PDB ID 1M4R     CHAIN A
Protein name Interleukin-22
Uniprot Accession Q9GZX6
The number of similar proteins 12
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1M4R (CHAIN: A)
1 Q9GZX6  
2 Q08AH7  
3 3Q1S   3Q1S  
4 Q9GZX6   Q9GZX6  
5 Q9GZX6   Q9GZX6   Q9GZX6  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   QGGAAAPISS   HCRLDKSNFQ   QPYITNRTFM   LAKEASLADN   NTDVRLIGEK   50
51   LFHGVSMSER   CYLMKQVLNF   TLEEVLFPQS   DRFQPYMQEV   VPFLARLSNR   100
101   LSTCHIEGDD   LHIQRNVQKL   KDTVKKLGES   GEIKAIGELD   LLFMSLRNAC   150
151   I           200

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
45_SER PRO gnomAD
chr12:68647096
rs202073032
- 0.000239067 0.2334 -
134_ILE VAL gnomAD
chr12:68645355
rs537609047
- 0.000470367 0.0806 -
143_ARG LYS 8.3kJPN
chr12:68645327
rs1565747878
- 0.0001 0.0681 -
158_SER GLY VAR_013078
rs2227507
LB/B - 0.0922 -
158_SER GLY gnomAD
chr12:68642647
rs2227507
- 0.00196212 0.0922 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.