PDB ID 1CSG     CHAIN A
Protein name Granulocyte-macrophage colony-stimulating factor
Uniprot Accession P04141
The number of similar proteins 11
The number of binding states 5
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1CSG (CHAIN: A)
1 P04141  
2 Monomeric state
3 P15509  
4 P15509   P32927  
5 5C7X   5C7X  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   APARSPSPST   QPWEHVNAIQ   EARRLLNLSR   DTAAEMNETV   EVISEMFDLQ   50
51   EPTCLQTRLE   LYKQGLRGSL   TKLKGPLTMM   ASHYKQHCPP   TPETSCATQI   100
101   ITFESFKENL   KDFLLVIPFD   CWEPVQE       150

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
20_GLN HIS 8.3kJPN
chr5:131409627
-
- 0.0001 0.2587 -
23_ARG TRP 8.3kJPN
chr5:131409634
rs1224453147
- 0.0003 0.115 -
24_ARG HIS gnomAD
chr5:131409638
rs200145269
- 0.000111542 0.0765 -
24_ARG HIS 8.3kJPN
chr5:131409638
rs200145269
- 0.0001 0.0765 -
78_THR ILE 8.3kJPN
chr5:131410585
-
- 0.0001 0.2854 -
87_HIS GLN 8.3kJPN
chr5:131410613
-
- 0.0001 0.2803 -
98_THR ILE VAR_013089
rs2069640
LB/B - 0.1794 -
98_THR ILE gnomAD
chr5:131411454
rs2069640
- 0.00128431 0.1794 -
100_ILE THR VAR_001975
rs25882
LB/B - 0.1155 -
100_ILE THR gnomAD
chr5:131411460
rs25882
- 0.26468 0.1155 -
100_ILE THR 8.3kJPN
chr5:131411460
rs25882
- 0.5916 0.1155 -
101_ILE THR 8.3kJPN
chr5:131411463
-
- 0.0002 0.1933 -
102_THR ASN 8.3kJPN
chr5:131411466
rs755412035
- 0.0001 0.15 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.