PDB ID 1HYR     CHAIN A
Protein name NKG2-D TYPE II INTEGRAL MEMBRANE PROTEIN
Uniprot Accession P26718
The number of similar proteins 37
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1HYR (CHAIN: A)
1 P26718   Q9TQ92  
2 Monomeric state
3 P26718  
4 P26718   Q5VY80  
5 P26718   Q8QN43  

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Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   NSLFNQEVQI   PLTESYCGPC   PKNWICYKNN   CYQFFDESKN   WYESQASCMS   50
51   QNASLLKVYS   KEDQDLLKLV   KSYHWMGLVH   IPTNGSWQWE   DGSILSPNLL   100
101   TIIEMQKGDC   ALYASSFKGY   IENCSTPNTY   ICMQRTV     150

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
93_GLU LYS 8.3kJPN
chr12:10532046
rs774643686
- 0.0001 0.0973 -
95_TYR ASP 8.3kJPN
chr12:10531299
-
- 0.0001 0.1816 -
123_SER ASN 8.3kJPN
chr12:10531214
rs1408677482
- 0.0002 0.9033 -
125_ALA SER gnomAD
chr12:10531209
rs147568901
- 0.000643532 0.1118 -
125_ALA ASP 8.3kJPN
chr12:10531208
-
- 0.0001 0.2062 -
177_ASN SER VAR_030738
rs2306182
LB/B - 0.0748 -
177_ASN SER gnomAD
chr12:10530734
rs2306182
- 0.000139326 0.0748 -
177_ASN SER 8.3kJPN
chr12:10530734
rs2306182
- 0.0183 0.0748 -
180_THR ALA 8.3kJPN
chr12:10525826
-
- 0.0006 0.1232 -
205_THR ALA 8.3kJPN
chr12:10525751
-
- 0.0001 0.0955 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.