PDB ID 1CXP     CHAIN A
Protein name MYELOPEROXIDASE
Uniprot Accession P05164
The number of similar proteins 43
The number of binding states 4
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1CXP (CHAIN: A)
1 P05164   P05164   P05164  
2 P05164  
3 P05164   P00450  
4 P05164   A0A0D1H8K9  

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Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   CPEQDKYRTI   TGMCNNRRSP   TLGASNRAFV   RWLPAEYEDG   FSLPYGWTPG   50
51   VKRNGFPVAL   ARAVSNEIVR   FPTDQLTPDQ   ERSLMFMQWG   QLLDHDLDFT   100
101   PEPA           150

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
7_TYR CYS VAR_015377 rs78950939
LP/P - Myeloperoxidase deficiency (MPOD) [MIM:254600]
7_TYR CYS ClinVar
chr17:56356914 		rs78950939
Likely pathogenic - Myeloperoxidase deficiency|not provided [MONDO:MONDO:0009694,MedGen:C0398595,OMIM:254600,Orphanet:2587|MedGen:C3661900]
7_TYR CYS gnomAD
chr17:56356914 		rs78950939
- 0.000458423 -
35_ALA PRO 8.3kJPN
chr17:56356735 		-
- 0.0001 -
36_GLU TER ClinVar
chr17:56356732 		rs778013714
Likely pathogenic - not provided|Myeloperoxidase deficiency [MedGen:C3661900|MONDO:MONDO:0009694,MedGen:C0398595,OMIM:254600,Orphanet:2587]; Alzheimer disease type 1|Myeloperoxidase deficiency [MONDO:MONDO:0007088,MedGen:C1863052,OMIM:104300|MONDO:MONDO:0009694,MedGen:C0398595,OMIM:254600,Orphanet:2587]
45_TYR HIS gnomAD
chr17:56356705 		rs202217586
- 0.000109161 -
75_GLN TER ClinVar
chr17:56356533 		rs754632893
Pathogenic/Likely pathogenic - Myeloperoxidase deficiency|MPO-related condition [MONDO:MONDO:0009694,MedGen:C0398595,OMIM:254600,Orphanet:2587|]
82_ARG LEU 8.3kJPN
chr17:56356511 		rs757797973
- 0.0001 -
85_MET THR VAR_015378 rs56378716
LP/P - Myeloperoxidase deficiency (MPOD) [MIM:254600]
85_MET THR gnomAD
chr17:56356502 		rs56378716
- 0.0102374 -
87_MET ARG 8.3kJPN
chr17:56356496 		rs200819121
- 0.0001 -
95_HIS GLN 8.3kJPN
chr17:56356471 		rs749102851
- 0.0002 -
104_ALA THR 8.3kJPN
chr17:56356446 		rs1411421218
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.