PDB ID 2HXY     CHAIN A
Protein name Probable ATP-dependent RNA helicase DDX48
Uniprot Accession P38919
The number of similar proteins 8
The number of binding states 5
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2HXY (CHAIN: A)
1 Monomeric state
2 Q9HCG8  
3 O15234  
4 O15234   Q9Y5S9   P61326  
5 O15234   Q9Y5S9   P61326   Q9BZI7  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   MTKVEFETSE   EVDVTPTFDT   MGLREDLLRG   IYAYGFEKPS   AIQQRAIKQI   50
51   IKGRDVIAQS   QSGTGKTATF   SISVLQCLDI   QVRETQALIL   APTRELAVQI   100
101   QKGLLALGDY   MNVQCHACIG   GTNVGEDIRK   LDYGQHVVAG   TPGRVFDMIR   150
151   RRSLRTRAIK   MLVLDEADEM   LNKGFKEQIY   DVYRYLPPAT   QVVLISATLP   200
201   HEILEMTNKF   MTDPIRILVK   RDELTLEGIK   QFFVAVEREE   WKFDTLCDLY   250
251   DTLTITQAVI   FCNTKRKVDW   LTEKMREANF   TVSSMHGDMP   QKERESIMKE   300
301   FRSGASRVLI   STDVWARGLD   VPQVSLIINY   DLPNNRELYI   HRIGRSGRYG   350
351   RKGVAINFVK   NDDIRILRDI   EQYYSTQIDE   MPMNVADLIL   E   400

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
73_ILE LEU 8.3kJPN
chr17:78117996
-
- 0.0001 0.1489 -
270_ASP GLY VAR_071090
rs587777204
LP/P - 0.9976 Richieri-Costa-Pereira syndrome (RCPS) [MIM:268305]
270_ASP GLY ClinVar
chr17:78111999
rs587777204
Pathogenic - 0.9976 Richieri Costa-Pereira syndrome [MONDO:MONDO:0009998,MedGen:C1849348,OMIM:268305,Orphanet:3102]
327_ALA THR 8.3kJPN
chr17:78111189
rs757676343
- 0.0001 0.1008 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.