PiSITE

PDB ID	1WXS	CHAIN	A
Protein name	Ubiquitin-fold Modifier 1
Uniprot Accession	P61960
The number of similar proteins	19
The number of binding states	6
The number of binding partners	4

Molecule viewer

Only interaction residues

#binding
partners

1

GPLGSMSKVS

FKITLTSDPR

LPYKVLSVPE

STPFTAVLKF

AAEEFKVPAA

50

51

TSAIITNDGI

GINPAQTAGN

VFLKHGSELR

IIPRDRVGSC

100

Ubiquitin-fold modifier-conjugating enzyme 1

Ubiquitin-fold modifier 1

Ufm1-specific protease

	Q9GZZ9	Ubiquitin-like modifier-activating enzyme 5
	Q9GZZ9	Ubiquitin-like modifier-activating enzyme 5

	Q94218	Ufm1-specific protease
	Q94218	Ufm1-specific protease

Residue	AA	Source / dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	AlphaMissense pathogenicity	Disease name
1_MET	VAL	ClinVar chr13:38924057 -	Likely pathogenic	-	0.1183	Leukodystrophy, hypomyelinating, 14 [MONDO:MONDO:0033486,MedGen:C4693535,OMIM:617899]
19_LYS	GLU	8.3kJPN chr13:38924188 rs371109857	-	0.0001	0.9912	-
48_ALA	VAL	8.3kJPN chr13:38932255 rs1329632534	-	0.0001	0.9967	-
49_ILE	VAL	8.3kJPN chr13:38932257 rs556026347	-	0.0001	0.0675	-
59_PRO	LEU	8.3kJPN chr13:38933456 -	-	0.0003	0.958	-
75_ARG	GLN	8.3kJPN chr13:38934881 rs372717462	-	0.0001	0.969	-
81_ARG	CYS	VAR_081218 rs1033946108	LP/P	-	0.9802	Leukodystrophy, hypomyelinating, 14 (HLD14) [MIM:617899]
81_ARG	CYS	ClinVar chr13:38934898 rs1033946108	Pathogenic	-	0.9802	Leukodystrophy, hypomyelinating, 14 [MONDO:MONDO:0033486,MedGen:C4693535,OMIM:617899]

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