PDB ID 2OK5     CHAIN A
Protein name Complement factor B
Uniprot Accession P00751
The number of similar proteins 8
The number of binding states 5
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2OK5 (CHAIN: A)
1 Monomeric state
2 P01024   P01024  
3 Q91132   Q91132   Q91132  
4 P27918   P01024   P01024  
5 P01024   P01024   P00746  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   GSHHHHHHGS   TPWSLARPQG   SCSLEGVEIK   GGSFRLLQEG   QALEYVCPSG   50
51   FYPYPVQTRT   CRSTGSWSTL   KTQDQKTVRK   AECRAIHCPR   PHDFENGEYW   100
101   PRSPYYNVSD   EISFHCYDGY   TLRGSANRTC   QVNGRWSGQT   AICDNGAGYC   150
151   SNPGIPIGTR   KVGSQYRLED   SVTYHCSRGL   TLRGSQRRTC   QEGGSWSGTE   200
201   PSCQDSFMYD   TPQEVAEAFL   SSLTETIEGV   DAEDGHGPGE   QQKRKIVLDP   250
251   SGSMNIYLVL   DGSDSIGASN   FTGAKKCLVN   LIEKVASYGV   KPRYGLVTYA   300
301   TYPKIWVKVS   EADSSNADWV   TKQLNEINYE   DHKLKSGTNT   KKALQAVYSM   350
351   MSWPDDVPPE   GWNRTRHVII   LMTDGLHNMG   GDPITVIDEI   RDLLYIGKDR   400
401   KNPREDYLDV   YVFGVGPLVN   QVNINALASK   KDNEQHVFKV   KDMENLEDVF   450
451   YQMIDESQSL   SLCGMVWEHR   KGTDYHKQPW   QAKISVIRPS   KGHESCMGAV   500
501   VSEYFVLTAA   HCFTVDDKEH   SIKVSVGGEK   RDLEIEVVLF   HPNYNINGKK   550
551   EAGIPEFYDY   DVALIKLKNK   LKYGQTIRPI   CLPCTEGTTR   ALRLPPTTTC   600
601   QQQKEELLPA   QDIKALFVSE   EEKKLTRKEV   YIKNGDKKGS   CERDAQYAPG   650
651   YDKVKDISEV   VTPRFLCTGG   VSPYADPNTC   RGDSGGPLIV   HKRSRFIQVG   700
701   VISWGVVDVC   KNQKRQKQVP   AHARDFHINL   FQVLPWLKEK   LQDEDLGFLA   750
751   AA           800

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
17_VAL GLU 8.3kJPN
chr6:31914210 		-
- 0.0001 -
49_ARG HIS gnomAD
chr6:31914306 		rs117314762
- 0.000770529 -
49_ARG HIS 8.3kJPN
chr6:31914306 		rs117314762
- 0.02 -
118_ARG CYS 8.3kJPN
chr6:31914912 		rs1242945827
- 0.0001 -
118_ARG HIS 8.3kJPN
chr6:31914913 		rs559980890
- 0.0001 -
141_SER PRO VAR_063659 -
LP/P - Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
157_ARG CYS 8.3kJPN
chr6:31915184 		rs1446329739
- 0.0001 -
178_ARG GLN VAR_063660 rs745794224
LP/P - Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
189_THR MET 8.3kJPN
chr6:31915281 		rs761471751
- 0.0001 -
201_THR ILE 8.3kJPN
chr6:31915537 		rs763140485
- 0.0001 -
207_GLU LYS 8.3kJPN
chr6:31915554 		rs141965248
- 0.0002 -
217_ILE LEU VAR_063661 rs144812066
LP/P - Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
217_ILE LEU gnomAD
chr6:31915584 		rs144812066
- 0.000972262 -
217_ILE THR 8.3kJPN
chr6:31915585 		rs747955294
- 0.0001 -
237_VAL ILE 8.3kJPN
chr6:31915745 		rs200645483
- 0.0001 -
254_ASP GLU gnomAD
chr6:31915798 		rs147564718
- 0.000202812 -
256_ILE THR 8.3kJPN
chr6:31915803 		rs745324553
- 0.0001 -
261_PHE LEU VAR_063221 rs117905900
LP/P - Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
261_PHE LEU ClinVar
chr6:31915817 		-
Pathogenic - CFB-related disorders [-]
278_TYR CYS 8.3kJPN
chr6:31916161 		-
- 0.0001 -
298_LYS GLU VAR_063222 rs121909748
LP/P - Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
298_LYS GLN VAR_063662 -
LP/P - Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
301_GLU ASP gnomAD
chr6:31916231 		rs140166479
- 0.000712024 -
306_ASN ASP 8.3kJPN
chr6:31916244 		rs776825572
- 0.0012 -
311_THR MET 8.3kJPN
chr6:31916260 		rs534721289
- 0.0001 -
353_ASN THR gnomAD
chr6:31916703 		rs372853357
- 0.000271016 -
378_ASP GLU 8.3kJPN
chr6:31917060 		-
- 0.0001 -
390_ARG CYS 8.3kJPN
chr6:31917094 		rs535712398
- 0.0001 -
392_ASN SER 8.3kJPN
chr6:31917101 		rs778914840
- 0.0001 -
432_ASP ASN 8.3kJPN
chr6:31917295 		-
- 0.0001 -
433_MET ILE VAR_063663 rs200837114
LP/P - Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
445_ASP ASN 8.3kJPN
chr6:31917334 		rs771402308
- 0.0001 -
477_ILE THR 8.3kJPN
chr6:31917923 		rs765136717
- 0.0001 -
485_SER ARG 8.3kJPN
chr6:31918084 		-
- 0.0001 -
508_LYS ARG VAR_063664 rs149101394
LP/P - Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
508_LYS ARG gnomAD
chr6:31918154 		rs149101394
- 0.00907619 -
521_ARG TRP 8.3kJPN
chr6:31918407 		rs745920524
- 0.0001 -
540_LYS GLU VAR_016277 rs4151659
LB/B - -
540_LYS GLU gnomAD
chr6:31918464 		rs4151659
- 0.0107402 -
541_GLU ALA gnomAD
chr6:31918468 		rs45484591
- 0.0110888 -
541_GLU ALA 8.3kJPN
chr6:31918468 		rs45484591
- 0.0003 -
545_PRO SER 8.3kJPN
chr6:31918479 		-
- 0.0001 -
592_GLN HIS 8.3kJPN
chr6:31918717 		-
- 0.0001 -
617_ARG GLN 8.3kJPN
chr6:31918990 		rs773667445
- 0.0001 -
626_ASP GLU VAR_016278 rs4151660
LB/B - -
626_ASP GLU gnomAD
chr6:31919018 		rs4151660
- 0.00180321 -
631_CYS GLY 8.3kJPN
chr6:31919127 		-
- 0.0001 -
639_PRO SER 8.3kJPN
chr6:31919151 		-
- 0.0001 -
654_ARG TRP 8.3kJPN
chr6:31919196 		-
- 0.0001 -
691_VAL LEU 8.3kJPN
chr6:31919658 		rs777891193
- 0.0004 -
711_ALA SER VAR_006495 -
LB/B - -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.