PDB ID 2EWY     CHAIN A
Protein name Beta-secretase 2
Uniprot Accession Q9Y5Z0
The number of similar proteins 20
The number of binding states 6
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2EWY (CHAIN: A)
1 Monomeric state
2 3ZKQ  
3 3ZL7  
4 3ZKN   3ZKN  
5 3ZKX   3ZKX  
6 Q9Y5Z0   3ZLQ  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   LAMVDNLQGD   SGRGYYLEML   IGTPPQKLQI   LVDTGSSNFA   VAGTPHSYID   50
51   TYFDTERSST   YRSKGFDVTV   KYTQGSWTGF   VGEDLVTIPK   GFNTSFLVNI   100
101   ATIFESENFF   LPGIKWNGIL   GLAYATLAKP   SSSLETFFDS   LVTQANIPNV   150
151   FSMQMCGAGL   PVAGSGTNGG   SLVLGGIEPS   LYKGDIWYTP   IKEEWYYQIE   200
201   ILKLEIGGQS   LNLDCREYNA   DKAIVDSGTT   LLRLPQKVFD   AVVEAVARAS   250
251   LIPEFSDGFW   TGSQLACWTN   SETPWSYFPK   ISIYLRDENS   SRSFRITILP   300
301   QLYIQPMMGA   GLNYECYRFG   ISPSTNALVI   GATVMEGFYV   IFDRAQKRVG   350
351   FAASPCAEIA   GAAVSEISGP   FSTEDVASNC   VPA     400

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
40_PRO SER 8.3kJPN
chr21:42540494 		rs780184860
- 0.0002 -
66_THR ALA 8.3kJPN
chr21:42598262 		-
- 0.0001 -
77_ARG CYS 8.3kJPN
chr21:42609453 		rs766433535
- 0.0001 -
83_VAL ILE 8.3kJPN
chr21:42609471 		rs369116567
- 0.0001 -
96_VAL ILE gnomAD
chr21:42609510 		rs781596817
- 0.000127257 -
96_VAL ILE 8.3kJPN
chr21:42609510 		rs781596817
- 0.0004 -
101_VAL ILE 8.3kJPN
chr21:42609525 		rs778102614
- 0.0001 -
106_GLY VAL 8.3kJPN
chr21:42609541 		-
- 0.0001 -
165_VAL ILE gnomAD
chr21:42613806 		rs139181635
- 0.000123268 -
207_LYS ARG 8.3kJPN
chr21:42615361 		-
- 0.0001 -
252_LYS THR 8.3kJPN
chr21:42617947 		-
- 0.0001 -
256_ALA VAL 8.3kJPN
chr21:42617959 		rs531921336
- 0.0001 -
263_ARG HIS 8.3kJPN
chr21:42617980 		rs375722579
- 0.0001 -
284_THR MET 8.3kJPN
chr21:42622731 		rs1025896897
- 0.0001 -
286_SER LEU 8.3kJPN
chr21:42622737 		rs141768735
- 0.0001 -
289_PRO ARG 8.3kJPN
chr21:42622746 		rs768959890
- 0.0002 -
290_TRP SER 8.3kJPN
chr21:42622749 		rs781629087
- 0.0002 -
310_ARG CYS 8.3kJPN
chr21:42622808 		rs139556900
- 0.0001 -
355_VAL ILE 8.3kJPN
chr21:42629199 		rs146761165
- 0.0001 -
370_PRO LEU 8.3kJPN
chr21:42629245 		rs761187359
- 0.0004 -
371_CYS PHE 8.3kJPN
chr21:42629248 		rs1206170769
- 0.0001 -
385_PRO LEU 8.3kJPN
chr21:42647334 		-
- 0.0001 -
398_ALA THR gnomAD
chr21:42647372 		rs149345353
- 0.00314583 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.