PDB ID 2LZG     CHAIN A
Protein name E3 ubiquitin-protein ligase Mdm2
Uniprot Accession Q00987
The number of similar proteins 42
The number of binding states 7
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2LZG (CHAIN: A)
1 Monomeric state
2 Q00987  
3 P36649  
4 5WTS  
5 2M86  
6 Q328D2  
7 Q00987   5SWK  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MCNTNMSVPT   DGAVTTSQIP   ASEQETLVRP   KPLLLKLLKS   VGAQKDTYTM   50
51   KEVLFYLGQY   IMTKRLYDEK   QQHIVYCSND   LLGDLFGVPS   FSVKEHRKIY   100
101   TMIYRNLVVV   NQQESSDSGT   SVSEN       150

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
5_ASN SER 8.3kJPN
chr12:69203005
-
- 0.0001 0.0628 -
9_PRO LEU gnomAD
chr12:69203017
rs201821879
- 0.000160289 0.0939 -
10_THR ILE 8.3kJPN
chr12:69203020
-
- 0.0001 0.156 -
38_LEU VAL 8.3kJPN
chr12:69207364
-
- 0.0001 0.8523 -
120_THR ILE 8.3kJPN
chr12:69218161
rs1320937462
- 0.0001 0.0866 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.