| PDB ID | 2JJV
|
CHAIN | A |
|---|---|---|---|
| Protein name | SIGNAL-REGULATORY PROTEIN BETA 1. | ||
| Uniprot Accession | Q5TFQ8 | ||
| The number of similar proteins | 17 | ||
| The number of binding states | 5 | ||
| The number of binding partners | 4 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 2JJV (CHAIN: A) | |
| 1 | Monomeric state |
| 2 |
Q08722
|
| 3 |
P78324
|
| 4 |
6NMR
6NMR
|
| 5 |
6NMS
6NMS
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 13_ILE | VAL |
gnomAD chr20:1592312 rs72484087 |
- | 0.376733 | - | - | |
| 13_ILE | VAL |
8.3kJPN chr20:1592312 rs72484087 |
- | 0.6712 | - | - | |
| 14_LEU | SER |
gnomAD chr20:1895796 rs143735290 |
- | 0.0599336 | - | - | |
| 14_LEU | SER |
8.3kJPN chr20:1895796 rs143735290 |
- | 0.6253 | - | - | |
| 20_THR | SER |
gnomAD chr20:1895813 rs17855609 |
- | 0.0448665 | - | - | |
| 20_SER | TRP |
8.3kJPN chr20:1559271 rs200657161 |
- | 0.0011 | - | - | |
| 20_THR | SER |
8.3kJPN chr20:1895813 rs17855609 |
- | 0.6261 | - | - | |
| 22_THR | ILE |
VAR_059411
rs1135196 |
LB/B | - | - | - | |
| 22_THR | ILE |
gnomAD chr20:1592284 rs1135196 |
- | 0.463184 | - | - | |
| 22_THR | ILE |
gnomAD chr20:1895820 rs17855610 |
- | 0.0628446 | - | - | |
| 22_THR | ILE |
8.3kJPN chr20:1592284 rs1135196 |
- | - | - | - | |
| 22_THR | ILE |
8.3kJPN chr20:1895820 rs17855610 |
- | - | - | - | |
| 24_ARG | HIS |
gnomAD chr20:1559259 rs2746603 |
- | 0.0699548 | - | - | |
| 24_ARG | CYS |
gnomAD chr20:1559260 rs143134459 |
- | 0.000197796 | - | - | |
| 24_ARG | HIS |
gnomAD chr20:1895826 rs17855611 |
- | 0.0701003 | - | - | |
| 24_ARG | HIS |
8.3kJPN chr20:1559259 rs2746603 |
- | 0.0001 | - | - | |
| 24_ARG | CYS |
8.3kJPN chr20:1895825 rs758642581 |
- | 0.0001 | - | - | |
| 24_ARG | HIS |
8.3kJPN chr20:1895826 rs17855611 |
- | 0.6265 | - | - | |
| 26_THR | ILE |
gnomAD chr20:1629967 rs143978848 |
- | 0.000298325 | - | - | |
| 27_ALA | VAL |
gnomAD chr20:1895835 rs17855612 |
- | 0.0780698 | - | - | |
| 27_ALA | VAL |
8.3kJPN chr20:1895835 rs17855612 |
- | 0.6275 | - | - | |
| 31_ILE | VAL |
8.3kJPN chr20:1592258 - |
- | 0.0001 | - | - | |
| 32_PRO | ALA |
gnomAD chr20:1592255 rs191373314 |
- | 0.000897313 | - | - | |
| 33_VAL | LEU |
gnomAD chr20:1559233 rs41275424 |
- | 0.00880613 | - | - | |
| 33_VAL | MET |
8.3kJPN chr20:1629947 rs138452343 |
- | 0.0001 | - | - | |
| 35_PRO | ALA |
8.3kJPN chr20:1629941 rs200917950 |
- | 0.0004 | - | - | |
| 36_VAL | ILE |
gnomAD chr20:1629938 rs62641738 |
- | 0.000214761 | - | - | |
| 36_VAL | ILE |
8.3kJPN chr20:1629938 rs62641738 |
- | 0.0002 | - | - | |
| 38_TRP | LEU |
gnomAD chr20:1629931 rs143474967 |
- | 0.000266467 | - | - | |
| 42_ALA | GLY |
8.3kJPN chr20:1895880 rs143351148 |
- | 0.0001 | - | - | |
| 43_GLY | ALA |
8.3kJPN chr20:1559202 rs762669905 |
- | 0.0005 | - | - | |
| 45_GLY | ALA |
gnomAD chr20:1592215 rs41289057 |
- | 0.26699 | - | - | |
| 45_GLY | ALA |
gnomAD chr20:1895889 rs1057114 |
- | 0.347307 | - | - | |
| 45_GLY | ALA |
8.3kJPN chr20:1592215 rs41289057 |
- | 0.6674 | - | - | |
| 45_GLY | ALA |
8.3kJPN chr20:1895889 rs1057114 |
- | 0.6349 | - | - | |
| 47_GLU | ASP |
8.3kJPN chr20:1592208 - |
- | 0.0001 | - | - | |
| 49_ILE | PHE |
gnomAD chr20:1559185 rs145222149 |
- | 0.000843225 | - | - | |
| 59_ARG | TRP |
gnomAD chr20:1559155 rs62641724 |
- | 0.000415534 | - | - | |
| 59_ARG | TRP |
gnomAD chr20:1592174 rs755774584 |
- | 0.000206136 | - | - | |
| 59_ARG | TRP |
8.3kJPN chr20:1592174 rs755774584 |
- | 0.0001 | - | - | |
| 61_THR | LYS |
8.3kJPN chr20:1629862 - |
- | 0.0001 | - | - | |
| 65_GLU | ASP |
gnomAD chr20:1559135 rs145689140 |
- | 0.00263842 | - | - | |
| 65_ASP | GLU |
gnomAD chr20:1592154 rs200203262 |
- | 0.000101353 | - | - | |
| 65_GLU | ASP |
8.3kJPN chr20:1559135 rs145689140 |
- | 0.0001 | - | - | |
| 65_ASP | GLU |
8.3kJPN chr20:1592154 rs200203262 |
- | 0.0018 | - | - | |
| 65_ASP | VAL |
8.3kJPN chr20:1592155 rs759284621 |
- | 0.0006 | - | - | |
| 66_LEU | PRO |
8.3kJPN chr20:1592152 rs201646968 |
- | 0.0014 | - | - | |
| 70_ASN | LYS |
gnomAD chr20:1592139 rs149722469 |
- | 0.105474 | - | - | |
| 70_ASN | ASP |
gnomAD chr20:1592141 rs141518677 |
- | 0.103716 | - | - | |
| 70_ASN | ASP |
gnomAD chr20:1895963 rs17855613 |
- | 0.303015 | - | - | |
| 70_ASN | LYS |
gnomAD chr20:1895965 rs17855614 |
- | 0.29706 | - | - | |
| 70_ASN | LYS |
8.3kJPN chr20:1592139 rs149722469 |
- | 0.3875 | - | - | |
| 70_ASN | ASP |
8.3kJPN chr20:1592141 rs141518677 |
- | 0.3878 | - | - | |
| 70_ASN | ASP |
8.3kJPN chr20:1895963 rs17855613 |
- | 0.6403 | - | - | |
| 70_ASN | LYS |
8.3kJPN chr20:1895965 rs17855614 |
- | 0.6403 | - | - | |
| 77_SER | ARG |
gnomAD chr20:1559101 rs41275422 |
- | 0.235934 | - | - | |
| 77_ARG | SER |
gnomAD chr20:1592120 rs1135201 |
- | 0.100228 | - | - | |
| 77_ARG | SER |
gnomAD chr20:1895984 rs17855615 |
- | 0.313565 | - | - | |
| 77_SER | ARG |
8.3kJPN chr20:1559101 rs41275422 |
- | 0.5501 | - | - | |
| 77_ARG | SER |
8.3kJPN chr20:1592120 rs1135201 |
- | 0.4104 | - | - | |
| 77_ARG | SER |
8.3kJPN chr20:1895984 rs17855615 |
- | 0.6404 | - | - | |
| 79_SER | GLY |
gnomAD chr20:1592114 rs1135202 |
- | 0.000703169 | - | - | |
| 79_GLY | SER |
gnomAD chr20:1895990 rs17855616 |
- | 0.318946 | - | - | |
| 79_SER | GLY |
8.3kJPN chr20:1592114 rs1135202 |
- | 0.0004 | - | - | |
| 79_GLY | SER |
8.3kJPN chr20:1895990 rs17855616 |
- | 0.6496 | - | - | |
| 80_SER | ASN |
gnomAD chr20:1629805 rs62641735 |
- | 0.00109359 | - | - | |
| 81_ILE | VAL |
8.3kJPN chr20:1895996 - |
- | 0.0001 | - | - | |
| 82_THR | ILE |
8.3kJPN chr20:1629799 - |
- | 0.0001 | - | - | |
| 83_PRO | SER |
8.3kJPN chr20:1592102 - |
- | 0.0001 | - | - | |
| 83_PRO | SER |
8.3kJPN chr20:1896002 - |
- | 0.0001 | - | - | |
| 87_GLY | SER |
8.3kJPN chr20:1896014 rs377556462 |
- | 0.0001 | - | - | |
| 95_ARG | GLN |
gnomAD chr20:1559046 rs145977289 |
- | 0.00026655 | - | - | |
| 95_ARG | GLN |
8.3kJPN chr20:1559046 rs145977289 |
- | 0.0001 | - | - | |
| 95_ARG | GLN |
8.3kJPN chr20:1896039 rs767136065 |
- | 0.0001 | - | - | |
| 100_ASP | GLU |
8.3kJPN chr20:1559030 - |
- | 0.0002 | - | - | |
| 100_ASP | ASN |
8.3kJPN chr20:1592051 - |
- | 0.0009 | - | - | |
| 101_HIS | ASP |
gnomAD chr20:1592048 rs45545343 |
- | 0.00284327 | - | - | |
| 102_VAL | MET |
gnomAD chr20:1896059 rs115287948 |
- | 0.286949 | - | - | |
| 102_VAL | ALA |
gnomAD chr20:1896060 rs114499682 |
- | 0.292307 | - | - | |
| 102_VAL | MET |
8.3kJPN chr20:1896059 rs115287948 |
- | 0.6411 | - | - | |
| 102_VAL | ALA |
8.3kJPN chr20:1896060 rs114499682 |
- | 0.6411 | - | - | |
| 115_ARG | CYS |
gnomAD chr20:1558987 rs368470461 |
- | 0.000125293 | - | - | |
| 115_ARG | HIS |
8.3kJPN chr20:1558986 rs201638914 |
- | 0.0002 | - | - | |
| 115_GLY | VAL |
8.3kJPN chr20:1629700 - |
- | 0.0001 | - | - |