEMVLD   KLRPENVRVA   450
451   IVSKSFEGKT   DRTEEWYGTQ   YKQEAIPDEV   IKKWQNADLN   GKFKLPTKNE   500
501   FIPTNFEILP   LEKEATPYPA   LIKDTAMSKL   WFKQDDKFFL   PKANLNFEFF   550
551   SPFAYVDPLH   SNMAYLYLEL   LKDSLNEYAY   AAELAGLSYD   LQNTIYGMYL   600
601   SVKGYNDKQP   ILLKKIIEKM   ATFEIDEKRF   EIIKEAYMRS   LNNFRAEQPH   650
651   QHAMYYLRLL   MTEVAWTKDE   LKEALDDVTL   PRLKAFIPQL   LSRLHIEALL   700
701   HGNITKQAAL   GIMQMVEDTL   IEHAHTKPLL   PSQLVRYREV   QLPDRGWFVY   750
751   QQRNEVHNNS   GIEIYYQTDM   QSTSENMFLE   LFAQIISEPA   FNTLRTKEQL   800
801   GYIVFSGPRR   ANGIQGLRFI   IQSEKPPHYL   ESRVEAFLIT   MEKSIEDMTE   850
851   EAFQKHIQAL   AIRRLDKPKK   LSAESAKYYG   EIISQQYNFD   RDNTEVAYLK   900
901   TLTKEDIIKF   YKEMLAVDAP   RRHKVSVHVL   AREMDSCPVV   GEFPCQNDIN   950
951   LSQAPALPQP   EVIQNMTEFK   RGLPLFPLVK   PHINFMAAKL     1000

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
50_ILE THR 8.3kJPN
chr10:94297257 		rs780598235
- 0.0009 -
51_GLY ARG 8.3kJPN
chr10:94297255 		-
- 0.0001 -
66_GLY GLU 8.3kJPN
chr10:94297209 		-
- 0.0001 -
67_LEU PRO 8.3kJPN
chr10:94297206 		-
- 0.0001 -
128_SER ASN gnomAD
chr10:94294443 		rs528804574
- 0.000246684 -
181_ARG LYS 8.3kJPN
chr10:94291624 		rs1346925336
- 0.0001 -
191_GLU LYS 8.3kJPN
chr10:94291595 		-
- 0.0001 -
202_PHE LEU 8.3kJPN
chr10:94291562 		-
- 0.0001 -
212_LYS ASN gnomAD
chr10:94291530 		rs116003953
- 0.00093918 -
235_ILE VAL 8.3kJPN
chr10:94274758 		-
- 0.0001 -
254_MET THR gnomAD
chr10:94274700 		rs200118524
- 0.000111665 -
260_GLY SER gnomAD
chr10:94274683 		rs192563243
- 0.00016069 -
260_GLY SER 8.3kJPN
chr10:94274683 		rs192563243
- 0.0008 -
276_SER ALA 8.3kJPN
chr10:94269878 		-
- 0.0001 -
381_GLU ASP gnomAD
chr10:94267880 		rs200246238
- 0.000112052 -
402_ARG LEU 8.3kJPN
chr10:94267372 		rs775329426
- 0.0007 -
443_TYR HIS 8.3kJPN
chr10:94264654 		rs1275159763
- 0.0001 -
477_ARG TRP 8.3kJPN
chr10:94264552 		rs759169186
- 0.0001 -
484_SER CYS gnomAD
chr10:94250332 		rs117251230
- 0.00130238 -
484_SER TYR 8.3kJPN
chr10:94250332 		rs117251230
- - -
490_ASP ASN 8.3kJPN
chr10:94250315 		-
- - -
498_THR ILE 8.3kJPN
chr10:94250290 		-
- 0.0003 -
499_GLN HIS 8.3kJPN
chr10:94250286 		-
- 0.0001 -
524_LEU PHE 8.3kJPN
chr10:94247039 		rs1471469075
- 0.0004 -
539_PRO LEU 8.3kJPN
chr10:94246993 		rs147012131
- 0.0004 -
560_TRP ARG 8.3kJPN
chr10:94243073 		-
- 0.0001 -
644_LYS ASN 8.3kJPN
chr10:94235704 		-
- 0.0001 -
662_ILE MET gnomAD
chr10:94235650 		rs774291118
- 0.000141085 -
687_ARG HIS 8.3kJPN
chr10:94234654 		rs746163475
- 0.0002 -
722_ARG GLN 8.3kJPN
chr10:94230054 		rs1212879700
- 0.0003 -
722_ARG TRP 8.3kJPN
chr10:94230055 		rs76587725
- 0.0001 -
765_ARG TRP 8.3kJPN
chr10:94228663 		rs760053435
- 0.0003 -
778_VAL LEU 8.3kJPN
chr10:94225589 		-
- 0.0001 -
865_ALA THR 8.3kJPN
chr10:94223656 		rs761870451
- 0.0002 -
878_THR ALA gnomAD
chr10:94223617 		rs145451690
- 0.000183009 -
891_ILE VAL 8.3kJPN
chr10:94223578 		rs753087364
- 0.0001 -
916_TYR CYS 8.3kJPN
chr10:94223502 		rs1279397450
- 0.0001 -
936_ILE THR 8.3kJPN
chr10:94220964 		rs145220987
- 0.0001 -
956_VAL ILE 8.3kJPN
chr10:94216146 		rs375559999
- 0.0016 -
1010_PRO LEU 8.3kJPN
chr10:94214232 		-
- 0.0001 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.