PDB ID 1BET     CHAIN A
Protein name BETA-NERVE GROWTH FACTOR
Uniprot Accession P01139
The number of similar proteins 31
The number of binding states 11
The number of binding partners 8

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1BET (CHAIN: A)
1 Monomeric state
2 P01139  
3 P01139   Q9EPR5  
4 P01139   P01139  
5 P01138   P07174  
6 4EDW   4EDW  
7 P01138   P04629   P04629  
8 P01138   P04629   P04629  
9 P01138   5JZ7   5JZ7   5JZ7  
10 P01139   P00757   P00757   P00756   P00756  
11 P01138   4EDX   4EDX   4EDX   4EDX  

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Only interaction residues
#binding
partners
  7
  6
  5
  4
  3
  2
  1
  0

Sequence information

1   GEFSVCDSVS   VWVGDKTTAT   DIKGKEVTVL   AEVNINNSVF   RQYFFETKCR   50
51   ASNPVESGCR   GIDSKHWNSY   CTTTHTFVKA   LTTDEKQAAW   RFIRIDTACV   100
101   CVLSRKA           150

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
49_PHE LEU 8.3kJPN
chr1:115828909
rs139541754
- 0.0001 - -
50_LYS ARG 8.3kJPN
chr1:115828905
rs375808064
- 0.0001 - -
54_PHE VAL 8.3kJPN
chr1:115828894
-
- 0.0001 - -
64_VAL ILE gnomAD
chr1:115828864
rs141889164
- 0.000178931 - -
64_VAL ILE 8.3kJPN
chr1:115828864
rs141889164
- 0.0001 - -
66_SER ARG 8.3kJPN
chr1:115828856
rs779744960
- 0.0001 - -
100_ARG TRP ClinVar
chr1:115828756
rs11466112
Pathogenic - - Congenital sensory neuropathy with selective loss of small myelinated fibers [MONDO:MONDO:0012092,MedGen:C0020075,OMIM:608654,Orphanet:64752]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.