PiSITE

PDB ID	1Z8J	CHAIN	A
Protein name	Thrombin light chain
Uniprot Accession	P00734
The number of similar proteins	351
The number of binding states	7
The number of binding partners	6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	1Z8J (CHAIN: A)
1	P00734
2	Monomeric state
3	P00734 P01008
4	P00734 P00734
5	P00734 P00734
6	P00734 P00734 P00734
7	P00734 P00734 P00734

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Molecule viewer

Only interaction residues

#binding
partners

	4
	3
	2
	1
	0

Sequence information

1

TFFNPRTFGS

GEADCGLRPL

FEKKSLEDKT

ERELLESYID

50

Variants

	Residue	AA	Source / dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	AlphaMissense pathogenicity	Disease name
	1D_GLY	ALA	ClinVar chr11:46748168 rs2134532862	Likely pathogenic	-	0.5212	Congenital prothrombin deficiency [MONDO:MONDO:0013361,MedGen:C0272317,OMIM:613679,Orphanet:325]
	1E_SER	LEU	8.3kJPN chr11:46748165 rs200812621	-	0.0004	0.0591	-
	4_ARG	TER	ClinVar chr11:46748272 -	Pathogenic	-	-	Congenital prothrombin deficiency [MONDO:MONDO:0013361,MedGen:C0272317,OMIM:613679,Orphanet:325]
	8_GLU	LYS	ClinVar chr11:46748284 rs121918483	Pathogenic	-	0.8559	Congenital prothrombin deficiency [MONDO:MONDO:0013361,MedGen:C0272317,OMIM:613679,Orphanet:325]
	14C_GLU	LYS	ClinVar chr11:46748311 rs121918484	Pathogenic	-	0.692	Congenital prothrombin deficiency [MONDO:MONDO:0013361,MedGen:C0272317,OMIM:613679,Orphanet:325]
	14H_GLU	GLY	ClinVar chr11:46748327 rs2134533215	Likely pathogenic	-	0.1036	Congenital prothrombin deficiency [MONDO:MONDO:0013361,MedGen:C0272317,OMIM:613679,Orphanet:325]

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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364