| PDB ID | 1RKC
|
CHAIN | A |
|---|---|---|---|
| Protein name | Vinculin | ||
| Uniprot Accession | P18206 | ||
| The number of similar proteins | 25 | ||
| The number of binding states | 8 | ||
| The number of binding partners | 7 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1RKC (CHAIN: A) | |
| 1 | Monomeric state |
| 2 |
P18206
|
| 3 |
32307018
|
| 4 |
Q7Z5R6
|
| 5 |
Q8AWI0
|
| 6 |
P26231
|
| 7 |
P26231
|
| 8 |
P26039
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 46_ALA | SER |
8.3kJPN chr10:75758101 - |
- | 0.0001 | 0.1935 | - | |
| 94_MET | ILE |
8.3kJPN chr10:75830470 rs774870551 |
- | 0.0002 | 0.8166 | - | |
| 105_ARG | TER |
8.3kJPN chr10:75830501 rs397517239 |
- | 0.0001 | - | - | |
| 135_ILE | THR |
gnomAD chr10:75830746 rs373744314 |
- | 0.00050152 | 0.9056 | - | |
| 188_ARG | GLN |
8.3kJPN chr10:75832551 rs770173689 |
- | 0.0001 | 0.3579 | - | |
| 191_LEU | SER |
8.3kJPN chr10:75832560 rs1215944445 |
- | 0.0001 | 0.9994 | - | |
| 197_THR | ILE |
gnomAD chr10:75832578 rs189242810 |
- | 0.000274454 | 0.271 | - | |
| 209_MET | LEU |
8.3kJPN chr10:75834503 rs144683137 |
- | 0.0008 | 0.359 | - | |
| 215_THR | ILE |
8.3kJPN chr10:75834522 rs1287472049 |
- | 0.0001 | 0.5433 | - | |
| 230_ARG | HIS |
8.3kJPN chr10:75834567 rs749628307 |
- | 0.0001 | 0.8875 | - | |
| 234_VAL | LEU |
VAR_037667
rs17853882 |
LB/B | - | 0.4184 | - | |
| 237_MET | ILE |
8.3kJPN chr10:75834589 - |
- | 0.0001 | 0.9344 | - | |
| 238_SER | ARG |
8.3kJPN chr10:75834592 - |
- | 0.0001 | 0.825 | - | |
| 246_ARG | HIS |
8.3kJPN chr10:75834615 rs746577068 |
- | 0.0001 | 0.7833 | - |