PDB ID 2F9L     CHAIN A
Protein name RAB11B, member RAS oncogene family
Uniprot Accession Q15907
The number of similar proteins 35
The number of binding states 12
The number of binding partners 8

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2F9L (CHAIN: A)
1 Monomeric state
2 Q64595  
3 Q9UBF8  
4 O60239  
5 Q96QF0  
6 Q9ULV0  
7 P62491  
8 O75154  
9 O75154  
10 O75154   Q96QF0  
11 Q7L804   Q7L804  
12 O75154   O75154   Q96QF0  

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Molecule viewer


Only interaction residues
#binding
partners
  8
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MYDYLFKVVL   IGDSGVGKSN   LLSRFTRNEF   NLESKSTIGV   EFATRSIQVD   50
51   GKTIKAQIWD   TAGQERYRRI   TSAYYRGAVG   ALLVYDIAKH   LTYENVERWL   100
101   KELRDHADSN   IVIMLVGNKS   DLRHLRAVPT   DEARAFAEKN   NLSFIETSAL   150
151   DSTNVEEAFK   NILTEIYRIV   SQKQIADRAA   HDESPGNNVV   DISVPPTTD   200

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
22_VAL MET VAR_080598
rs1555690779
LP/P - 0.9973 Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter (NDAGSCW) [MIM:617807]
22_VAL MET ClinVar
chr19:8464770
rs1555690779
Pathogenic/Likely pathogenic - 0.9973 Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter [MONDO:MONDO:0060624,MedGen:C4540498,OMIM:617807]
68_ALA THR VAR_080599
rs1555690804
LP/P - 0.9977 Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter (NDAGSCW) [MIM:617807]
68_ALA THR ClinVar
chr19:8464908
rs1555690804
Pathogenic/Likely pathogenic - 0.9977 Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter|not provided [MONDO:MONDO:0060624,MedGen:C4540498,OMIM:617807|MedGen:C3661900]
102_VAL MET 8.3kJPN
chr19:8467037
rs1437902263
- 0.0001 0.7943 -
110_ARG TRP 8.3kJPN
chr19:8467061
rs776189936
- 0.0013 0.6851 -
112_HIS ARG ClinVar
chr15:66170198
-
Likely pathogenic - 0.9441 7 conditions [7 conditions]
120_MET VAL 8.3kJPN
chr15:66170221
-
- 0.0001 0.6777 -
120_MET ILE 8.3kJPN
chr19:8467093
-
- 0.0001 0.9417 -
154_SER LEU ClinVar
chr15:66172039
-
Pathogenic/Likely pathogenic - 0.9982 not provided [MedGen:C3661900]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.