PDB ID 1IVO     CHAIN A
Protein name Epidermal Growth Factor Receptor
Uniprot Accession P00533
The number of similar proteins 23
The number of binding states 9
The number of binding partners 7

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1IVO (CHAIN: A)
1 P00533   P01133  
2 Monomeric state
3 3QWQ  
4 P01133  
5 E0ACT6  
6 4UV7   4UV7  
7 5XWD   5XWD  
8 1YY9   1YY9  
9 4KRO   4KRO   4KRO  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   LEEKKVCQGT   SNKLTQLGTF   EDHFLSLQRM   FNNCEVVLGN   LEITYVQRNY   50
51   DLSFLKTIQE   VAGYVLIALN   TVERIPLENL   QIIRGNMYYE   NSYALAVLSN   100
101   YDANKTGLKE   LPMRNLQEIL   HGAVRFSNNP   ALCNVESIQW   RDIVSSDFLS   150
151   NMSMDFQNHL   GSCQKCDPSC   PNGSCWGAGE   ENCQKLTKII   CAQQCSGRCR   200
201   GKSPSDCCHN   QCAAGCTGPR   ESDCLVCRKF   RDEATCKDTC   PPLMLYNPTT   250
251   YQMDVNPEGK   YSFGATCVKK   CPRNYVVTDH   GSCVRACGAD   SYEMEEDGVR   300
301   KCKKCEGPCR   KVCNGIGIGE   FKDSLSINAT   NIKHFKNCTS   ISGDLHILPV   350
351   AFRGDSFTHT   PPLDPQELDI   LKTVKEITGF   LLIQAWPENR   TDLHAFENLE   400
401   IIRGRTKQHG   QFSLAVVSLN   ITSLGLRSLK   EISDGDVIIS   GNKNLCYANT   450
451   INWKKLFGTS   GQKTKIISNR   GENSCKATGQ   VCHALCSPEG   CWGPEPRDCV   500
501   SCRNVSRGRE   CVDKCNLLEG   EPREFVENSE   CIQCHPECLP   QAMNITCTGR   550
551   GPDNCIQCAH   YIDGPHCVKT   CPAGVMGENN   TLVWKYADAG   HVCHLCHPNC   600
601   TYGCTGPGLE   GCPTNGPKIP   SI       650

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
11_SER ASN 8.3kJPN
chr7:55209994
rs1406387936
- 0.0001 0.1196 -
21_GLU LYS 8.3kJPN
chr7:55210023
-
- 0.0001 0.1494 -
28_GLN TER ClinVar
chr7:55210044
rs2128926255
Pathogenic - - EGFR-related lung cancer [MedGen:CN130014]
30_MET THR 8.3kJPN
chr7:55210051
-
- 0.0001 0.4051 -
47_GLN TER ClinVar
chr7:55210101
-
Pathogenic - - EGFR-related lung cancer [MedGen:CN130014]
74_ARG GLN VAR_019293
rs17289589
LB/B - 0.0707 -
74_ARG GLN gnomAD
chr7:55211050
rs17289589
- 0.000111338 0.0707 -
84_ARG LYS ClinVar
chr7:55211080
rs1057519828
Likely pathogenic - 0.909 Neoplasm of brain [Human Phenotype Ontology:HP:0030692,MONDO:MONDO:0021211,MeSH:D001932,MedGen:C0006118]
84_ARG GLY ClinVar
chr7:55211079
rs1057519888
Likely pathogenic - 0.9917 Glioblastoma|Neoplasm of brain|Brainstem glioma [MONDO:MONDO:0018177,MeSH:D005909,MedGen:C0017636,Orphanet:360|Human Phenotype Ontology:HP:0030692,MONDO:MONDO:0021211,MeSH:D001932,MedGen:C0006118|Human Phenotype Ontology:HP:0010796,MONDO:MONDO:0002911,MedGen:C0677865]
215_GLY ALA 8.3kJPN
chr7:55220326
rs1447176163
- 0.0002 0.8932 -
220_ARG TRP 8.3kJPN
chr7:55220340
rs554981236
- 0.0001 0.4378 -
223_ASP HIS 8.3kJPN
chr7:55220349
rs780001754
- 0.0002 0.8075 -
231_ARG TER ClinVar
chr7:55221719
rs776490661
Pathogenic - - EGFR-related lung cancer [MedGen:CN130014]
233_GLU LYS gnomAD
chr7:55221725
rs138847501
- 0.000115328 0.16 -
239_THR PRO ClinVar
chr7:55221743
rs1057519829
Likely pathogenic - 0.4747 Neoplasm of brain [Human Phenotype Ontology:HP:0030692,MONDO:MONDO:0021211,MeSH:D001932,MedGen:C0006118]
242_PRO ARG VAR_019294
rs17336639
LB/B - 0.2227 -
258_GLU LYS gnomAD
chr7:55221800
rs199796955
- 0.000322109 0.1005 -
258_GLU LYS 8.3kJPN
chr7:55221800
rs199796955
- 0.0001 0.1005 -
265_ALA VAL ClinVar
chr7:55221822
rs149840192
Likely pathogenic - 0.8289 Glioblastoma|Neoplasm of brain|Squamous cell carcinoma of the head and neck [MONDO:MONDO:0018177,MeSH:D005909,MedGen:C0017636,Orphanet:360|Human Phenotype Ontology:HP:0030692,MONDO:MONDO:0021211,MeSH:D001932,MedGen:C0006118|MONDO:MONDO:0010150,MeSH:D000077195,MedGen:C1168401,OMIM:275355,Orphanet:67037]
265_ALA ASP ClinVar
chr7:55221822
rs149840192
Likely pathogenic - 0.9515 Neoplasm of brain|Glioblastoma|Squamous cell carcinoma of the head and neck [Human Phenotype Ontology:HP:0030692,MONDO:MONDO:0021211,MeSH:D001932,MedGen:C0006118|MONDO:MONDO:0018177,MeSH:D005909,MedGen:C0017636,Orphanet:360|MONDO:MONDO:0010150,MeSH:D000077195,MedGen:C1168401,OMIM:275355,Orphanet:67037]
269_LYS TER ClinVar
chr7:55221833
rs2128935161
Pathogenic - - EGFR-related lung cancer [MedGen:CN130014]
302_CYS PHE ClinVar
chr7:55223610
rs886037891
Pathogenic - 0.9935 Cowden syndrome 1 [MONDO:MONDO:0008021,MedGen:CN072330,OMIM:158350]
404_GLY ASP VAR_072435
rs606231253
LP/P - 0.9982 Inflammatory skin and bowel disease, neonatal, 2 (NISBD2) [MIM:616069]
404_GLY ASP ClinVar
chr7:55225431
rs606231253
Pathogenic - 0.9982 Inflammatory skin and bowel disease, neonatal, 2|EGFR-related lung cancer [MONDO:MONDO:0014481,MedGen:C4015130,OMIM:616069,Orphanet:294023|MedGen:CN130014]
418_SER ASN 8.3kJPN
chr7:55227858
rs765091640
- 0.0014 0.092 -
443_LYS THR 8.3kJPN
chr7:55227933
-
- 0.0001 0.1271 -
457_PHE LEU 8.3kJPN
chr7:55227976
rs587778247
- 0.0001 0.9423 -
487_SER TYR gnomAD
chr7:55229225
rs371114444
- 0.000107418 0.5334 -
489_GLU TER ClinVar
chr7:55229230
rs754646330
Pathogenic - - EGFR-related lung cancer [MedGen:CN130014]
494_PRO LEU 8.3kJPN
chr7:55229246
rs564398642
- 0.0001 0.1467 -
497_ARG LYS VAR_019295
rs2227983
LB/B - 0.0606 -
497_ARG LYS gnomAD
chr7:55229255
rs2227983
- 0.292102 0.0606 -
497_ARG LYS 8.3kJPN
chr7:55229255
rs2227983
- 0.6191 0.0606 -
503_ARG GLN gnomAD
chr7:55229273
rs150477666
- 0.000131221 0.0621 -
504_ASN ASP 8.3kJPN
chr7:55229275
rs762336338
- 0.0001 0.1257 -
507_ARG TER ClinVar
chr7:55229284
rs1785707212
Pathogenic - - EGFR-related lung cancer [MedGen:CN130014]
511_CYS TER ClinVar
chr7:55229298
rs763346690
Pathogenic - - EGFR-related lung cancer [MedGen:CN130014]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.