| PDB ID | 2EWY
|
CHAIN | A |
|---|---|---|---|
| Protein name | Beta-secretase 2 | ||
| Uniprot Accession | Q9Y5Z0 | ||
| The number of similar proteins | 20 | ||
| The number of binding states | 6 | ||
| The number of binding partners | 4 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 2EWY (CHAIN: A) | |
| 1 | Monomeric state |
| 2 |
3ZKQ
|
| 3 |
3ZL7
|
| 4 |
3ZKN
3ZKN
|
| 5 |
3ZKX
3ZKX
|
| 6 |
Q9Y5Z0
3ZLQ
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 40_PRO | SER |
8.3kJPN chr21:42540494 rs780184860 |
- | 0.0002 | 0.1504 | - | |
| 66_THR | ALA |
8.3kJPN chr21:42598262 - |
- | 0.0001 | 0.0613 | - | |
| 77_ARG | CYS |
8.3kJPN chr21:42609453 rs766433535 |
- | 0.0001 | 0.1603 | - | |
| 83_VAL | ILE |
8.3kJPN chr21:42609471 rs369116567 |
- | 0.0001 | 0.1164 | - | |
| 96_VAL | ILE |
gnomAD chr21:42609510 rs781596817 |
- | 0.000127257 | 0.0867 | - | |
| 96_VAL | ILE |
8.3kJPN chr21:42609510 rs781596817 |
- | 0.0004 | 0.0867 | - | |
| 101_VAL | ILE |
8.3kJPN chr21:42609525 rs778102614 |
- | 0.0001 | 0.0777 | - | |
| 106_GLY | VAL |
8.3kJPN chr21:42609541 - |
- | 0.0001 | 0.2638 | - | |
| 165_VAL | ILE |
gnomAD chr21:42613806 rs139181635 |
- | 0.000123268 | 0.0568 | - | |
| 207_LYS | ARG |
8.3kJPN chr21:42615361 - |
- | 0.0001 | 0.0791 | - | |
| 252_LYS | THR |
8.3kJPN chr21:42617947 - |
- | 0.0001 | 0.1309 | - | |
| 256_ALA | VAL |
8.3kJPN chr21:42617959 rs531921336 |
- | 0.0001 | 0.1813 | - | |
| 263_ARG | HIS |
8.3kJPN chr21:42617980 rs375722579 |
- | 0.0001 | 0.0734 | - | |
| 284_THR | MET |
8.3kJPN chr21:42622731 rs1025896897 |
- | 0.0001 | 0.0969 | - | |
| 286_SER | LEU |
8.3kJPN chr21:42622737 rs141768735 |
- | 0.0001 | 0.1164 | - | |
| 289_PRO | ARG |
8.3kJPN chr21:42622746 rs768959890 |
- | 0.0002 | 0.8903 | - | |
| 290_TRP | SER |
8.3kJPN chr21:42622749 rs781629087 |
- | 0.0002 | 0.5847 | - | |
| 310_ARG | CYS |
8.3kJPN chr21:42622808 rs139556900 |
- | 0.0001 | 0.1888 | - | |
| 355_VAL | ILE |
8.3kJPN chr21:42629199 rs146761165 |
- | 0.0001 | 0.1239 | - | |
| 370_PRO | LEU |
8.3kJPN chr21:42629245 rs761187359 |
- | 0.0004 | 0.0888 | - | |
| 371_CYS | PHE |
8.3kJPN chr21:42629248 rs1206170769 |
- | 0.0001 | 0.9879 | - | |
| 385_PRO | LEU |
8.3kJPN chr21:42647334 - |
- | 0.0001 | 0.4774 | - | |
| 398_ALA | THR |
gnomAD chr21:42647372 rs149345353 |
- | 0.00314583 | 0.0622 | - |