PiSITE

PDB ID	1GFW	CHAIN	A
Protein name	CASPASE-3 (APOPAIN, P20)
Uniprot Accession	P42574
The number of similar proteins	96
The number of binding states	4
The number of binding partners	4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	1GFW (CHAIN: A)
1	P42574
2	P42574 2XZT
3	P42574 P42574 P42574
4	P42574 P42574 P42574 P98170

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Only interaction residues

#binding
partners

	3
	2
	1
	0

Sequence information

1

SGISLDNSYK

MDYPEMGLCI

IINNKNFHKS

TGMTSRSGTD

VDAANLRETF

50

51

RNLKYEVRNK

NDLTREEIVE

LMRDVSKEDH

SKRSSFVCVL

LSHGEEGIIF

100

101

GTNGPVDLKK

ITNFFRGDRC

RSLTGKPKLF

IIQACRGTEL

DCGIETD

150

Variants

	Residue	AA	Source / dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	AlphaMissense pathogenicity	Disease name
	38_LYS	ARG	8.3kJPN chr4:185556513 -	-	0.0001	0.069	-
	101_ARG	HIS	gnomAD chr4:185553427 rs146285839	-	0.000219689	0.0999	-
	101_ARG	CYS	8.3kJPN chr4:185553428 rs567223280	-	0.0001	0.1651	-
	105_LYS	GLU	8.3kJPN chr4:185553089 rs1280426773	-	0.0002	0.1024	-
	108_HIS	GLN	8.3kJPN chr4:185553078 -	-	0.0001	0.9814	-
	135_ASP	HIS	8.3kJPN chr4:185552999 -	-	0.0001	0.424	-
	164_ARG	CYS	8.3kJPN chr4:185552305 rs770145611	-	0.0001	0.9258	-

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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364