PDB ID 2AZ5     CHAIN A
Protein name Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]
Uniprot Accession P01375
The number of similar proteins 144
The number of binding states 25
The number of binding partners 8

Molecule viewer


Only interaction residues
#binding
partners
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   DKPVAHVVAN   PQAEGQLQWL   NRRANALLAN   GVELRDNQLV   VPSEGLYLIY   50
51   SQVLFKGQGC   PSTHVLLTHT   ISRIAVSYQT   KVNLLSAIKS   PCQRETPEGA   100
101   EAKPWYEPIY   LGGVFQLEKG   DRLSAEINRP   DYLDFAESGQ   VYFGIIAL   150

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
18_ALA THR VAR_011927
rs1800620
LB/B - 0.6562 -
41_VAL MET 8.3kJPN
chr6:31544961
rs548532642
- 0.0001 0.1252 -
72_THR SER 8.3kJPN
chr6:31545055
-
- 0.0001 0.0587 -
85_VAL ILE gnomAD
chr6:31545093
rs373646181
- 0.000101197 0.088 -
85_VAL ILE 8.3kJPN
chr6:31545093
rs373646181
- 0.0002 0.088 -
118_ILE ASN gnomAD
chr6:31545193
rs11574936
- 0.000352864 0.8326 -
118_ILE ASN 8.3kJPN
chr6:31545193
rs11574936
- 0.0004 0.8326 -
138_ARG GLN 8.3kJPN
chr6:31545253
rs770509340
- 0.0001 0.071 -
140_ASP ASN 8.3kJPN
chr6:31545258
rs370893734
- 0.0001 0.0729 -
146_GLU ASP 8.3kJPN
chr6:31545278
-
- 0.0001 0.1529 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.