| PDB ID | 2CNX
|
CHAIN | A |
|---|---|---|---|
| Protein name | WD-REPEAT PROTEIN 5 | ||
| Uniprot Accession | P61964 | ||
| The number of similar proteins | 181 | ||
| The number of binding states | 9 | ||
| The number of binding partners | 7 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 2CNX (CHAIN: A) | |
| 1 | Monomeric state |
| 2 |
P61964
|
| 3 |
P60484
|
| 4 |
C0HLS1
|
| 5 |
Q9Y4B6
|
| 6 |
P40337
|
| 7 |
6BYN
|
| 8 |
P61965
Q80Z64
|
| 9 |
P61965
P61965
Q80Z64
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 33_PRO | SER |
8.3kJPN chr3:122134291 rs756380759 |
- | 0.0001 | 0.908 | - | |
| 34_ASN | ASP |
8.3kJPN chr9:137005843 rs190487971 |
- | 0.0002 | 0.1692 | - | |
| 45_THR | MET |
gnomAD chr3:122134254 rs142943736 |
- | 0.000413552 | 0.1537 | - | |
| 48_VAL | GLY |
8.3kJPN chr3:122134245 - |
- | 0.0001 | 0.9825 | - | |
| 59_TRP | ARG |
ClinVar chr9:137005918 - |
Likely pathogenic | - | 0.9687 | WDR5-related neurodevelopmental delay [-] | |
| 59_TRP | ARG |
8.3kJPN chr3:122134213 rs748516360 |
- | 0.0002 | 0.9687 | - | |
| 86_HIS | ARG |
8.3kJPN chr3:122134131 - |
- | 0.0001 | 0.9916 | - | |
| 118_SER | TYR |
8.3kJPN chr3:122134035 rs138368985 |
- | 0.0004 | 0.3531 | - | |
| 119_GLY | GLU |
gnomAD chr3:122134032 rs61736421 |
- | 0.00646855 | 0.8662 | - | |
| 158_VAL | LEU |
8.3kJPN chr3:122133916 - |
- | 0.0001 | 0.662 | - | |
| 161_GLY | GLU |
8.3kJPN chr3:122133906 rs1370488638 |
- | 0.0001 | 0.9934 | - | |
| 163_CYS | ARG |
8.3kJPN chr3:122133901 rs1318887544 |
- | 0.0003 | 0.9938 | - | |
| 196_ARG | CYS |
ClinVar chr9:137017106 - |
Pathogenic | - | - | not provided [MedGen:C3661900] | |
| 208_THR | MET |
VAR_081531
- |
US | - | 0.9658 | - | |
| 208_THR | MET |
ClinVar chr9:137017143 rs2539710078 |
Pathogenic | - | 0.9658 | not provided [MedGen:C3661900] | |
| 210_VAL | ILE |
8.3kJPN chr3:122133760 - |
- | 0.0001 | - | - | |
| 215_PRO | SER |
8.3kJPN chr3:122133745 rs1052985272 |
- | 0.0003 | 0.9127 | - | |
| 232_ALA | THR |
8.3kJPN chr9:137019650 - |
- | 0.0001 | 0.878 | - | |
| 237_THR | ALA |
8.3kJPN chr3:122133679 - |
- | 0.0001 | 0.3189 | - | |
| 239_LYS | ASN |
gnomAD chr3:122133671 rs375158653 |
- | 0.000151329 | 0.996 | - | |
| 262_ILE | VAL |
gnomAD chr9:137020857 rs200750750 |
- | 0.000107369 | 0.0728 | - | |
| 262_ILE | VAL |
8.3kJPN chr9:137020857 rs200750750 |
- | 0.0031 | 0.0728 | - | |
| 282_LEU | VAL |
gnomAD chr3:122133544 rs137887894 |
- | 0.00011144 | - | - | |
| 285_ILE | VAL |
8.3kJPN chr3:122133535 rs750984921 |
- | 0.0001 | 0.1257 | - | |
| 293_ILE | THR |
8.3kJPN chr3:122133510 rs141407605 |
- | 0.0001 | 0.1973 | - | |
| 300_HIS | ASP |
8.3kJPN chr3:122133490 - |
- | 0.0001 | 0.9934 | - | |
| 303_VAL | ASP |
gnomAD chr3:122133480 rs140462855 |
- | 0.000385987 | 0.9646 | - | |
| 303_VAL | ASP |
8.3kJPN chr3:122133480 rs140462855 |
- | 0.0011 | 0.9646 | - | |
| 316_ILE | PHE |
8.3kJPN chr9:137023056 - |
- | 0.0001 | 0.9387 | - | |
| 318_SER | CYS |
8.3kJPN chr9:137023063 - |
- | 0.0001 | 0.8957 | - | |
| 324_ASP | TYR |
8.3kJPN chr3:122133418 - |
- | 0.0001 | 0.9966 | - | |
| 330_TRP | ARG |
8.3kJPN chr3:122133400 - |
- | 0.0001 | 0.9996 | - |