PDB ID 1QGK     CHAIN A
Protein name PROTEIN (IMPORTIN BETA SUBUNIT)
Uniprot Accession Q14974
The number of similar proteins 8
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1QGK (CHAIN: A)
1 P52292  
2 Monomeric state
3 O95149  
4 O95863  
5 Q12772   Q12772  

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Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   MELITILEKT   VSPDRLELEA   AQKFLERAAV   ENLPTFLVEL   SRVLANPGNS   50
51   QVARVAAGLQ   IKNSLTSKDP   DIKAQYQQRW   LAIDANARRE   VKNYVLHTLG   100
101   TETYRPSSAS   QCVAGIACAE   IPVNQWPELI   PQLVANVTNP   NSTEHMKEST   150
151   LEAIGYICQD   IDPEQLQDKS   NEILTAIIQG   MRKEEPSNNV   KLAATNALLN   200
201   SLEFTKANFD   KESERHFIMQ   VVCEATQCPD   TRVRVAALQN   LVKIMSLYYQ   250
251   YMETYMGPAL   FAITIEAMKS   DIDEVALQGI   EFWSNVCDEE   MDLAIEASEA   300
301   AEQGRPPEHT   SKFYAKGALQ   YLVPILTQTL   TKQDENDDDD   DWNPCKAAGV   350
351   CLMLLATCCE   DDIVPHVLPF   IKEHIKNPDW   RYRDAAVMAF   GCILEGPEPS   400
401   QLKPLVIQAM   PTLIELMKDP   SVVVRDTAAW   TVGRICELLP   EAAINDVYLA   450
451   PLLQCLIEGL   SAEPRVASNV   CWAFSSLAEA   AYEAADVADD   QEEPATYCLS   500
501   SSFELIVQKL   LETTDRPDGH   QNNLRSSAYE   SLMEIVKNSA   KDCYPAVQKT   550
551   TLVIMERLQQ   VLQMESHIQS   TSDRIQFNDL   QSLLCATLQN   VLRKVQHQDA   600
601   LQISDVVMAS   LLRMFQSTAG   SGGVQEDALM   AVSTLVEVLG   GEFLKYMEAF   650
651   KPFLGIGLKN   YAEYQVCLAA   VGLVGDLCRA   LQSNIIPFCD   EVMQLLLENL   700
701   GNENVHRSVK   PQILSVFGDI   ALAIGGEFKK   YLEVVLNTLQ   QASQAQVDKS   750
751   DYDMVDYLNE   LRESCLEAYT   GIVQGLKGDQ   ENVHPDVMLV   QPRVEFILSF   800
801   IDHIAGDEDH   TDGVVACAAG   LIGDLCTAFG   KDVLKLVEAR   PMIHELLTEG   850
851   RRSKTNKAKT   LARWATKELR   KLKNQA       900

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
35_THR SER 8.3kJPN
chr17:45730064
-
- 0.0002 0.0703 -
70_PRO ALA gnomAD
chr17:45730168
rs61750353
- 0.00634034 0.0572 -
71_ASP ASN gnomAD
chr17:45730171
rs199885874
- 0.000140376 0.0621 -
79_ARG LYS 8.3kJPN
chr17:45730196
-
- 0.0001 0.3481 -
83_ILE VAL gnomAD
chr17:45730207
rs200458673
- 0.000303926 0.0728 -
181_MET LEU 8.3kJPN
chr17:45735931
-
- 0.0001 0.876 -
205_THR ILE 8.3kJPN
chr17:45736004
-
- 0.0001 0.9447 -
381_ARG GLN 8.3kJPN
chr17:45745694
rs776002778
- 0.0001 0.1769 -
462_ALA THR 8.3kJPN
chr17:45747203
-
- 0.0002 0.1406 -
487_VAL ILE gnomAD
chr17:45748110
rs202234934
- 0.000115371 0.0693 -
487_VAL ILE 8.3kJPN
chr17:45748110
rs202234934
- 0.0001 0.0693 -
553_VAL ILE 8.3kJPN
chr17:45750493
-
- 0.0001 0.0984 -
640_GLY ASP 8.3kJPN
chr17:45753781
-
- 0.0001 0.7589 -
770_THR SER 8.3kJPN
chr17:45755735
-
- 0.0001 0.5622 -
844_HIS TYR 8.3kJPN
chr17:45757935
rs774190588
- 0.0002 0.0936 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.