PDB ID 2B5L     CHAIN A
Protein name damage-specific DNA binding protein 1
GenBank ID 13435359
The number of similar proteins 42
The number of binding states 9
The number of binding partners 9

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
2B5L (CHAIN: A)
1 P11207  
2 Monomeric state
3 Q92466  
4 Q9Y4B6  
5 Q96SW2  
6 Q13216  
7 Q13619   P11207  
8 P00720   Q9Y4B6  
9 Q9BW61   Q66K64  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MSYNYVVTAQ   KPTAVNGCVT   GHFTSAEDLN   LLIAKNTRLE   IYVVTAEGLR   50
51   PVKEVGMYGK   IAVMELFRPK   GESKDLLFIL   TAKYNACILE   YKQSGESIDI   100
101   ITRAHGNVQD   RIGRPSETGI   IGIIDPECRM   IGLRLYDGLF   KVIPLDRDNK   150
151   ELKAFNIRLE   ELHVIDVKFL   YGCQAPTICF   VYQDPQGRHV   KTYEVSLREK   200
201   EFNKGPWKQE   NVEAEASMVI   AVPEPFGGAI   IIGQESITYH   NGDKYLAIAP   250
251   PIIKQSTIVC   HNRVDPNGSR   YLLGDMEGRL   FMLLLEKEEQ   MDGTVTLKDL   300
301   RVELLGETSI   AECLTYLDNG   VVFVGSRLGD   SQLVKLNVDS   NEQGSYVVAM   350
351   ETFTNLGPIV   DMCVVDLERQ   GQGQLVTCSG   AFKEGSLRII   RNGIGIHEHA   400
401   SIDLPGIKGL   WPLRSDPNRE   TYDTLVLSFV   GQTRVLMLNG   EEVEETELMG   450
451   FVDDQQTFFC   GNVAHQQLIQ   ITSASVRLVS   QEPKALVSEW   KEPQAKNISV   500
501   ASCNSSQVVV   AVGRALYYLQ   IHPQELRQIS   HTEMEHEVAC   LDITPLGDSN   550
551   GLSPLCAIGL   WTDISARILK   LPSFELLHKE   MLGGEIIPRS   ILMTTFESSH   600
601   YLLCALGDGA   LFYFGLNIET   GLLSDRKKVT   LGTQPTVLRT   FRSLSTTNVF   650
651   ACSDRPTVIY   SSNHKLVFSN   VNLKEVNYMC   PLNSDGYPDS   LALANNSTLT   700
701   IGTIDEIQKL   HIRTVPLYES   PRKICYQEVS   QCFGVLSSRI   EVQDTSGGTT   750
751   ALRPSASTQA   LSSSVSSSKL   FSSSTAPHET   SFGEEVEVHN   LLIIDQHTFE   800
801   VLHAHQFLQN   EYALSLVSCK   LGKDPNTYFI   VGTAMVYPEE   AEPKQGRIVV   850
851   FQYSDGKLQT   VAEKEVKGAV   YSMVEFNGKL   LASINSTVRL   YEWTTEKDVR   900
901   TECNHYNNIM   ALYLKTKGDF   ILVGDLMRSV   LLLAYKPMEG   NFEEIARDFN   950
951   PNWMSAVEIL   DDDNFLGAEN   AFNLFVCQKD   SAATTDEERQ   HLQEVGLFHL   1000
1001   GEFVNVFCHG   SLVMQNLGET   STPTQGSVLF   GTVNGMIGLV   TSLSESWYNL   1050
1051   LLDMQNRLNK   VIKSVGKIEH   SFWRSFHTER   KTEPATGFID   GDLIESFLDI   1100
1101   SRPKMQEVVA   NLQYDDGSGM   KREATADDLI   KVVEELTRIH     1150

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
18_CYS GLY 8.3kJPN
chr11:61100389
-
- 0.0001 - -
25_SER LEU gnomAD
chr11:61099151
rs35597036
- 0.000743592 - -
25_SER ALA 8.3kJPN
chr11:61099152
-
- 0.0001 - -
40_GLU ASP 8.3kJPN
chr11:61099105
-
- 0.0001 - -
68_ARG TRP 8.3kJPN
chr11:61099023
-
- 0.0001 - -
102_THR MET 8.3kJPN
chr11:61097452
rs754320597
- 0.0001 - -
114_ARG HIS ClinVar
chr11:61097043
rs1231861984
Likely pathogenic - - Neurodevelopmental delay [Human Phenotype Ontology:HP:0012758,MedGen:C4022738]
157_ILE ASN 8.3kJPN
chr11:61096914
-
- 0.0001 - -
188_ARG GLN ClinVar
chr11:61094352
rs2134935097
Pathogenic - - White-Kernohan syndrome [MONDO:MONDO:0859169,MedGen:C5543635,OMIM:619426]
213_GLU LYS ClinVar
chr11:61094278
rs2134934938
Likely pathogenic - - White-Kernohan syndrome [MONDO:MONDO:0859169,MedGen:C5543635,OMIM:619426]
241_ASN SER 8.3kJPN
chr11:61093123
rs1169556093
- 0.0001 - -
252_ILE VAL 8.3kJPN
chr11:61093091
rs1200909412
- 0.0002 - -
295_VAL ILE 8.3kJPN
chr11:61091489
rs756108667
- 0.0001 - -
314_LEU PHE 8.3kJPN
chr11:61090546
-
- 0.0001 - -
340_SER ILE 8.3kJPN
chr11:61089871
-
- 0.0001 - -
414_ARG TRP 8.3kJPN
chr11:61084025
rs769032698
- 0.0001 - -
419_ARG LEU 8.3kJPN
chr11:61084009
rs553181699
- 0.0016 - -
422_ASP ASN 8.3kJPN
chr11:61084001
-
- 0.0001 - -
429_PHE VAL ClinVar
chr11:61083980
rs2134916397
Pathogenic - - White-Kernohan syndrome [MONDO:MONDO:0859169,MedGen:C5543635,OMIM:619426]
462_ASN SER gnomAD
chr11:61083782
rs756660357
- 0.000512984 - -
475_SER LEU gnomAD
chr11:61081945
rs769682007
- 0.000100784 - -
475_SER LEU 8.3kJPN
chr11:61081945
rs778820024
- 0.0001 - -
507_GLN LYS 8.3kJPN
chr11:61081850
-
- 0.0001 - -
517_TYR CYS gnomAD
chr11:61081819
rs56006697
- 0.000211093 - -
517_TYR CYS 8.3kJPN
chr11:61081819
rs56006697
- 0.0011 - -
527_ARG TRP 8.3kJPN
chr11:61081790
-
- 0.0001 - -
548_ASP GLY 8.3kJPN
chr11:61081629
rs757720014
- 0.0003 - -
626_ARG HIS 8.3kJPN
chr11:61081163
rs767530118
- 0.0001 - -
626_ARG CYS 8.3kJPN
chr11:61081164
rs1302192657
- 0.0001 - -
642_ARG HIS 8.3kJPN
chr11:61081115
rs376616995
- 0.0002 - -
649_VAL ILE 8.3kJPN
chr11:61081095
rs1194687578
- 0.0001 - -
739_ARG HIS 8.3kJPN
chr11:61079317
rs190054116
- 0.0001 - -
781_SER ALA 8.3kJPN
chr11:61077827
-
- 0.0001 - -
790_ASN HIS 8.3kJPN
chr11:61077800
rs759310673
- 0.0001 - -
805_HIS TYR 8.3kJPN
chr11:61077421
-
- 0.0001 - -
859_GLN ARG 8.3kJPN
chr11:61076540
-
- 0.0001 - -
971_ALA GLY 8.3kJPN
chr11:61070548
-
- 0.0001 - -
978_GLN ARG 8.3kJPN
chr11:61070527
-
- 0.0001 - -
1022_THR SER 8.3kJPN
chr11:61070101
-
- 0.0001 - -
1059_ASN SER 8.3kJPN
chr11:61069768
rs1197372725
- 0.0001 - -
1069_GLU LYS 8.3kJPN
chr11:61069739
-
- 0.0001 - -
1071_SER CYS 8.3kJPN
chr11:61069732
-
- 0.0001 - -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.