| PDB ID | 1OZN
|
CHAIN | A |
|---|---|---|---|
| Protein name | Reticulon 4 receptor | ||
| Uniprot Accession | Q9BZR6 | ||
| The number of similar proteins | 21 | ||
| The number of binding states | 5 | ||
| The number of binding partners | 4 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1OZN (CHAIN: A) | |
| 1 | Monomeric state |
| 2 |
Q99PI8
|
| 3 |
Q3UHD1
|
| 4 |
3KJ4
3KJ4
|
| 5 |
Q99PI8
Q99PI8
Q99PI8
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 39_VAL | MET |
8.3kJPN chr22:20230541 - |
- | 0.0001 | 0.2692 | - | |
| 53_VAL | MET |
VAR_079224
rs145292678 |
LB/B | - | 0.0926 | - | |
| 53_VAL | LEU |
8.3kJPN chr22:20230499 - |
- | 0.0001 | 0.0712 | - | |
| 66_GLY | SER |
gnomAD chr22:20230460 rs56235791 |
- | 0.000256402 | 0.1274 | - | |
| 68_ARG | HIS |
VAR_079225
rs145773589 |
LB/B | - | 0.0851 | - | |
| 68_ARG | HIS |
gnomAD chr22:20230453 rs145773589 |
- | 0.000130768 | 0.0851 | - | |
| 68_ARG | HIS |
8.3kJPN chr22:20230453 rs145773589 |
- | 0.0025 | 0.0851 | - | |
| 116_ALA | SER |
8.3kJPN chr22:20230310 rs775520463 |
- | 0.0001 | 0.0833 | - | |
| 119_ARG | TRP |
VAR_079154
rs74315508 |
LP/P | - | 0.1118 | Schizophrenia (SCZD) [MIM:181500] | |
| 119_ARG | TRP |
gnomAD chr22:20230301 rs74315508 |
- | 0.000352378 | 0.1118 | - | |
| 124_ALA | PRO |
8.3kJPN chr22:20230286 - |
- | 0.0001 | 0.2085 | - | |
| 131_ARG | HIS |
gnomAD chr22:20230264 rs144276737 |
- | 0.000146294 | 0.0834 | - | |
| 131_ARG | HIS |
8.3kJPN chr22:20230264 rs144276737 |
- | 0.0003 | 0.0834 | - | |
| 141_GLY | SER |
VAR_079226
rs760855779 |
LB/B | - | 0.1689 | - | |
| 147_PRO | LEU |
8.3kJPN chr22:20230216 rs113041746 |
- | 0.0001 | 0.1041 | - | |
| 149_LEU | MET |
gnomAD chr22:20230211 rs375571554 |
- | 0.000105874 | 0.2476 | - | |
| 172_ASP | GLU |
gnomAD chr22:20230140 rs117955118 |
- | 0.000103915 | 0.2378 | - | |
| 172_ASP | GLU |
8.3kJPN chr22:20230140 rs117955118 |
- | 0.0009 | 0.2378 | - | |
| 177_LEU | PRO |
8.3kJPN chr22:20230126 - |
- | 0.0001 | 0.9063 | - | |
| 184_PHE | LEU |
8.3kJPN chr22:20230106 - |
- | 0.0001 | 0.9975 | - | |
| 187_GLY | SER |
gnomAD chr22:20230097 rs770160195 |
- | 0.000115757 | 0.2398 | - | |
| 196_ARG | HIS |
VAR_079155
rs74315509 |
LP/P | - | 0.0775 | Schizophrenia (SCZD) [MIM:181500] | |
| 227_ARG | CYS |
VAR_079227
rs754793885 |
US | - | 0.397 | Schizophrenia (SCZD) [MIM:181500] | |
| 227_ARG | HIS |
VAR_079228
rs576939822 |
LB/B | - | 0.0955 | - | |
| 227_ARG | HIS |
8.3kJPN chr22:20229976 rs576939822 |
- | 0.0001 | 0.0955 | - | |
| 259_ASP | ASN |
VAR_079229
rs3747073 |
LB/B | - | 0.1298 | - | |
| 259_ASP | ASN |
8.3kJPN chr22:20229881 rs3747073 |
- | 0.004 | 0.1298 | - | |
| 263_VAL | MET |
VAR_079230
rs752810777 |
LB/B | - | 0.2277 | - | |
| 263_VAL | MET |
8.3kJPN chr22:20229869 rs752810777 |
- | 0.0001 | 0.2277 | - | |
| 267_ARG | GLN |
8.3kJPN chr22:20229856 rs1213179762 |
- | 0.0001 | 0.0991 | - | |
| 269_ARG | HIS |
gnomAD chr22:20229850 rs548639274 |
- | 0.000105527 | 0.1248 | - | |
| 279_ARG | HIS |
gnomAD chr22:20229820 rs144550064 |
- | 0.000151387 | 0.1256 | - | |
| 292_ARG | HIS |
VAR_079231
rs1432033565 |
LP/P | - | 0.0706 | Schizophrenia (SCZD) [MIM:181500] | |
| 292_ARG | HIS |
8.3kJPN chr22:20229781 rs1432033565 |
- | 0.0002 | 0.0706 | - |