| PDB ID | 1EBA
|
CHAIN | A |
|---|---|---|---|
| Protein name | PROTEIN (ERYTHROPOIETIN RECEPTOR) | ||
| Uniprot Accession | P19235 | ||
| The number of similar proteins | 25 | ||
| The number of binding states | 9 | ||
| The number of binding partners | 6 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1EBA (CHAIN: A) | |
| 1 |
P19235
|
| 2 |
6MOE
|
| 3 |
6MOL
|
| 4 |
P01588
|
| 5 |
2JIX
2JIX
|
| 6 |
4Y5V
4Y5V
|
| 7 |
P19235
6MOH
|
| 8 |
P19235
P01588
|
| 9 |
P19235
4Y5X
Q5NV67
|
Downdload
Molecule viewer
|
Only interaction residues |
|
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|
Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 21_ARG | TRP |
8.3kJPN chr19:11493891 rs751506215 |
- | 0.0001 | 0.1198 | - | |
| 22_GLY | GLU |
gnomAD chr19:11493887 rs45516306 |
- | 0.00549587 | 0.0841 | - | |
| 41_GLU | LYS |
8.3kJPN chr19:11493831 - |
- | 0.0001 | 0.7392 | - | |
| 48_VAL | ALA |
8.3kJPN chr19:11493809 rs780617943 |
- | 0.0001 | 0.0738 | - | |
| 54_SER | THR |
gnomAD chr19:11493791 rs140267472 |
- | 0.00018756 | 0.0697 | - | |
| 58_GLN | TER |
ClinVar chr19:11493780 rs370865377 |
Likely pathogenic | - | - | not provided [MedGen:CN517202] | |
| 58_GLN | ARG |
8.3kJPN chr19:11493779 rs1218322679 |
- | 0.0001 | 0.0674 | - | |
| 68_ARG | PRO |
8.3kJPN chr19:11492758 - |
- | 0.0001 | 0.0725 | - | |
| 75_ALA | VAL |
gnomAD chr19:11492737 rs146235694 |
- | 0.000929413 | 0.0909 | - | |
| 99_ARG | SER |
8.3kJPN chr19:11492666 - |
- | 0.0001 | 0.188 | - | |
| 113_ILE | VAL |
8.3kJPN chr19:11492624 - |
- | 0.0001 | 0.2476 | - | |
| 125_VAL | MET |
8.3kJPN chr19:11492508 rs1206410452 |
- | 0.0001 | 0.1029 | - | |
| 129_ALA | VAL |
8.3kJPN chr19:11492495 rs758156767 |
- | 0.0001 | 0.1636 | - | |
| 132_ALA | VAL |
8.3kJPN chr19:11492486 - |
- | 0.0002 | 0.1241 | - | |
| 138_VAL | ILE |
8.3kJPN chr19:11492469 - |
- | 0.0001 | 0.1055 | - | |
| 158_VAL | LEU |
8.3kJPN chr19:11492409 rs1326443454 |
- | 0.0001 | 0.4489 | - | |
| 160_VAL | ILE |
8.3kJPN chr19:11492403 - |
- | 0.0001 | 0.0751 | - | |
| 175_LEU | PRO |
gnomAD chr19:11491875 rs750657898 |
- | 0.00020678 | 0.0779 | - | |
| 179_THR | ALA |
8.3kJPN chr19:11491864 - |
- | 0.0001 | 0.3256 | - | |
| 180_GLU | ASP |
8.3kJPN chr19:11491859 - |
- | 0.0001 | 0.255 | - | |
| 188_GLY | CYS |
8.3kJPN chr19:11491837 rs185740642 |
- | 0.0069 | 0.4019 | - | |
| 201_ALA | VAL |
8.3kJPN chr19:11491797 - |
- | 0.0001 | 0.1645 | - | |
| 209_TRP | GLY |
gnomAD chr19:11491774 rs773564773 |
- | 0.00016984 | 0.9062 | - | |
| 215_PRO | THR |
8.3kJPN chr19:11491756 rs765522005 |
- | 0.0021 | 0.1004 | - |