PiSITE

PDB ID	2N6A	CHAIN	A
Protein name	human calmodulin/connexin-36 peptide hybrid
Uniprot Accession	P62158
The number of similar proteins	282
The number of binding states	45
The number of binding partners	36

Binding state	Binding partners
	2N6A (CHAIN: A)
1	Monomeric state
2	P62204
3	Q14524
4	P19634
5	Q9H2S1
6	2WEL
7	P40136
8	Q13933
9	P11716
10	Q13813
11	Q62768
12	Q59H93
13	P78352
14	Q7ZJG2
15	Q9H095
16	P34947
17	O00418
18	P35228
19	Q13936
20	O35433
21	O00159
22	Q99250
23	O43525
24	Q5ZTK6
25	Q92736
26	R4X5L7
27	P56696
28	P97479
29	Q9NQA5
30	Q9LF79
31	P62158 Q13936
32	Q13936 Q13936
33	P62155 Q9WTI7
34	P19634 P19634
35	2BKI Q29122
36	Q14524 Q92913
37	P51787 P51787
38	Q96PH1 Q96PH1
39	P62204 Q99104
40	Q6DN90 Q6DN90
41	P62152 Q29122
42	P62203 P62203
43	P62158 Q13936 Q13936
44	P62155 P62155 Q9WTI7
45	P62161 P70604 P70604

Molecule viewer

Only interaction residues

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Sequence information

1

HHHHHHTEEQ

IAEFKEAFSL

FDKDGDGTIT

TKELGTVMRS

LGQNPTEAEL

50

51

QDMINEVDAD

GNGTIDFPEF

LTMMARKMKD

TDSEEEIREA

FRVFDKDGNG

100

101

YISAAELRHV

MTNLGEKLTD

EEVDEMIREA

DIDGDGQVNY

EEFVQMMTGA

150

151

STAAGSGWRK

IKLAVRGAQA

KRK

200

Binding partner information

P62204

Calmodulin

Binding partner information

Q14524

Sodium channel protein type 5 subunit alpha

Binding partner information

P19634

SODIUM/HYDROGEN EXCHANGER 1

Binding partner information

Q9H2S1

Small conductance calcium-activated potassium channel protein 2

Binding partner information

2WEL

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN

Binding partner information

P40136

Calmodulin-sensitive adenylate cyclase

Binding partner information

Q13933

Voltage-dependent L-type calcium channel alpha-1C subunit

Binding partner information

P11716

Ryanodine receptor 1

Binding partner information

Q13813

alpha-II spectrin Spectrin

Binding partner information

Q62768

Protein unc-13 homolog A

Binding partner information

Q59H93

Voltage-gated sodium channel type V alpha isoform b variant

Binding partner information

P78352

Disks large homolog 4

Binding partner information

Q7ZJG2

MA8-43

Binding partner information

Q9H095

IQ domain-containing protein G

Binding partner information

P34947

G protein-coupled receptor kinase 5

Binding partner information

O00418

Eukaryotic elongation factor 2 kinase,Eukaryotic elongation factor 2 kinase

Binding partner information

P35228

Nitric oxide synthase, inducible

Binding partner information

Q13936

Voltage-dependent L-type calcium channel subunit alpha-1C

Binding partner information

O35433

Transient receptor potential cation channel subfamily V member 1

Binding partner information

O00159

UNCONVENTIONAL MYOSIN-IC

Binding partner information

Q99250

Sodium channel protein type 2 subunit alpha

Binding partner information

O43525

Potassium voltage-gated channel subfamily KQT member 3,Potassium voltage-gated channel subfamily KQT member 2

Binding partner information

Q5ZTK6

SidJ

Binding partner information

Q92736

Ryanodine receptor 2

Binding partner information

R4X5L7

OspC3

Binding partner information

P56696

Potassium voltage-gated channel subfamily KQT member 4

Binding partner information

P97479

Unconventional myosin-VIIa

Binding partner information

Q9NQA5

Transient receptor potential cation channel subfamily V member 5

Binding partner information

Q9LF79

CALCIUM-TRANSPORTING ATPASE 8, PLASMA MEMBRANE-TYPE

Binding partner information

	P62158	Calmodulin
	Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C

Binding partner information

	Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C
	Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C

Binding partner information

	P62155	Calmodulin
	Q9WTI7	Unconventional myosin-Ic

Binding partner information

	P19634	Sodium/hydrogen exchanger 1
	P19634	Sodium/hydrogen exchanger 1

Binding partner information

	2BKI	CALMODULIN
	Q29122	UNCONVENTIONAL MYOSIN

Binding partner information

	Q14524	Sodium channel protein type 5 subunit alpha
	Q92913	Fibroblast growth factor 13

Binding partner information

	P51787	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1
	P51787	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1

Binding partner information

	Q96PH1	NADPH oxidase 5
	Q96PH1	NADPH oxidase 5

Binding partner information

	P62204	CALMODULIN
	Q99104	MYOSIN-5A

Binding partner information

	Q6DN90	IQ motif and SEC7 domain-containing protein 1
	Q6DN90	IQ motif and SEC7 domain-containing protein 1

Binding partner information

	P62152	Calmodulin
	Q29122	Myosin-VI

Binding partner information

	P62203	Calmodulin
	P62203	Calmodulin

Binding partner information

	P62158	Calmodulin
	Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C
	Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C

Binding partner information

	P62155	Calmodulin
	P62155	Calmodulin
	Q9WTI7	Unconventional myosin-Ic

Binding partner information

	P62161	Calmodulin
	P70604	Small conductance calcium-activated potassium channel protein 2
	P70604	Small conductance calcium-activated potassium channel protein 2

Variants

Residue	AA	Source	dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	Disease name
23_GLY	GLU	8.3kJPN chr10:5567119	-	-	0.0001	-
29_THR	PRO	ClinVar chr14:90867656	rs1057521851	Likely pathogenic	-	not provided [MedGen:CN517202]
29_THR	SER	8.3kJPN chr10:5567136	-	-	0.0001	-
31_GLU	GLN	gnomAD chr10:5567142	rs2231420	-	0.00532811	-
31_GLU	GLN	8.3kJPN chr10:5567142	rs2231420	-	0.0341	-
51_MET	VAL	8.3kJPN chr10:5567202	-	-	0.0001	-
53_ASN	ILE	ClinVar chr14:90867729	rs267607276	Likely pathogenic	-	Catecholaminergic polymorphic ventricular tachycardia 4\|Catecholaminergic polymorphic ventricular tachycardia 1 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286\|MONDO:MONDO:0011484,MedGen:C1631597,OMIM:604772,Orphanet:3286]
61_GLY	SER	gnomAD chr10:5567232	rs550418190	-	0.000502304	-
66_PRO	SER	gnomAD chr10:5567247	rs75808734	-	0.000394542	-
89_PHE	LEU	ClinVar chr14:90870295	rs730882253	Likely pathogenic	-	Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]
89_PHE	LEU	ClinVar chr2:47389442	-	Likely pathogenic	-	Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
90_ARG	HIS	8.3kJPN chr10:5567320	rs776439000	-	0.0019	-
93_ASP	ALA	ClinVar chr19:47111841	rs1060502608	Pathogenic	-	Long QT syndrome 1\|not provided [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768\|MedGen:C3661900]
95_ASP	VAL	ClinVar chr2:47388996	rs730882254	Pathogenic	-	Long QT syndrome 15\|not provided\|Long QT syndrome 1 [MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768\|MedGen:C3661900\|MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
95_ASP	HIS	ClinVar chr19:47112103	rs1060502607	Pathogenic	-	Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
95_ASP	TYR	ClinVar chr2:47388997	rs1573214371	Pathogenic	-	Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
95_ASP	TYR	ClinVar chr14:90870723	-	Pathogenic	-	Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]; Catecholaminergic polymorphic ventricular tachycardia 4 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286]
96_GLY	SER	8.3kJPN chr10:5567337	rs190000968	-	0.0002	-
97_ASN	SER	ClinVar chr14:90870730	rs267607277	Pathogenic/Likely pathogenic	-	Catecholaminergic polymorphic ventricular tachycardia 4\|Catecholaminergic polymorphic ventricular tachycardia 1\|Long QT syndrome 14 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286\|MONDO:MONDO:0011484,MedGen:C1631597,OMIM:604772,Orphanet:3286\|MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]; Catecholaminergic polymorphic ventricular tachycardia 4\|Catecholaminergic polymorphic ventricular tachycardia\|Cardiovascular phenotype [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286\|MONDO:MONDO:0017990,MedGen:C5574922,OMIM:PS604772,Orphanet:3286\|MedGen:CN230736]
97_ASN	SER	ClinVar chr2:47388990	rs398124647	Pathogenic	-	Long QT syndrome 1\|Long QT syndrome 15\|Long QT syndrome [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768\|MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768\|MONDO:MONDO:0002442,MeSH:D008133,MedGen:C0023976]
97_ASN	ILE	ClinVar chr2:47388990	rs398124647	Pathogenic	-	Long QT syndrome 1\|Long QT syndrome 15 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768\|MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768]
104_GLU	LYS	ClinVar chr14:90870750	rs1057523130	Likely pathogenic	-	not provided [MedGen:CN517202]
104_GLU	GLN	ClinVar chr2:47388970	-	Likely pathogenic	-	Long QT syndrome 15 [MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768]
113_GLY	ARG	ClinVar chr2:47388943	rs2103823712	Pathogenic	-	SUDDEN INFANT DEATH SYNDROME [EFO:EFO_0005303,MeSH:D013398,MedGen:C0038644,OMIM:272120]
120_GLU	LYS	8.3kJPN chr10:5567409	-	-	0.0001	-
126_ARG	TRP	gnomAD chr10:5567427	rs754327442	-	0.000119868	-
128_ALA	VAL	8.3kJPN chr10:5567434	rs752809700	-	0.0002	-
129_ASP	GLY	ClinVar chr14:90870826	rs730882252	Pathogenic/Likely pathogenic	-	Long QT syndrome 14\|not provided [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768\|MedGen:C3661900]
129_ASP	GLY	ClinVar chr19:47112206	rs1599759554	Pathogenic	-	Long QT syndrome 16 [MONDO:MONDO:0032915,MedGen:C5394068,OMIM:618782]
129_ASP	GLY	ClinVar chr2:47388894	rs1573214163	Likely pathogenic	-	Long QT syndrome 15\|Long QT syndrome 1 [MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768\|MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
129_ASP	ASN	ClinVar chr2:47388895	rs2103823638	Pathogenic	-	Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
129_ASP	GLU	ClinVar chr19:47112207	rs35617141	Pathogenic	-	Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
129_ASP	ASN	8.3kJPN chr10:5567436	rs777995357	-	0.0002	-
129_ASP	GLU	8.3kJPN chr10:5567438	rs751753306	-	0.0002	-
130_THR	ARG	8.3kJPN chr10:5567440	-	-	0.0001	-
131_ASP	GLU	ClinVar chr2:47388887	rs398124648	Pathogenic	-	Long QT syndrome 15\|Long QT syndrome 1 [MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768\|MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
131_ASP	GLY	ClinVar chr19:47112212	rs1057523474	Likely pathogenic	-	not provided [MedGen:CN517202]
131_ASP	GLU	ClinVar chr19:47112213	rs1064796271	Pathogenic	-	not provided [MedGen:CN517202]
131_ASP	ASN	ClinVar chr14:90870831	rs1595102640	Pathogenic	-	Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]; Catecholaminergic polymorphic ventricular tachycardia 4 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286]
131_ASP	VAL	ClinVar chr14:90870832	rs1887113791	Pathogenic	-	Catecholaminergic polymorphic ventricular tachycardia 4 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286]; Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]
131_ASP	GLY	ClinVar chr2:47388888	rs1687164164	Pathogenic	-	Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
131_ASP	GLY	ClinVar chr14:90870832	rs1887113791	Pathogenic	-	Catecholaminergic polymorphic ventricular tachycardia 4 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286]; Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]
131_ASP	TYR	ClinVar chr2:47388889	rs2103823612	Pathogenic	-	Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
132_GLY	GLU	ClinVar chr14:90870835	rs1555366045	Likely pathogenic	-	Catecholaminergic polymorphic ventricular tachycardia 4 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286]; Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]
132_GLY	SER	ClinVar chr2:47388886	rs2103823599	Likely pathogenic	-	Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
133_ASP	HIS	ClinVar chr2:47388883	rs398124650	Pathogenic/Likely pathogenic	-	Long QT syndrome 1\|Long QT syndrome 15 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768\|MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768]
135_GLN	PRO	ClinVar chr2:47388876	rs398124649	Pathogenic/Likely pathogenic	-	Long QT syndrome 1\|Long QT syndrome 15 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768\|MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768]
137_ASN	LYS	ClinVar chr2:47388869	rs1553431702	Pathogenic	-	Long QT syndrome 15 [MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768]
139_GLU	VAL	ClinVar chr14:90870856	rs1064793078	Likely pathogenic	-	not provided [MedGen:CN517202]
140_GLU	GLY	ClinVar chr19:47112382	rs1555814427	Likely pathogenic	-	Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
140_GLU	LYS	ClinVar chr19:47112238	rs1599759598	Pathogenic	-	Long QT syndrome 16\|Long QT syndrome 1 [MONDO:MONDO:0032915,MedGen:C5394068,OMIM:618782\|MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
140_GLU	GLY	ClinVar chr14:90871033	rs1887120112	Pathogenic	-	Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]
140_GLU	VAL	ClinVar chr14:90871033	rs1887120112	Pathogenic	-	Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]
140_GLU	ASP	ClinVar chr2:47387942	rs2103821507	Likely pathogenic	-	Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
141_PHE	LEU	ClinVar chr14:90871037	rs199744595	Pathogenic	-	Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]
141_PHE	LEU	ClinVar chr14:90871035	rs1085307479	Pathogenic	-	not provided\|Long QT syndrome 14 [MedGen:C3661900\|MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]; Catecholaminergic polymorphic ventricular tachycardia 4 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286]
141_PHE	LEU	ClinVar chr14:90871037	rs199744595	Pathogenic	-	Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]; Catecholaminergic polymorphic ventricular tachycardia 4 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286]
144_MET	ARG	ClinVar chr2:47387931	rs1558693760	Likely pathogenic	-	Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
144_VAL	MET	gnomAD chr10:5567481	rs530831313	-	0.000136752	-
157_ARG	HIS	8.3kJPN chr15:35044812	rs376923298	-	0.0001	-
164_ARG	GLN	gnomAD chr15:35044791	rs777460358	-	0.00012724	-

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Variants

Reference