PiSITE

PDB ID	1BE3	CHAIN	A
Protein name	CYTOCHROME BC1 COMPLEX
Uniprot Accession	P31800
The number of similar proteins	36
The number of binding states	9
The number of binding partners	9

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	1BE3 (CHAIN: A)
1	P07552 P00130 P13272 P13271 P00125 P00157 P23004 P13272
2	P23004
3	P00130 P13272 P13272 P13271 P00125 P00157 P23004
4	P13272 P13271 P00125 P00157 P23004 P13272 P00129
5	P07552 P00130 P13272 P13271 P00125 P00157 P23004
6	P00130 P13272 P13271 P00125 P00157 P23004 P13272
7	P00130 P13272 P13271 P00125 P00157 P23004 P13272 P00129
8	P00130 P13272 P13272 P13271 P00125 P00157 P23004 P00129
9	P07552 P00130 P13272 P13271 P00125 P00157 P23004 P13272 P00129

Downdload

Molecule viewer

Only interaction residues

#binding
partners

	3
	2
	1
	0

Sequence information

TATYAQALQS

VPETQVSQLD

NGLRVASEQS

SQPTCTVGVW

IDAGSRYESE

KNNGAGYFVE

HLAFKGTKNR

PGNALEKEVE

SMGAHLNAYS

TREHTAYYIK

100

101

ALSKDLPKAV

ELLADIVQNC

SLEDSQIEKE

RDVILQELQE

NDTSMRDVVF

150

151

NYLHATAFQG

TPLAQSVEGP

SENVRKLSRA

DLTEYLSRHY

KAPRMVLAAA

200

201

GGLEHRQLLD

LAQKHFSGLS

GTYDEDAVPT

LSPCRFTGSQ

ICHREDGLPL

250

251

AHVAIAVEGP

GWAHPDNVAL

QVANAIIGHY

DCTYGGGAHL

SSPLASIAAT

300

301

NKLCQSFQTF

NICYADTGLL

GAHFVCDHMS

IDDMMFVLQG

QWMRLCTSAT

350

351

ESEVLRGKNL

LRNALVSHLD

GTTPVCEDIG

RSLLTYGRRI

PLAEWESRIA

400

401

EVDARVVREV

CSKYFYDQCP

AVAGFGPIEQ

LPDYNRIRSG

MFWLRF

450

Binding partner information

	P07552	Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
	P00130	Ubiquinol-cytochrome c reductase complex 7.2 kDa protein
	P13272	Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial precursor (EC 1.10.2.2) (Rieske iron-sulfur protein) (RISP) [Contains: Ubiquinol-cytochrome c reductase 8 kDa protein (Complex III subunit IX)]
	P13271	Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
	P00125	Cytochrome c1, heme protein, mitochondrial
	P00157	Cytochrome b
	P23004	Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial precursor
	P13272	Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial precursor (EC 1.10.2.2) (Rieske iron-sulfur protein) (RISP) [Contains: Ubiquinol-cytochrome c reductase 8 kDa protein (Complex III subunit IX)]

Binding partner information

	P00130	CYTOCHROME B-C1 COMPLEX SUBUNIT 9
	P13272	CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL
	P13272	CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL
	P13271	CYTOCHROME B-C1 COMPLEX SUBUNIT 8
	P00125	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL
	P00157	CYTOCHROME B
	P23004	CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL

Binding partner information

	P13272	Ubiquinol-cytochrome C reductase iron-sulfur subunit, mitochondrial
	P13271	Ubiquinol-cytochrome C reductase complex ubiquinone-binding protein QP-C
	P00125	Cytochrome c1, heme protein, mitochondrial
	P00157	Cytochrome b
	P23004	Ubiquinol-cytochrome C reductase complex core protein 2, mitochondrial
	P13272	Ubiquinol-cytochrome C reductase iron-sulfur subunit, mitochondrial
	P00129	Ubiquinol-cytochrome C reductase complex 14 kDa protein

Binding partner information

	P07552	Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
	P00130	Ubiquinol-cytochrome c reductase complex 7.2 kDa protein
	P13272	Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial
	P13271	Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
	P00125	Cytochrome c1, heme protein, mitochondrial
	P00157	Cytochrome b
	P23004	Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial

Binding partner information

	P00130	Cytochrome b-c1 complex subunit 9
	P13272	Cytochrome b-c1 complex subunit Rieske, mitochondrial
	P13271	Cytochrome b-c1 complex subunit 8
	P00125	Cytochrome c1, heme protein, mitochondrial
	P00157	Cytochrome b
	P23004	Cytochrome b-c1 complex subunit 2, mitochondrial
	P13272	Cytochrome b-c1 complex subunit Rieske, mitochondrial

Binding partner information

	P00130	Ubiquinol-cytochrome C reductase complex 7.2 kDa protein
	P13272	Ubiquinol-cytochrome C reductase iron-sulfur subunit, mitochondrial
	P13271	Ubiquinol-cytochrome C reductase complex ubiquinone-binding protein QP-C
	P00125	Cytochrome c1, heme protein, mitochondrial
	P00157	Cytochrome b
	P23004	Ubiquinol-cytochrome C reductase complex core protein 2, mitochondrial
	P13272	Ubiquinol-cytochrome C reductase iron-sulfur subunit, mitochondrial
	P00129	Ubiquinol-cytochrome C reductase complex 14 kDa protein

Binding partner information

	P00130	Cytochrome b-c1 complex subunit 9
	P13272	Cytochrome b-c1 complex subunit Rieske, mitochondrial
	P13272	Cytochrome b-c1 complex subunit Rieske, mitochondrial
	P13271	Cytochrome b-c1 complex subunit 8
	P00125	Cytochrome c1, heme protein, mitochondrial
	P00157	Cytochrome b
	P23004	Cytochrome b-c1 complex subunit 2, mitochondrial
	P00129	Cytochrome b-c1 complex subunit 7

Binding partner information

	P07552	CYTOCHROME BC1 COMPLEX
	P00130	CYTOCHROME BC1 COMPLEX
	P13272	CYTOCHROME BC1 COMPLEX
	P13271	CYTOCHROME BC1 COMPLEX
	P00125	CYTOCHROME BC1 COMPLEX
	P00157	CYTOCHROME BC1 COMPLEX
	P23004	CYTOCHROME BC1 COMPLEX
	P13272	CYTOCHROME BC1 COMPLEX
	P00129	CYTOCHROME BC1 COMPLEX

Variants

Residue	AA	Source / dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	AlphaMissense pathogenicity	Disease name
17_SER	GLY	gnomAD chr3:48646654 rs117171524	-	0.000754354	-	-
17_SER	GLY	8.3kJPN chr3:48646654 rs117171524	-	0.0001	-	-
20_ASP	GLU	8.3kJPN chr3:48646643 -	-	0.0001	-	-
55_ALA	SER	gnomAD chr3:48643235 rs201250580	-	0.000199149	-	-
86_LEU	PRO	ClinVar chr3:48642152 -	Likely pathogenic	-	-	Parkinsonism with polyneuropathy [MONDO:MONDO:0036193,MedGen:C5543299,OMIM:619279,Orphanet:611237]
181_ASP	HIS	gnomAD chr3:48641060 rs17080284	-	0.00222461	-	-
181_ASP	HIS	8.3kJPN chr3:48641060 rs17080284	-	0.0359	-	-
212_ALA	THR	gnomAD chr3:48638871 rs145767014	-	0.000119379	-	-
227_ALA	THR	8.3kJPN chr3:48638826 -	-	0.0001	-	-
232_THR	SER	8.3kJPN chr3:48638811 -	-	0.0001	-	-
233_PRO	ARG	gnomAD chr3:48638807 rs149245457	-	0.00313314	-	-
233_PRO	ARG	8.3kJPN chr3:48638807 rs149245457	-	0.0027	-	-
235_ARG	HIS	gnomAD chr3:48638801 rs62618742	-	0.0168131	-	-
235_ARG	CYS	gnomAD chr3:48638802 rs533718471	-	0.000131387	-	-
242_ARG	CYS	ClinVar chr3:48638548 rs201911056	Likely pathogenic	-	-	Hypertrophic cardiomyopathy [Human Phenotype Ontology:HP:0001639,MONDO:MONDO:0005045,MeSH:D002312,MedGen:C0007194,Orphanet:217569]
242_ARG	CYS	8.3kJPN chr3:48638548 rs201911056	-	0.0001	-	-
267_ASN	SER	gnomAD chr3:48638472 rs144710790	-	0.00233837	-	-
274_ASN	SER	gnomAD chr3:48638451 rs187641562	-	0.000319415	-	-
274_ASN	SER	8.3kJPN chr3:48638451 rs187641562	-	0.0003	-	-
277_ILE	LEU	ClinVar chr3:48638443 rs2107843274	Pathogenic	-	-	Parkinsonism with polyneuropathy [MONDO:MONDO:0036193,MedGen:C5543299,OMIM:619279,Orphanet:611237]
278_GLY	SER	gnomAD chr3:48638440 rs145869559	-	0.00045596	-	-
280_TYR	SER	ClinVar chr3:48638433 rs780978963	Pathogenic	-	-	Parkinsonism with polyneuropathy [MONDO:MONDO:0036193,MedGen:C5543299,OMIM:619279,Orphanet:611237]
281_ASP	GLY	8.3kJPN chr3:48638430 -	-	0.0001	-	-
304_CYS	TYR	8.3kJPN chr3:48638227 -	-	0.0001	-	-
316_GLU	VAL	8.3kJPN chr3:48638191 -	-	0.0001	-	-
340_GLY	ARG	8.3kJPN chr3:48638120 rs139928470	-	0.0001	-	-
356_ARG	GLN	gnomAD chr3:48637959 rs777309520	-	0.000111346	-	-
380_GLY	ARG	8.3kJPN chr3:48637558 -	-	0.0001	-	-
381_ARG	CYS	8.3kJPN chr3:48637555 rs370334893	-	0.0001	-	-
388_ARG	CYS	8.3kJPN chr3:48637534 rs780875481	-	0.0001	-	-
408_ARG	CYS	8.3kJPN chr3:48637122 rs762050976	-	0.0001	-	-
425_TYR	ASN	gnomAD chr3:48637071 rs202030377	-	0.000226902	-	-
440_GLY	SER	8.3kJPN chr3:48636584 rs1393314057	-	0.0001	-	-

(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364