PiSITE

PDB ID	1BQT	CHAIN	A
Protein name	INSULIN-LIKE GROWTH FACTOR-I
Uniprot Accession	P05019
The number of similar proteins	19
The number of binding states	6
The number of binding partners	5

Molecule viewer

Only interaction residues

#binding
partners

1

GPETLCGAEL

VDALQFVCGD

RGFYFNKPTG

YGSSSRRAPQ

TGIVDECCFR

50

51

SCDLRRLEMY

CAPLKPAKSA

100

INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5

Insulin receptor

Insulin-like growth factor 1 receptor

Neural/ectodermal development factor IMP-L2

	P08833	Insulin-like growth factor-binding protein 1
	P22692	Insulin-like growth factor-binding protein 4

Residue	AA	Source / dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	AlphaMissense pathogenicity	Disease name
19_GLY	GLU	8.3kJPN chr12:102869441 -	-	0.0001	0.6917	-
28_PRO	HIS	8.3kJPN chr12:102813462 -	-	0.0001	0.6115	-
47_CYS	TER	ClinVar chr12:102813404 rs3730193	Likely pathogenic	-	-	Growth delay due to insulin-like growth factor type 1 deficiency [MONDO:MONDO:0012110,MedGen:C1837475,OMIM:608747,Orphanet:73272]
50_ARG	TRP	VAR_075825 rs587779350	US	-	0.3289	-
63_PRO	THR	8.3kJPN chr12:102813358 -	-	0.0001	0.2532	-
67_ALA	THR	VAR_056113 rs17884626	LB/B	-	0.0681	-
67_ALA	THR	gnomAD chr12:102813346 rs17884626	-	0.00111564	0.0681	-
70_ALA	THR	gnomAD chr12:102813337 rs151098426	-	0.000677329	0.0858	-

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