PDB ID 1BQT     CHAIN A
Protein name INSULIN-LIKE GROWTH FACTOR-I
Uniprot Accession P05019
The number of similar proteins 19
The number of binding states 6
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1BQT (CHAIN: A)
1 Monomeric state
2 P24593  
3 P06213  
4 P08069  
5 Q09024  
6 P08833   P22692  

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Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   GPETLCGAEL   VDALQFVCGD   RGFYFNKPTG   YGSSSRRAPQ   TGIVDECCFR   50
51   SCDLRRLEMY   CAPLKPAKSA         100

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
19_GLY GLU 8.3kJPN
chr12:102869441 		-
- 0.0001 -
28_PRO HIS 8.3kJPN
chr12:102813462 		-
- 0.0001 -
47_CYS TER ClinVar
chr12:102813404 		rs3730193
Likely pathogenic - Growth delay due to insulin-like growth factor type 1 deficiency [MONDO:MONDO:0012110,MedGen:C1837475,OMIM:608747,Orphanet:73272]
50_ARG TRP VAR_075825 rs587779350
US - -
63_PRO THR 8.3kJPN
chr12:102813358 		-
- 0.0001 -
67_ALA THR VAR_056113 rs17884626
LB/B - -
67_ALA THR gnomAD
chr12:102813346 		rs17884626
- 0.00111564 -
70_ALA THR gnomAD
chr12:102813337 		rs151098426
- 0.000677329 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.