PDB ID 1SKO     CHAIN A
Protein name Mitogen-activated protein kinase kinase 1 interacting protein 1
Uniprot Accession Q9UHA4
The number of similar proteins 13
The number of binding states 4
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1SKO (CHAIN: A)
1 Q9JHS3  
2 Q99K70   Q6IAA8   O43504   Q9Y2Q5  
3 Q6IAA8   O43504   Q9Y2Q5   Q0VGL1  
4 O43504   Q9Y2Q5   Q0VGL1   Q6IAA8  

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Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   MGSSHHHHHH   HHENLYFQGS   ADDLKRFLYK   KLPSVEGLHA   IVVSDRDGVP   50
51   VIKVANDNAP   EHALRPGFLS   TFALATDQGS   KLGLSKNKSI   ICYYNTYQVV   100
101   QFNRLPLVVS   FIASSSANTG   LIVSLEKELA   PLFEELRQVV   EVS   150

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
3_ALA VAL 8.3kJPN
chr4:100815116
-
- 0.0001 0.774 -
65_GLY GLU 8.3kJPN
chr4:100806745
rs1183207968
- 0.0001 0.9986 -
84_PHE LEU gnomAD
chr4:100805273
rs199789066
- 0.000195057 0.9544 -
86_ARG HIS 8.3kJPN
chr4:100805266
rs765881637
- 0.0001 0.1449 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.