PDB ID 2NL9     CHAIN A
Protein name FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Uniprot Accession P97287
The number of similar proteins 116
The number of binding states 15
The number of binding partners 8

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2NL9 (CHAIN: A)
1 Monomeric state
2 P97287  
3 6QB3  
4 6ZIE  
5 5JSB  
6 Q07812  
7 P55957  
8 5MES   5MES  
9 Q07820   Q07820  
10 Q07820   6STJ  
11 Q07820   Q07820   Q07820  
12 Q07820   Q07820   Q07820   Q07820  
13 Q07820   6STJ   6STJ   6STJ  
14 Q07820   Q07820   Q07820   Q07820   Q07820  
15 Q07820   Q07820   6STJ   6STJ   6STJ  

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Only interaction residues
#binding
partners
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   EDDLYRQSLE   IISRYLREQA   TGSKDSKPLG   EAGAAGRRAL   ETLRRVGDGV   50
51   QRNHETAFQG   XLRKLDIKNE   DDVKSLSRVX   IHVFSDGVTN   WGRIVTLISF   100
101   GAFVAKHLKT   INQESCIEPL   AESITDVLVR   TKRDWLVKQR   GWDGFVEFFH   150
151   VEDLEGG           200

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
172_ASP GLU 8.3kJPN
chr1:150551491
-
- 0.0001 - -
184_ARG TRP 8.3kJPN
chr1:150551457
-
- 0.0001 - -
192_GLY SER 8.3kJPN
chr1:150551433
rs1047911810
- 0.0002 - -
214_ARG GLY 8.3kJPN
chr1:150551367
-
- 0.0001 - -
227_ALA VAL gnomAD
chr1:150551327
rs11580946
- 0.00842152 - -
267_LEU PHE 8.3kJPN
chr1:150550857
-
- 0.0003 - -
299_VAL LEU gnomAD
chr1:150550761
rs150698207
- 0.000262448 - -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.