PDB ID 1CMF     CHAIN A
Protein name CALMODULIN (VERTEBRATE)
Uniprot Accession P62157
The number of similar proteins 18
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1CMF (CHAIN: A)
1 Monomeric state
2 P15318  
3 P48539  
4 P19334  
5 Q99LM3  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   MKDTDSEEEI   REAFRVFDKD   GNGYISAAEL   RHVMTNLGEK   LTDEEVDEMI   50
51   READIDGDGQ   VNYEEFVQMM   TAK       100

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
89_PHE LEU ClinVar
chr14:90870295 		rs730882253
Likely pathogenic - Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]
89_PHE LEU ClinVar
chr2:47389442 		-
Likely pathogenic - Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
90_ARG HIS 8.3kJPN
chr10:5567320 		rs776439000
- 0.0019 -
93_ASP ALA ClinVar
chr19:47111841 		rs1060502608
Pathogenic - Long QT syndrome 1|not provided [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768|MedGen:C3661900]
95_ASP VAL ClinVar
chr2:47388996 		rs730882254
Pathogenic - Long QT syndrome 15|not provided|Long QT syndrome 1 [MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768|MedGen:C3661900|MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
95_ASP HIS ClinVar
chr19:47112103 		rs1060502607
Pathogenic - Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
95_ASP TYR ClinVar
chr2:47388997 		rs1573214371
Pathogenic - Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
95_ASP TYR ClinVar
chr14:90870723 		-
Pathogenic - Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]; Catecholaminergic polymorphic ventricular tachycardia 4 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286]
96_GLY SER 8.3kJPN
chr10:5567337 		rs190000968
- 0.0002 -
97_ASN SER ClinVar
chr14:90870730 		rs267607277
Pathogenic/Likely pathogenic - Catecholaminergic polymorphic ventricular tachycardia 4|Catecholaminergic polymorphic ventricular tachycardia 1|Long QT syndrome 14 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286|MONDO:MONDO:0011484,MedGen:C1631597,OMIM:604772,Orphanet:3286|MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]; Catecholaminergic polymorphic ventricular tachycardia 4|Catecholaminergic polymorphic ventricular tachycardia|Cardiovascular phenotype [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286|MONDO:MONDO:0017990,MedGen:C5574922,OMIM:PS604772,Orphanet:3286|MedGen:CN230736]
97_ASN SER ClinVar
chr2:47388990 		rs398124647
Pathogenic - Long QT syndrome 1|Long QT syndrome 15|Long QT syndrome [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768|MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768|MONDO:MONDO:0002442,MeSH:D008133,MedGen:C0023976]
97_ASN ILE ClinVar
chr2:47388990 		rs398124647
Pathogenic - Long QT syndrome 1|Long QT syndrome 15 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768|MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768]
104_GLU LYS ClinVar
chr14:90870750 		rs1057523130
Likely pathogenic - not provided [MedGen:CN517202]
104_GLU GLN ClinVar
chr2:47388970 		-
Likely pathogenic - Long QT syndrome 15 [MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768]
113_GLY ARG ClinVar
chr2:47388943 		rs2103823712
Pathogenic - SUDDEN INFANT DEATH SYNDROME [EFO:EFO_0005303,MeSH:D013398,MedGen:C0038644,OMIM:272120]
120_GLU LYS 8.3kJPN
chr10:5567409 		-
- 0.0001 -
126_ARG TRP gnomAD
chr10:5567427 		rs754327442
- 0.000119868 -
128_ALA VAL 8.3kJPN
chr10:5567434 		rs752809700
- 0.0002 -
129_ASP GLY ClinVar
chr14:90870826 		rs730882252
Pathogenic/Likely pathogenic - Long QT syndrome 14|not provided [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768|MedGen:C3661900]
129_ASP GLY ClinVar
chr19:47112206 		rs1599759554
Pathogenic - Long QT syndrome 16 [MONDO:MONDO:0032915,MedGen:C5394068,OMIM:618782]
129_ASP GLY ClinVar
chr2:47388894 		rs1573214163
Likely pathogenic - Long QT syndrome 15|Long QT syndrome 1 [MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768|MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
129_ASP ASN ClinVar
chr2:47388895 		rs2103823638
Pathogenic - Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
129_ASP GLU ClinVar
chr19:47112207 		rs35617141
Pathogenic - Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
129_ASP ASN 8.3kJPN
chr10:5567436 		rs777995357
- 0.0002 -
129_ASP GLU 8.3kJPN
chr10:5567438 		rs751753306
- 0.0002 -
130_THR ARG 8.3kJPN
chr10:5567440 		-
- 0.0001 -
131_ASP GLU ClinVar
chr2:47388887 		rs398124648
Pathogenic - Long QT syndrome 15|Long QT syndrome 1 [MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768|MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
131_ASP GLY ClinVar
chr19:47112212 		rs1057523474
Likely pathogenic - not provided [MedGen:CN517202]
131_ASP GLU ClinVar
chr19:47112213 		rs1064796271
Pathogenic - not provided [MedGen:CN517202]
131_ASP ASN ClinVar
chr14:90870831 		rs1595102640
Pathogenic - Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]; Catecholaminergic polymorphic ventricular tachycardia 4 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286]
131_ASP VAL ClinVar
chr14:90870832 		rs1887113791
Pathogenic - Catecholaminergic polymorphic ventricular tachycardia 4 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286]; Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]
131_ASP GLY ClinVar
chr2:47388888 		rs1687164164
Pathogenic - Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
131_ASP GLY ClinVar
chr14:90870832 		rs1887113791
Pathogenic - Catecholaminergic polymorphic ventricular tachycardia 4 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286]; Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]
131_ASP TYR ClinVar
chr2:47388889 		rs2103823612
Pathogenic - Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
132_GLY GLU ClinVar
chr14:90870835 		rs1555366045
Likely pathogenic - Catecholaminergic polymorphic ventricular tachycardia 4 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286]; Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]
132_GLY SER ClinVar
chr2:47388886 		rs2103823599
Likely pathogenic - Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
133_ASP HIS ClinVar
chr2:47388883 		rs398124650
Pathogenic/Likely pathogenic - Long QT syndrome 1|Long QT syndrome 15 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768|MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768]
135_GLN PRO ClinVar
chr2:47388876 		rs398124649
Pathogenic/Likely pathogenic - Long QT syndrome 1|Long QT syndrome 15 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768|MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768]
137_ASN LYS ClinVar
chr2:47388869 		rs1553431702
Pathogenic - Long QT syndrome 15 [MONDO:MONDO:0014550,MedGen:C4015695,OMIM:616249,Orphanet:101016,Orphanet:768]
139_GLU VAL ClinVar
chr14:90870856 		rs1064793078
Likely pathogenic - not provided [MedGen:CN517202]
140_GLU GLY ClinVar
chr19:47112382 		rs1555814427
Likely pathogenic - Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
140_GLU LYS ClinVar
chr19:47112238 		rs1599759598
Pathogenic - Long QT syndrome 16|Long QT syndrome 1 [MONDO:MONDO:0032915,MedGen:C5394068,OMIM:618782|MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
140_GLU GLY ClinVar
chr14:90871033 		rs1887120112
Pathogenic - Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]
140_GLU VAL ClinVar
chr14:90871033 		rs1887120112
Pathogenic - Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]
140_GLU ASP ClinVar
chr2:47387942 		rs2103821507
Likely pathogenic - Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
141_PHE LEU ClinVar
chr14:90871037 		rs199744595
Pathogenic - Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]
141_PHE LEU ClinVar
chr14:90871035 		rs1085307479
Pathogenic - not provided|Long QT syndrome 14 [MedGen:C3661900|MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]; Catecholaminergic polymorphic ventricular tachycardia 4 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286]
141_PHE LEU ClinVar
chr14:90871037 		rs199744595
Pathogenic - Long QT syndrome 14 [MONDO:MONDO:0014548,MedGen:C4015671,OMIM:616247,Orphanet:101016,Orphanet:768]; Catecholaminergic polymorphic ventricular tachycardia 4 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286]
144_MET ARG ClinVar
chr2:47387931 		rs1558693760
Likely pathogenic - Long QT syndrome 1 [MONDO:MONDO:0100316,MedGen:C4551647,OMIM:192500,Orphanet:101016,Orphanet:768]
144_VAL MET gnomAD
chr10:5567481 		rs530831313
- 0.000136752 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.