| PDB ID | 1MQ4
|
CHAIN | A |
|---|---|---|---|
| Protein name | AURORA-RELATED KINASE 1 | ||
| Uniprot Accession | O14965 | ||
| The number of similar proteins | 201 | ||
| The number of binding states | 11 | ||
| The number of binding partners | 6 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1MQ4 (CHAIN: A) | |
| 1 | Monomeric state |
| 2 |
8SSP
|
| 3 |
P04198
|
| 4 |
Q8JJ25
|
| 5 |
Q9Y6A5
|
| 6 |
Q9ULW0
|
| 7 |
Q9ULW0
|
| 8 |
Q8TEP8
Q8TEP8
|
| 9 |
O14965
6C83
6C83
|
| 10 |
O14965
Q9ULW0
Q9ULW0
|
| 11 |
O14965
O14965
O14965
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 155_SER | ARG |
VAR_041128
- |
US | - | 0.9234 | A colorectal adenocarcinoma sample | |
| 174_VAL | MET |
VAR_041129
- |
US | - | 0.4752 | A metastatic melanoma sample | |
| 174_VAL | ALA |
8.3kJPN chr20:54958086 - |
- | 0.0001 | 0.821 | - | |
| 189_ARG | TRP |
8.3kJPN chr20:54958042 rs779964295 |
- | 0.0001 | 0.4246 | - | |
| 223_GLN | LYS |
8.3kJPN chr20:54956527 rs1217224639 |
- | 0.0006 | 0.1693 | - | |
| 279_VAL | ILE |
8.3kJPN chr20:54948483 - |
- | 0.0002 | 0.2692 | - | |
| 305_MET | LYS |
8.3kJPN chr20:54945656 - |
- | 0.0002 | 0.2098 | - | |
| 309_LYS | GLU |
8.3kJPN chr20:54945645 - |
- | 0.0001 | 0.4769 | - | |
| 310_VAL | MET |
8.3kJPN chr20:54945642 - |
- | 0.0001 | 0.9545 | - | |
| 343_ARG | GLN |
gnomAD chr20:54945542 rs200181472 |
- | 0.000170986 | 0.0975 | - | |
| 343_ARG | TRP |
8.3kJPN chr20:54945543 rs774552788 |
- | 0.0001 | 0.2283 | - | |
| 346_PHE | LEU |
ClinVar chr20:54945388 rs1455074519 |
Likely pathogenic | - | 0.9214 | Multiple myeloma [Human Phenotype Ontology:HP:0006775,MONDO:MONDO:0009693,MeSH:D009101,MedGen:C0026764,OMIM:254500,Orphanet:29073,Orphanet:85443] | |
| 373_MET | VAL |
VAR_041130
rs33923703 |
LB/B | - | 0.0673 | - | |
| 373_MET | VAL |
gnomAD chr20:54945309 rs33923703 |
- | 0.0187479 | 0.0673 | - | |
| 373_MET | VAL |
8.3kJPN chr20:54945309 rs33923703 |
- | 0.0001 | 0.0673 | - | |
| 386_ASN | HIS |
gnomAD chr20:54945270 rs763051712 |
- | 0.000131238 | 0.0476 | - |