PDB ID 1YWH     CHAIN A
Protein name Urokinase plasminogen activator surface receptor
Uniprot Accession Q9UMV0
The number of similar proteins 20
The number of binding states 8
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1YWH (CHAIN: A)
1 Q9UMV0   Q9UMV0   Q9UMV0  
2 Monomeric state
3 P00749  
4 Q03405  
5 4QTI   4QTI  
6 P04004   P00749  
7 Q52L64   Q4V9V8   P00749  
8 3BT2   3BT2   P04004   P00749  

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Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   LRCMQCKTNG   DCRVEECALG   QDLCRTTIVR   LWEEGEELEL   VEKSCTHSEK   50
51   TNRTLSYRTG   LKITSLTEVV   CGLDLCNQGN   SGRAVTYSRS   RYLECISCGS   100
101   SDMSCERGRH   QSLQCRSPEE   QCLDVVTHWI   QEGEEGRPKD   DRHLRGCGYL   150
151   PGCPGSNGFH   NNDTFHFLKC   CNTTKCNEGP   ILELENLPQN   GRQCYSCKGQ   200
201   STHGCSSEET   FLIDCRGPMN   QCLVATGTHE   PKNQSYMVRG   CATASMCQHA   250
251   HLGDAFSMNH   IDVSCCTKSG   CNHPDLDVQY   RSGAAPQPGP   AHLSLTITLL   300
301   MTARLWGGTL   LWT         350

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
4_MET ILE 8.3kJPN
chr19:44171821 		-
- 0.0001 -
16_GLU LYS 8.3kJPN
chr19:44171787 		-
- 0.0001 -
20_GLY VAL 8.3kJPN
chr19:44171774 		rs1201479506
- 0.0001 -
22_ASP HIS 8.3kJPN
chr19:44171769 		rs778790349
- 0.0001 -
23_LEU PHE 8.3kJPN
chr19:44171766 		-
- 0.0001 -
58_ARG TRP 8.3kJPN
chr19:44169540 		rs752525518
- 0.0001 -
64_THR ALA gnomAD
chr19:44169522 		rs399145
- 0.00823492 -
72_GLY GLU gnomAD
chr19:44169497 		rs150986089
- 0.00100602 -
74_ASP ASN 8.3kJPN
chr19:44169492 		-
- 0.0001 -
89_ARG GLN 8.3kJPN
chr19:44160771 		rs753893509
- 0.0001 -
91_ARG CYS 8.3kJPN
chr19:44160766 		rs531645411
- 0.0001 -
95_CYS ARG 8.3kJPN
chr19:44160754 		-
- 0.0002 -
109_ARG TRP 8.3kJPN
chr19:44160712 		rs772718099
- 0.0001 -
137_ARG HIS gnomAD
chr19:44159722 		rs140011964
- 0.00140113 -
140_ASP GLY 8.3kJPN
chr19:44159713 		-
- 0.0001 -
145_ARG HIS 8.3kJPN
chr19:44159698 		rs1157998153
- 0.0001 -
149_TYR CYS 8.3kJPN
chr19:44159686 		rs763744500
- 0.0005 -
157_ASN SER gnomAD
chr19:44159662 		rs138306315
- 0.000242579 -
188_PRO LEU gnomAD
chr19:44156502 		rs141507706
- 0.000811385 -
198_LYS ARG gnomAD
chr19:44156472 		rs2302524
- 0.163056 -
198_LYS ARG 8.3kJPN
chr19:44156472 		rs2302524
- 0.1112 -
199_GLY ARG gnomAD
chr19:44156470 		rs542078792
- 0.000922546 -
209_GLU VAL 8.3kJPN
chr19:44156439 		-
- 0.0001 -
213_ILE THR 8.3kJPN
chr19:44156427 		-
- 0.0008 -
230_GLU LYS 8.3kJPN
chr19:44156377 		rs757884538
- 0.0002 -
237_MET THR 8.3kJPN
chr19:44153274 		-
- 0.0001 -
239_ARG LYS 8.3kJPN
chr19:44153268 		-
- 0.0001 -
246_MET VAL gnomAD
chr19:44153248 		rs138492321
- 0.00361124 -
255_ALA THR 8.3kJPN
chr19:44153221 		rs750492027
- 0.0001 -
259_ASN LYS gnomAD
chr19:44153207 		rs4251921
- 0.000866992 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.