PDB ID 1I3Q     CHAIN A
Protein name DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT
Uniprot Accession P04050
The number of similar proteins 132
The number of binding states 11
The number of binding partners 12

Molecule viewer


Only interaction residues
#binding
partners
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   MVGQQYSSAP   LRTVKEVQFG   LFSPEEVRAI   SVAKIRFPET   MDETQTRAKI   50
51   GGLNDPRLGS   IDRNLKCQTC   QEGMNECPGH   FGHIDLAKPV   FHVGFIAKIK   100
101   KVCECVCMHC   GKLLLDEHNE   LMRQALAIKD   SKKRFAAIWT   LCKTKMVCET   150
151   DVPSEDDPTQ   LVSRGGCGNT   QPTIRKDGLK   LVGSWKKDRA   TGDADEPELR   200
201   VLSTEEILNI   FKHISVKDFT   SLGFNEVFSR   PEWMILTCLP   VPPPPVRPSI   250
251   SFNESQRGED   DLTFKLADIL   KANISLETLE   HNGAPHHAIE   EAESLLQFHV   300
301   ATYMDNDIAG   QPQALQKSGR   PVKSIRARLK   GKEGRIRGNL   MGKRVDFSAR   350
351   TVISGDPNLE   LDQVGVPKSI   AKTLTYPEVV   TPYNIDRLTQ   LVRNGPNEHP   400
401   GAKYVIRDSG   DRIDLRYSKR   AGDIQLQYGW   KVERHIMDND   PVLFNRQPSL   450
451   HKMSMMAHRV   KVIPYSTFRL   NLSVTSPYNA   DFDGDEMNLH   VPQSEETRAE   500
501   LSQLCAVPLQ   IVSPQSNKPC   MGIVQDTLCG   IRKLTLRDTF   IELDQVLNML   550
551   YWVPDWDGVI   PTPAIIKPKP   LWSGKQILSV   AIPNGIHLQR   FDEGTTLLSP   600
601   KDNGMLIIDG   QIIFGVVEKK   TVGSSNGGLI   HVVTREKGPQ   VCAKLFGNIQ   650
651   KVVNFWLLHN   GFSTGIGDTI   ADGPTMREIT   ETIAEAKKKV   LDVTKEAQAN   700
701   LLTAKHGMTL   RESFEDNVVR   FLNEARDKAG   RLAEVNLKDL   NNVKQMVMAG   750
751   SKGSFINIAQ   MSACVGQQSV   EGKRIAFGFV   DRTLPHFSKD   DYSPESKGFV   800
801   ENSYLRGLTP   QEFFFHAMGG   REGLIDTAVK   TAETGYIQRR   LVKALEDIMV   850
851   HYDNTTRNSL   GNVIQFIYGE   DGMDAAHIEK   QSLDTIGGSD   AAFEKRYRVD   900
901   LLNTDHTLDP   SLLESGSEIL   GDLKLQVLLD   EEYKQLVKDR   KFLREVFVDG   950
951   EANWPLPVNI   RRIIQNAQQT   FHIDHTKPSD   LTIKDIVLGV   KDLQENLLVL   1000
1001   RGKNEIIQNA   QRDAVTLFCC   LLRSRLATRR   VLQEYRLTKQ   AFDWVLSNIE   1050
1051   AQFLRSVVHP   GEMVGVLAAQ   SIGEPATQMT   LNTFHFAGVA   SKKVTSGVPR   1100
1101   LKEILNVAKN   MKTPSLTVYL   EPGHAADQEQ   AKLIRSAIEH   TTLKSVTIAS   1150
1151   EIYYDPDPRS   TVIPEDEEII   QLHFSLLDEE   AEQSFDQQSP   WLLRLELDRA   1200
1201   AMNDKDLTMG   QVGERIKQTF   KNDLFVIWSE   DNDEKLIIRC   RVVRPKSLDA   1250
1251   ETEAEEDHML   KKIENTMLEN   ITLRGVENIE   RVVMMKYDRK   VPSPTGEYVK   1300
1301   EPEWVLETDG   VNLSEVMTVP   GIDPTRIYTN   SFIDIMEVLG   IEAGRAALYK   1350
1351   EVYNVIASDG   SYVNYRHMAL   LVDVMTTQGG   LTSVTRHGFN   RSNTGALMRC   1400
1401   SFEETVEILF   EAGASAELDD   CRGVSENVIL   GQMAPIGTGA   FDVMIDEESL   1450
1451   VKYMPEQKIT   EIEDGQDGGV   TPYSNESGLV   NADLDVKDEL   MFSPLVDSGS   1500
1501   NDAMAGGFTA   YGGADYGEAT   SPFGAYGEAP   TSPGFGVSSP   GFSPTSPTYS   1550
1551   PTSPAYSPTS   PSYSPTSPSY   SPTSPSYSPT   SPSYSPTSPS   YSPTSPSYSP   1600
1601   TSPSYSPTSP   SYSPTSPSYS   PTSPSYSPTS   PSYSPTSPSY   SPTSPSYSPT   1650
1651   SPSYSPTSPA   YSPTSPSYSP   TSPSYSPTSP   SYSPTSPSYS   PTSPNYSPTS   1700
1701   PSYSPTSPGY   SPGSPAYSPK   QDEQKHNENE   NSR     1750

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.