PDB ID 1BMF     CHAIN A
Protein name BOVINE MITOCHONDRIAL F1-ATPASE
Uniprot Accession P19483
The number of similar proteins 89
The number of binding states 6
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1BMF (CHAIN: A)
1 P05631   P00829   P00829  
2 Monomeric state
3 P35435   P10719  
4 P01096   P05631   P00829   P00829  
5 P05631   P00829   P00829   P13621  
6 P05631   P00829   P00829   P13620  

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Only interaction residues
#binding
partners
  2
  1
  0

Sequence information

1   QKTGTAEVSS   ILEERILGAD   TSVDLEETGR   VLSIGDGIAR   VHGLRNVQAE   50
51   EMVEFSSGLK   GMSLNLEPDN   VGVVVFGNDK   LIKEGDIVKR   TGAIVDVPVG   100
101   EELLGRVVDA   LGNAIDGKGP   IGSKARRRVG   LKAPGIIPRI   SVREPMQTGI   150
151   KAVDSLVPIG   RGQRELIIGD   RQTGKTSIAI   DTIINQKRFN   DGTDEKKKLY   200
201   CIYVAIGQKR   STVAQLVKRL   TDADAMKYTI   VVSATASDAA   PLQYLAPYSG   250
251   CSMGEYFRDN   GKHALIIYDD   LSKQAVAYRQ   MSLLLRRPPG   REAYPGDVFY   300
301   LHSRLLERAA   KMNDAFGGGS   LTALPVIETQ   AGDVSAYIPT   NVISITDGQI   350
351   FLETELFYKG   IRPAINVGLS   VSRVGSAAQT   RAMKQVAGTM   KLELAQYREV   400
401   AAFAQFGSDL   DAATQQLLSR   GVRLTELLKQ   GQYSPMAIEE   QVAVIYAGVR   450
451   GYLDKLEPSK   ITKFENAFLS   HVISQHQALL   GKIRTDGKIS   EESDAKLKEI   500
501   VTNFLAGFEA           550

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
87_ILE THR gnomAD
chr18:43669883 		rs563376014
- 0.000127521 -
96_ASP GLY gnomAD
chr18:43669856 		rs148515768
- 0.000469741 -
105_GLY ASP 8.3kJPN
chr18:43669829 		-
- 0.0001 -
106_ARG HIS 8.3kJPN
chr18:43669826 		rs751020903
- 0.0001 -
121_ILE VAL 8.3kJPN
chr18:43669692 		rs746703083
- 0.0001 -
125_THR MET 8.3kJPN
chr18:43669679 		rs144159915
- 0.0002 -
126_ARG HIS 8.3kJPN
chr18:43669676 		rs765711330
- 0.0001 -
131_LEU VAL gnomAD
chr18:43669662 		rs11541929
- 0.000111437 -
152_ALA ASP 8.3kJPN
chr18:43669598 		-
- 0.0001 -
152_ALA THR 8.3kJPN
chr18:43669599 		-
- 0.0001 -
159_ILE VAL 8.3kJPN
chr18:43669578 		rs377180451
- 0.0001 -
164_ARG HIS ClinVar
chr18:43669562 		rs1555695342
Pathogenic/Likely pathogenic - not provided|Lactic acidosis|Mitochondrial complex V (ATP synthase) deficiency, nuclear type 4A [MedGen:C3661900|Human Phenotype Ontology:HP:0003128,Human Phenotype Ontology:HP:0003255,Human Phenotype Ontology:HP:0005960,MONDO:MONDO:0006040,MedGen:C0001125|MONDO:MONDO:0957254,MedGen:C5830480,OMIM:620358]
180_ILE VAL gnomAD
chr18:43668207 		rs77958705
- 0.00786245 -
202_ILE THR 8.3kJPN
chr18:43668140 		-
- 0.0001 -
204_VAL ILE gnomAD
chr18:43668135 		rs370646735
- 0.000110344 -
233_SER LEU 8.3kJPN
chr18:43667431 		rs778135381
- 0.0002 -
238_ASP VAL 8.3kJPN
chr18:43667416 		-
- 0.0001 -
253_MET VAL 8.3kJPN
chr18:43667372 		-
- 0.0001 -
278_TYR CYS ClinVar
chr18:43667188 		rs587777788
Pathogenic - Combined oxidative phosphorylation deficiency 22 [MONDO:MONDO:0020727,MedGen:C4015062,OMIM:616045]
286_ARG CYS ClinVar
chr18:43667165 		rs587776960
Pathogenic - Mitochondrial complex V (ATP synthase) deficiency nuclear type 4 [MONDO:MONDO:0014091,MedGen:C3808899,OMIM:615228,Orphanet:254913]
331_ALA VAL 8.3kJPN
chr18:43667029 		-
- 0.0001 -
362_ARG CYS 8.3kJPN
chr18:43666424 		rs201477144
- 0.0006 -
375_GLY ARG ClinVar
chr18:43666385 		-
Pathogenic - Mitochondrial complex V (ATP synthase) deficiency, nuclear type 4A [MONDO:MONDO:0957254,MedGen:C5830480,OMIM:620358]
398_ARG CYS 8.3kJPN
chr18:43666187 		rs1248385107
- 0.0001 -
420_ARG HIS 8.3kJPN
chr18:43666120 		rs770585609
- 0.0001 -
422_VAL MET 8.3kJPN
chr18:43666115 		rs771547673
- 0.0005 -
481_GLY ASP gnomAD
chr18:43664479 		rs775805857
- 0.00028917 -
492_GLN ARG 8.3kJPN
chr18:43664306 		-
- 0.0001 -
498_LYS GLU 8.3kJPN
chr18:43664289 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.