| PDB ID | 1F42
|
CHAIN | A |
|---|---|---|---|
| Protein name | INTERLEUKIN-12 BETA CHAIN | ||
| Uniprot Accession | P29460 | ||
| The number of similar proteins | 17 | ||
| The number of binding states | 10 | ||
| The number of binding partners | 8 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1F42 (CHAIN: A) | |
| 1 | Monomeric state |
| 2 |
Q9NPF7
|
| 3 |
P29459
|
| 4 |
Q9NPF7
3QWR
|
| 5 |
Q9NPF7
Q9NPF7
|
| 6 |
P42701
Q5VWK5
Q9NPF7
|
| 7 |
Q5VWK5
Q9NPF7
5MZV
|
| 8 |
Q9NPF7
5NJD
5NJD
|
| 9 |
3HMX
3HMX
P29459
|
| 10 |
Q9NPF7
4GRW
4GRW
4GRW
|
Downdload
Molecule viewer
|
Only interaction residues |
|
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|
Sequence information
|
Variants
| Residue | AA | Source | dbSNP | Clinical Significance |
Allele Frequency (> 0.0001) |
Disease name | |
|---|---|---|---|---|---|---|---|
| 11_VAL | ILE | VAR_020001 |
rs3213096
|
LB/B | - | - | |
| 11_VAL | ILE |
gnomAD chr5:158750329 |
rs3213096
|
- | 0.00633204 | - | |
| 11_VAL | ILE |
8.3kJPN chr5:158750329 |
rs3213096
|
- | 0.0001 | - | |
| 42_GLN | HIS |
8.3kJPN chr5:158750234 |
-
|
- | 0.0001 | - | |
| 48_GLY | SER |
8.3kJPN chr5:158750218 |
rs201684769
|
- | 0.0001 | - | |
| 56_GLN | PRO |
8.3kJPN chr5:158750193 |
rs1361534479
|
- | 0.0001 | - | |
| 65_GLN | TER |
ClinVar chr5:158750167 |
rs1562113567
|
Pathogenic | - | Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency [MONDO:MONDO:0013954,MedGen:C4013948,OMIM:614890,Orphanet:319558] | |
| 72_GLY | SER |
8.3kJPN chr5:158750146 |
-
|
- | 0.0001 | - | |
| 73_GLU | LYS |
gnomAD chr5:158750143 |
rs56287471
|
- | 0.000377893 | - | |
| 78_SER | LEU |
gnomAD chr5:158750127 |
rs144694601
|
- | 0.000131274 | - | |
| 87_ASP | TYR |
8.3kJPN chr5:158750101 |
-
|
- | 0.0001 | - | |
| 93_ASP | ASN |
8.3kJPN chr5:158750083 |
-
|
- | 0.0002 | - | |
| 102_LYS | ARG |
8.3kJPN chr5:158749513 |
rs199703726
|
- | 0.0008 | - | |
| 133_SER | ASN |
8.3kJPN chr5:158749420 |
rs1409483647
|
- | 0.0001 | - | |
| 147_THR | MET |
gnomAD chr5:158747505 |
rs565345523
|
- | 0.000163266 | - | |
| 147_THR | LYS |
8.3kJPN chr5:158747505 |
-
|
- | 0.0001 | - | |
| 148_CYS | TER |
ClinVar chr5:158747501 |
rs771036480
|
Pathogenic | - | Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency [MONDO:MONDO:0013954,MedGen:C4013948,OMIM:614890,Orphanet:319558] | |
| 157_ARG | THR |
gnomAD chr5:158747475 |
rs375159171
|
- | 0.000127379 | - | |
| 160_GLY | ARG |
gnomAD chr5:158747467 |
rs10045130
|
- | 0.000362261 | - | |
| 191_ASP | ASN |
8.3kJPN chr5:158747374 |
-
|
- | 0.0001 | - | |
| 193_VAL | ILE |
8.3kJPN chr5:158747368 |
rs79446920
|
- | 0.0001 | - | |
| 204_SER | ASN |
gnomAD chr5:158747334 |
rs55661460
|
- | 0.00220801 | - | |
| 204_SER | ASN |
8.3kJPN chr5:158747334 |
rs55661460
|
- | 0.0367 | - | |
| 222_LYS | ARG |
8.3kJPN chr5:158745868 |
-
|
- | 0.0001 | - | |
| 228_ARG | GLN |
gnomAD chr5:158745850 |
rs74644143
|
- | 0.000461405 | - | |
| 253_VAL | ILE |
gnomAD chr5:158745776 |
rs189324104
|
- | 0.00023465 | - | |
| 255_VAL | PHE |
8.3kJPN chr5:158745770 |
-
|
- | 0.0001 | - | |
| 266_ARG | THR |
gnomAD chr5:158743817 |
rs370904274
|
- | 0.00110552 | - | |
| 269_THR | MET |
gnomAD chr5:158743808 |
rs367828574
|
- | 0.000149554 | - | |
| 276_VAL | PHE | VAR_049170 |
rs3213119
|
LB/B | - | - | |
| 276_VAL | PHE |
gnomAD chr5:158743788 |
rs3213119
|
- | 0.0207309 | - | |
| 278_CYS | TER |
ClinVar chr5:158743780 |
rs1290071275
|
Pathogenic | - | Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency [MONDO:MONDO:0013954,MedGen:C4013948,OMIM:614890,Orphanet:319558] | |
| 279_ARG | CYS |
8.3kJPN chr5:158743779 |
rs780789325
|
- | 0.0001 | - | |
| 291_ARG | HIS |
8.3kJPN chr5:158743742 |
rs377524637
|
- | 0.0001 | - | |
| 294_SER | GLY |
8.3kJPN chr5:158743734 |
-
|
- | 0.0002 | - | |
| 303_VAL | MET |
gnomAD chr5:158743707 |
rs56064925
|
- | 0.000104486 | - | |
| 305_CYS | TER |
8.3kJPN chr5:158743699 |
rs138991749
|
- | 0.0004 | - |