PDB ID 2OK5     CHAIN A
Protein name Complement factor B
Uniprot Accession P00751
The number of similar proteins 8
The number of binding states 5
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2OK5 (CHAIN: A)
1 Monomeric state
2 P01024   P01024  
3 Q91132   Q91132   Q91132  
4 P27918   P01024   P01024  
5 P01024   P01024   P00746  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   GSHHHHHHGS   TPWSLARPQG   SCSLEGVEIK   GGSFRLLQEG   QALEYVCPSG   50
51   FYPYPVQTRT   CRSTGSWSTL   KTQDQKTVRK   AECRAIHCPR   PHDFENGEYW   100
101   PRSPYYNVSD   EISFHCYDGY   TLRGSANRTC   QVNGRWSGQT   AICDNGAGYC   150
151   SNPGIPIGTR   KVGSQYRLED   SVTYHCSRGL   TLRGSQRRTC   QEGGSWSGTE   200
201   PSCQDSFMYD   TPQEVAEAFL   SSLTETIEGV   DAEDGHGPGE   QQKRKIVLDP   250
251   SGSMNIYLVL   DGSDSIGASN   FTGAKKCLVN   LIEKVASYGV   KPRYGLVTYA   300
301   TYPKIWVKVS   EADSSNADWV   TKQLNEINYE   DHKLKSGTNT   KKALQAVYSM   350
351   MSWPDDVPPE   GWNRTRHVII   LMTDGLHNMG   GDPITVIDEI   RDLLYIGKDR   400
401   KNPREDYLDV   YVFGVGPLVN   QVNINALASK   KDNEQHVFKV   KDMENLEDVF   450
451   YQMIDESQSL   SLCGMVWEHR   KGTDYHKQPW   QAKISVIRPS   KGHESCMGAV   500
501   VSEYFVLTAA   HCFTVDDKEH   SIKVSVGGEK   RDLEIEVVLF   HPNYNINGKK   550
551   EAGIPEFYDY   DVALIKLKNK   LKYGQTIRPI   CLPCTEGTTR   ALRLPPTTTC   600
601   QQQKEELLPA   QDIKALFVSE   EEKKLTRKEV   YIKNGDKKGS   CERDAQYAPG   650
651   YDKVKDISEV   VTPRFLCTGG   VSPYADPNTC   RGDSGGPLIV   HKRSRFIQVG   700
701   VISWGVVDVC   KNQKRQKQVP   AHARDFHINL   FQVLPWLKEK   LQDEDLGFLA   750
751   AA           800

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
17_VAL GLU 8.3kJPN
chr6:31914210
-
- 0.0001 0.2896 -
49_ARG HIS gnomAD
chr6:31914306
rs117314762
- 0.000770529 0.4734 -
49_ARG HIS 8.3kJPN
chr6:31914306
rs117314762
- 0.02 0.4734 -
118_ARG CYS 8.3kJPN
chr6:31914912
rs1242945827
- 0.0001 0.8373 -
118_ARG HIS 8.3kJPN
chr6:31914913
rs559980890
- 0.0001 0.4667 -
141_SER PRO VAR_063659
-
LP/P - 0.0393 Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
157_ARG CYS 8.3kJPN
chr6:31915184
rs1446329739
- 0.0001 0.4567 -
178_ARG GLN VAR_063660
rs745794224
LP/P - 0.4657 Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
189_THR MET 8.3kJPN
chr6:31915281
rs761471751
- 0.0001 0.1298 -
201_THR ILE 8.3kJPN
chr6:31915537
rs763140485
- 0.0001 0.1872 -
207_GLU LYS 8.3kJPN
chr6:31915554
rs141965248
- 0.0002 0.1055 -
217_ILE LEU VAR_063661
rs144812066
LP/P - 0.1484 Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
217_ILE LEU gnomAD
chr6:31915584
rs144812066
- 0.000972262 0.1484 -
217_ILE THR 8.3kJPN
chr6:31915585
rs747955294
- 0.0001 0.4222 -
237_VAL ILE 8.3kJPN
chr6:31915745
rs200645483
- 0.0001 0.0704 -
254_ASP GLU gnomAD
chr6:31915798
rs147564718
- 0.000202812 0.2527 -
256_ILE THR 8.3kJPN
chr6:31915803
rs745324553
- 0.0001 0.2711 -
261_PHE LEU VAR_063221
rs117905900
LP/P - 0.9765 Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
261_PHE LEU ClinVar
chr6:31915817
-
Pathogenic - 0.9765 CFB-related disorders [-]
278_TYR CYS 8.3kJPN
chr6:31916161
-
- 0.0001 0.7346 -
298_LYS GLU VAR_063222
rs121909748
LP/P - 0.1691 Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
298_LYS GLN VAR_063662
-
LP/P - 0.1452 Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
301_GLU ASP gnomAD
chr6:31916231
rs140166479
- 0.000712024 0.064 -
306_ASN ASP 8.3kJPN
chr6:31916244
rs776825572
- 0.0012 0.0554 -
311_THR MET 8.3kJPN
chr6:31916260
rs534721289
- 0.0001 0.0987 -
353_ASN THR gnomAD
chr6:31916703
rs372853357
- 0.000271016 0.428 -
378_ASP GLU 8.3kJPN
chr6:31917060
-
- 0.0001 0.0937 -
390_ARG CYS 8.3kJPN
chr6:31917094
rs535712398
- 0.0001 0.4062 -
392_ASN SER 8.3kJPN
chr6:31917101
rs778914840
- 0.0001 0.2019 -
432_ASP ASN 8.3kJPN
chr6:31917295
-
- 0.0001 0.1058 -
433_MET ILE VAR_063663
rs200837114
LP/P - 0.3775 Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
445_ASP ASN 8.3kJPN
chr6:31917334
rs771402308
- 0.0001 0.2607 -
477_ILE THR 8.3kJPN
chr6:31917923
rs765136717
- 0.0001 0.0543 -
485_SER ARG 8.3kJPN
chr6:31918084
-
- 0.0001 0.2227 -
508_LYS ARG VAR_063664
rs149101394
LP/P - 0.0864 Hemolytic uremic syndrome atypical 4 (AHUS4) [MIM:612924]
508_LYS ARG gnomAD
chr6:31918154
rs149101394
- 0.00907619 0.0864 -
521_ARG TRP 8.3kJPN
chr6:31918407
rs745920524
- 0.0001 0.118 -
540_LYS GLU VAR_016277
rs4151659
LB/B - 0.1276 -
540_LYS GLU gnomAD
chr6:31918464
rs4151659
- 0.0107402 0.1276 -
541_GLU ALA gnomAD
chr6:31918468
rs45484591
- 0.0110888 0.05 -
541_GLU ALA 8.3kJPN
chr6:31918468
rs45484591
- 0.0003 0.05 -
545_PRO SER 8.3kJPN
chr6:31918479
-
- 0.0001 0.0936 -
592_GLN HIS 8.3kJPN
chr6:31918717
-
- 0.0001 0.3015 -
617_ARG GLN 8.3kJPN
chr6:31918990
rs773667445
- 0.0001 0.1127 -
626_ASP GLU VAR_016278
rs4151660
LB/B - 0.0834 -
626_ASP GLU gnomAD
chr6:31919018
rs4151660
- 0.00180321 0.0834 -
631_CYS GLY 8.3kJPN
chr6:31919127
-
- 0.0001 0.9783 -
639_PRO SER 8.3kJPN
chr6:31919151
-
- 0.0001 0.0869 -
654_ARG TRP 8.3kJPN
chr6:31919196
-
- 0.0001 0.5185 -
691_VAL LEU 8.3kJPN
chr6:31919658
rs777891193
- 0.0004 0.4323 -
711_ALA SER VAR_006495
-
LB/B - 0.0748 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.