PDB ID 1JV2     CHAIN A
Protein name INTEGRIN, ALPHA V
GenBank ID 14743192
The number of similar proteins 15
The number of binding states 4
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1JV2 (CHAIN: A)
1 P05106  
2 P02751   P05106  
3 P05106   6MSL  
4 P05106   4O02   4O02  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   FNLDVDSPAE   YSGPEGSYFG   FAVDFFVPSA   SSRMFLLVGA   PKANTTQPGI   50
51   VEGGQVLKCD   WSSTRRCQPI   EFDATGNRDY   AKDDPLEFKS   HQWFGASVRS   100
101   KQDKILACAP   LYHWRTEMKQ   EREPVGTCFL   QDGTKTVEYA   PCRSQDIDAD   150
151   GQGFCQGGFS   IDFTKADRVL   LGGPGSFYWQ   GQLISDQVAE   IVSKYDPNVY   200
201   SIKYNNQLAT   RTAQAIFDDS   YLGYSVAVGD   FNGDGIDDFV   SGVPRAARTL   250
251   GMVYIYDGKN   MSSLYNFTGE   QMAAYFGFSV   AATDINGDDY   ADVFIGAPLF   300
301   MDRGSDGKLQ   EVGQVSVSLQ   RASGDFQTTK   LNGFEVFARF   GSAIAPLGDL   350
351   DQDGFNDIAI   AAPYGGEDKK   GIVYIFNGRS   TGLNAVPSQI   LEGQWAARSM   400
401   PPSFGYSMKG   ATDIDKNGYP   DLIVGAFGVD   RAILYRARPV   ITVNAGLEVY   450
451   PSILNQDNKT   CSLPGTALKV   SCFNVRFCLK   ADGKGVLPRK   LNFQVELLLD   500
501   KLKQKGAIRR   ALFLYSRSPS   HSKNMTISRG   GLMQCEELIA   YLRDESEFRD   550
551   KLTPITIFME   YRLDYRTAAD   TTGLQPILNQ   FTPANISRQA   HILLDCGEDN   600
601   VCKPKLEVSV   DSDQKKIYIG   DDNPLTLIVK   AQNQGEGAYE   AELIVSIPLQ   650
651   ADFIGVVRNN   EALARLSCAF   KTENQTRQVV   CDLGNPMKAG   TQLLAGLRFS   700
701   VHQQSEMDTS   VKFDLQIQSS   NLFDKVSPVV   SHKVDLAVLA   AVEIRGVSSP   750
751   DHVFLPIPNW   EHKENPETEE   DVGPVVQHIY   ELRNNGPSSF   SKAMLHLQWP   800
801   YKYNNNTLLY   ILHYDIDGPM   NCTSDMEINP   LRIKISSLQT   TEKNDTVAGQ   850
851   GERDHLITKR   DLALSEGDIH   TLGCGVAQCL   KIVCQVGRLD   RGKSAILYVK   900
901   SLLWTETFMN   KENQNHSYSL   KSSASFNVIE   FPYKNLPIED   ITNSTLVTTN   950
951   VTWGIQP           1000

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
14_PRO ARG 8.3kJPN
chr2:187455196 		rs748486456
- 0.0002 -
26_PHE LEU gnomAD
chr2:187455233 		rs201076250
- 0.000193425 -
44_ASN THR 8.3kJPN
chr2:187466783 		-
- 0.0001 -
58_LYS ARG 8.3kJPN
chr2:187466825 		rs754337745
- 0.0001 -
60_ASP ALA 8.3kJPN
chr2:187466831 		-
- 0.0001 -
64_THR PRO gnomAD
chr2:187466842 		rs750649139
- 0.00326009 -
66_ARG GLN gnomAD
chr2:187466849 		rs201909609
- 0.000124443 -
66_ARG TRP 8.3kJPN
chr2:187466848 		rs200516634
- 0.0001 -
66_ARG GLN 8.3kJPN
chr2:187466849 		rs201909609
- 0.0004 -
77_ASN ASP 8.3kJPN
chr2:187487068 		rs1168435795
- 0.0001 -
79_ASP GLU gnomAD
chr2:187487076 		rs200368244
- 0.000123465 -
108_CYS TYR 8.3kJPN
chr2:187490204 		-
- 0.0001 -
113_HIS ARG 8.3kJPN
chr2:187490219 		rs1336656683
- 0.0001 -
192_VAL ILE 8.3kJPN
chr2:187500841 		rs200647242
- 0.0004 -
211_ARG GLN gnomAD
chr2:187500899 		rs376680231
- 0.000108022 -
211_ARG TRP 8.3kJPN
chr2:187500898 		rs372449821
- 0.0001 -
231_PHE ILE 8.3kJPN
chr2:187501815 		-
- 0.0001 -
232_ASN SER gnomAD
chr2:187501819 		rs184114187
- 0.000159086 -
250_LEU SER 8.3kJPN
chr2:187503040 		-
- 0.0001 -
255_ILE MET 8.3kJPN
chr2:187503144 		-
- 0.0001 -
328_THR MET 8.3kJPN
chr2:187506229 		rs375790223
- 0.0001 -
359_ALA VAL gnomAD
chr2:187511419 		rs145167954
- 0.000178155 -
373_VAL ILE gnomAD
chr2:187511460 		rs569411702
- 0.000196765 -
375_ILE VAL gnomAD
chr2:187511466 		rs3738918
- 0.0248177 -
375_ILE VAL 8.3kJPN
chr2:187511466 		rs3738918
- 0.0594 -
408_MET VAL 8.3kJPN
chr2:187511565 		-
- 0.0004 -
414_ILE THR 8.3kJPN
chr2:187511584 		rs757308379
- 0.0001 -
414_ILE MET 8.3kJPN
chr2:187511585 		-
- 0.0001 -
423_ILE THR 8.3kJPN
chr2:187514573 		-
- 0.0001 -
431_ARG LEU gnomAD
chr2:187514597 		rs750343053
- 0.000569832 -
441_ILE THR 8.3kJPN
chr2:187516723 		rs201241523
- 0.0002 -
444_ASN SER 8.3kJPN
chr2:187516732 		rs755750941
- 0.0002 -
452_SER GLY 8.3kJPN
chr2:187516755 		-
- 0.0004 -
453_ILE ASN 8.3kJPN
chr2:187516759 		-
- 0.0001 -
458_ASN SER gnomAD
chr2:187516774 		rs200705825
- 0.000115445 -
465_GLY ALA gnomAD
chr2:187516795 		rs147403786
- 0.000657533 -
465_GLY TER 8.3kJPN
chr2:187516794 		-
- 0.0001 -
506_GLY ARG 8.3kJPN
chr2:187521015 		-
- 0.0001 -
518_SER ALA gnomAD
chr2:187521051 		rs2230615
- 0.000203823 -
520_SER GLY 8.3kJPN
chr2:187521057 		rs200088164
- 0.0001 -
522_SER PHE gnomAD
chr2:187521064 		rs146565475
- 0.000100032 -
531_GLY VAL 8.3kJPN
chr2:187521091 		rs185792013
- 0.0001 -
540_ALA VAL gnomAD
chr2:187521118 		rs199670325
- 0.000190019 -
548_PHE LEU 8.3kJPN
chr2:187523779 		-
- 0.0001 -
577_ILE VAL 8.3kJPN
chr2:187523864 		-
- 0.0001 -
582_THR MET gnomAD
chr2:187523880 		rs150474737
- 0.000137055 -
613_ASP ASN 8.3kJPN
chr2:187529222 		-
- 0.0002 -
613_ASP GLU 8.3kJPN
chr2:187529224 		-
- 0.0002 -
619_ILE THR 8.3kJPN
chr2:187529241 		rs200809220
- 0.0001 -
622_ASP HIS 8.3kJPN
chr2:187529249 		-
- 0.0001 -
655_GLY ARG gnomAD
chr2:187529348 		rs200130364
- 0.000155161 -
677_ARG HIS 8.3kJPN
chr2:187529899 		rs554897868
- 0.0001 -
680_VAL ILE 8.3kJPN
chr2:187529907 		rs752134103
- 0.0005 -
721_ASN ILE 8.3kJPN
chr2:187531882 		rs772750590
- 0.0003 -
736_LEU PHE 8.3kJPN
chr2:187531926 		-
- 0.0001 -
753_VAL ILE gnomAD
chr2:187532417 		rs2230616
- 0.998257 -
766_PRO THR gnomAD
chr2:187532456 		rs201122594
- 0.000322319 -
772_VAL ILE 8.3kJPN
chr2:187532474 		rs193173970
- 0.0002 -
780_TYR CYS 8.3kJPN
chr2:187532499 		rs756998836
- 0.0001 -
785_ASN SER gnomAD
chr2:187533499 		rs61757099
- 0.000268264 -
800_PRO ARG 8.3kJPN
chr2:187533544 		rs767980859
- 0.0005 -
803_TYR CYS 8.3kJPN
chr2:187533553 		rs199789114
- 0.0001 -
877_ALA SER 8.3kJPN
chr2:187540343 		-
- 0.0001 -
894_SER ASN gnomAD
chr2:187540395 		rs56316527
- 0.00138018 -
899_VAL ILE gnomAD
chr2:187540409 		rs146319338
- 0.000111382 -
919_SER ALA 8.3kJPN
chr2:187540571 		rs202153093
- 0.0005 -
934_LYS ASN 8.3kJPN
chr2:187540618 		-
- 0.0005 -
945_THR ALA 8.3kJPN
chr2:187540649 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.