PDB ID 1WXS     CHAIN A
Protein name Ubiquitin-fold Modifier 1
Uniprot Accession P61960
The number of similar proteins 19
The number of binding states 6
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1WXS (CHAIN: A)
1 Monomeric state
2 Q9Y3C8  
3 P61960  
4 Q94218  
5 Q9GZZ9   Q9GZZ9  
6 Q94218   Q94218  

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Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   GPLGSMSKVS   FKITLTSDPR   LPYKVLSVPE   STPFTAVLKF   AAEEFKVPAA   50
51   TSAIITNDGI   GINPAQTAGN   VFLKHGSELR   IIPRDRVGSC     100

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
1_MET VAL ClinVar
chr13:38924057 		-
Likely pathogenic - Leukodystrophy, hypomyelinating, 14 [MONDO:MONDO:0033486,MedGen:C4693535,OMIM:617899]
19_LYS GLU 8.3kJPN
chr13:38924188 		rs371109857
- 0.0001 -
48_ALA VAL 8.3kJPN
chr13:38932255 		rs1329632534
- 0.0001 -
49_ILE VAL 8.3kJPN
chr13:38932257 		rs556026347
- 0.0001 -
59_PRO LEU 8.3kJPN
chr13:38933456 		-
- 0.0003 -
75_ARG GLN 8.3kJPN
chr13:38934881 		rs372717462
- 0.0001 -
81_ARG CYS VAR_081218 rs1033946108
LP/P - Leukodystrophy, hypomyelinating, 14 (HLD14) [MIM:617899]
81_ARG CYS ClinVar
chr13:38934898 		rs1033946108
Pathogenic - Leukodystrophy, hypomyelinating, 14 [MONDO:MONDO:0033486,MedGen:C4693535,OMIM:617899]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.