PDB ID 2HAU     CHAIN A
Protein name Serotransferrin
Uniprot Accession P02787
The number of similar proteins 26
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2HAU (CHAIN: A)
1 Monomeric state
2 Q09057  
3 Q9K0U9  
4 P02786  
5 Q8WPU2   Q8WPU1  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   KTVRWCAVSE   HEATKCQSFR   DHXKSVIPSD   GPSVACVKKA   SYLDCIRAIA   50
51   ANEADAVTLD   AGLVYDAYLA   PNNLKPVVAE   FYGSKEDPQT   FYYAVAVVKK   100
101   DSGFQXNQLR   GKKSCHTGLG   RSAGWNIPIG   LLYCDLPEPR   KPLEKAVANF   150
151   FSGSCAPCAD   GTDFPQLCQL   CPGCGCSTLN   QYFGYSGAFK   CLKDGAGDVA   200
201   FVKHSTIFEN   LANKADRDQY   ELLCLDNTRK   PVDEYKDCHL   AQVPSHTVVA   250
251   RSXGGKEDLI   WELLNQAQEH   FGKDKSKEFQ   LFSSPHGKDL   LFKDSAHGFL   300
301   KVPPRXDAKX   YLGYEYVTAI   RNLREGTCPE   APTDECKPVK   WCALSHHERL   350
351   KCDEWSVNSV   GKIECVSAET   TEDCIAKIXN   GEADAXSLDG   GFVYIAGKCG   400
401   LVPVLAENYD   KSDNCEDTPE   AGYFAVAVVK   KSASDLTWDN   LKGKKSCHTA   450
451   VGRTAGWNIP   XGLLYNKINH   CRFDEFFSEG   CAPGSKKDSS   LCKLCXGSGL   500
501   NLCEPNNKEG   YYGYTGAFRC   LVEKGDVAFV   KHQTVPQNTG   GKNPDPWAKN   550
551   LNEKDYELLC   LDGTRKPVEE   YANCHLARAP   NHAVVTRKDK   EACVHKILRQ   600
601   QQHLFGSDVT   DCSGNFCLFR   SETKDLLFRD   DTVCLAKLHD   RNTYEKYLGE   650
651   EYVKAVGNLR   KCSTSSLLEA   CTFRRP       700

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
21_SER ASN gnomAD
chr3:133467331 		rs146477698
- 0.000373805 -
23_ARG LEU VAR_034569 rs41298293
LB/B - -
23_ARG LEU gnomAD
chr3:133467337 		rs41298293
- 0.00276379 -
36_SER ARG VAR_029280 rs8177318
LB/B - -
36_SER ARG gnomAD
chr3:133467377 		rs8177318
- 0.000163054 -
57_ALA VAL VAR_034570 rs41298977
LB/B - -
57_ALA VAL gnomAD
chr3:133472449 		rs41298977
- 0.000433427 -
57_ALA VAL 8.3kJPN
chr3:133472449 		rs41298977
- 0.0041 -
58_ASP ASN VAR_038810 rs121918681
LP/P - Atransferrinemia (ATRAF) [MIM:209300]
58_ASP ASN ClinVar
chr3:133472451 		rs121918681
Pathogenic - Atransferrinemia [Human Phenotype Ontology:HP:0012239,MONDO:MONDO:0008846,MedGen:C0521802,OMIM:209300,Orphanet:1195]
75_ASN SER gnomAD
chr3:133472503 		rs200551981
- 0.000441362 -
85_TYR CYS 8.3kJPN
chr3:133472533 		rs746672239
- 0.001 -
123_GLY SER VAR_011997 rs1799830
LB/B - -
152_ASN SER 8.3kJPN
chr3:133474216 		-
- 0.0001 -
155_SER LEU gnomAD
chr3:133474225 		rs150679929
- 0.000774926 -
155_SER LEU 8.3kJPN
chr3:133474225 		rs150679929
- 0.0016 -
159_ALA VAL 8.3kJPN
chr3:133474237 		rs752884982
- 0.0001 -
165_THR ALA gnomAD
chr3:133474254 		rs139768770
- 0.00010439 -
200_GLY ARG 8.3kJPN
chr3:133475145 		-
- 0.0001 -
232_ARG GLN 8.3kJPN
chr3:133475735 		rs972941728
- 0.0001 -
258_GLY SER VAR_011998 rs1799899
LB/B - -
258_GLY ASP ClinVar
chr3:133475813 		rs121918676
Pathogenic - - [-]
258_GLY SER gnomAD
chr3:133475812 		rs1799899
- 0.0523667 -
277_ASP GLY VAR_007544 rs8177238
LB/B - -
277_ASP GLY gnomAD
chr3:133476629 		rs8177238
- 0.00288353 -
300_HIS ARG VAR_007545 rs41295774
LB/B - -
300_HIS ARG gnomAD
chr3:133476698 		rs41295774
- 0.00328851 -
300_HIS ARG 8.3kJPN
chr3:133476698 		rs41295774
- 0.0064 -
324_ARG TRP gnomAD
chr3:133476769 		rs150854910
- 0.000843358 -
327_ARG TRP 8.3kJPN
chr3:133476778 		rs143019827
- 0.0017 -
327_ARG GLN 8.3kJPN
chr3:133476779 		rs773827823
- 0.0005 -
336_THR LYS 8.3kJPN
chr3:133478034 		rs773883338
- 0.0001 -
350_HIS ARG 8.3kJPN
chr3:133478076 		-
- 0.0001 -
358_TRP CYS VAR_011999 rs1804498
LB/B - -
368_CYS TYR 8.3kJPN
chr3:133478130 		rs1299270179
- 0.0001 -
379_ALA THR 8.3kJPN
chr3:133478162 		rs761574297
- 0.0001 -
396_VAL ILE 8.3kJPN
chr3:133483065 		-
- 0.0001 -
416_ASP ASN 8.3kJPN
chr3:133483724 		rs201067725
- 0.0001 -
429_VAL ILE VAR_058199 rs2692696
LB/B - -
429_ILE VAL gnomAD
chr3:133485133 		rs2692696
- 0.99126 -
430_ALA THR 8.3kJPN
chr3:133485136 		-
- 0.0001 -
445_LYS ARG 8.3kJPN
chr3:133485182 		rs753390506
- 0.0001 -
458_ALA PRO VAR_012997 rs121918679
LP/P - Atransferrinemia (ATRAF) [MIM:209300]
458_ALA PRO ClinVar
chr3:133485220 		rs121918679
Pathogenic - Atransferrinemia [Human Phenotype Ontology:HP:0012239,MONDO:MONDO:0008846,MedGen:C0521802,OMIM:209300,Orphanet:1195]
463_PRO SER ClinVar
chr3:133485235 		rs2107925842
Likely pathogenic - Atransferrinemia [Human Phenotype Ontology:HP:0012239,MONDO:MONDO:0008846,MedGen:C0521802,OMIM:209300,Orphanet:1195]
467_LEU PHE 8.3kJPN
chr3:133485247 		rs771354238
- 0.0001 -
496_LYS THR 8.3kJPN
chr3:133486930 		-
- 0.0001 -
516_GLY SER 8.3kJPN
chr3:133486989 		rs752715864
- 0.0001 -
520_ALA THR gnomAD
chr3:133487001 		rs369813809
- 0.000159103 -
543_GLY VAL VAR_034571 rs41296590
LB/B - -
570_PRO SER VAR_012000 rs1049296
LB/B - -
570_PRO SER gnomAD
chr3:133494354 		rs1049296
- 0.160287 -
570_PRO SER 8.3kJPN
chr3:133494354 		rs1049296
- 0.2232 -
590_ARG TRP ClinVar
chr3:133494414 		rs773139494
Likely pathogenic - Atransferrinemia [Human Phenotype Ontology:HP:0012239,MONDO:MONDO:0008846,MedGen:C0521802,OMIM:209300,Orphanet:1195]
592_ASP TYR 8.3kJPN
chr3:133494420 		-
- 0.0004 -
616_SER LEU gnomAD
chr3:133495924 		rs199594823
- 0.000497093 -
626_THR PRO VAR_012001 rs1130537
LB/B - -
627_LYS GLU VAR_012998 rs121918678
LB/B - -
627_LYS GLU ClinVar
chr3:133495956 		rs121918678
Pathogenic - - [-]
634_ASP GLY 8.3kJPN
chr3:133495978 		-
- 0.0001 -
652_GLY GLU VAR_012999 rs121918677
LB/B - -
652_GLY GLU gnomAD
chr3:133496032 		rs121918677
- 0.0025076 -
673_ALA VAL 8.3kJPN
chr3:133497442 		rs1032981099
- 0.0001 -
677_ARG HIS 8.3kJPN
chr3:133497454 		rs57329669
- 0.0001 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.